Browse our anti-MAP3K5 (MAP3K5) Antibodies

Human Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. Knockdown of miR (show MLXIP Antibodies)-20a enhanced sensitivity of colorectal cancer cells to cisplatin through the ROS (show ROS1 Antibodies)/ASK1/JNK (show MAPK8 Antibodies) pathway.

2. Findings offer insight into positive regulation of Akt (show AKT1 Antibodies) signaling through P2Y12 (show P2RY12 Antibodies) phosphorylation as well as MAPK (show MAPK1 Antibodies) signaling in platelets by ASK1.

3. Cold stress-induced ferroptosis involves the ASK1-p38 (show CRK Antibodies) pathway.

4. TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1 (show PRMT1 Antibodies)

5. These findings indicate that chaetocin arrests the cell cycle and induces apoptosis by regulating the reactive oxygen species-mediated ASK-1/JNK (show MAPK8 Antibodies) signaling pathways.

6. Findings provide evidence that ASK-1 expression is regulated by SLC35F2 (show SLC35F2 Antibodies) which exerts its oncogenic effect on papillary thyroid carcinoma progression through activation of TGFBR-1 (show TGFBR1 Antibodies) and ASK-1.

7. Co-administration of acetaminophen and 5'-AMP (show APRT Antibodies) significantly ameliorated APAP-induced hepatotoxicity in mice. This was triggered by attenuating apoptosis signal-regulated kinase 1(ASK1) methylation and increasing ubiquitination-mediated ASK1 protein degradation.

8. The anti-cancer mechanism for the AgNPs may be involved in activating the ASK1-JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies)-Caspase-3 (show CASP3 Antibodies) pathway.

9. TRAF1 (show TRAF1 Antibodies) functions as a positive regulator of insulin (show INS Antibodies) resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1-P38 (show CRK Antibodies)/JNK (show MAPK8 Antibodies) axis.

10. LRRK2-induced apoptosis was suppressed by ASK1 inhibition in neuronal stem cells derived from patients with Parkinson's disease (PD). These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. PBL27 interacts with both CERK1 and the MAPK (show MAPK1 Antibodies) kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK (show MAPK1 Antibodies) kinase activation and disease resistance to Alternaria brassicicola.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. Findings offer insight into positive regulation of Akt (show AKT1 Antibodies) signaling through P2Y12 (show P2RY12 Antibodies) phosphorylation as well as MAPK (show MAPK1 Antibodies) signaling in platelets by ASK1.

2. This study demonstrated that the first evidence suggesting that ASK1 may play some role in the pathophysiology of Alzheimer's Disease and brain aging.

3. Oxidative and endoplasmic reticulum stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury.

4. The results of this investigation indicate ASK1 inhibition prolongs keratinocyte and blastemal cell activation leading to ear regeneration.

5. These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.

6. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

7. These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA (show F3 Antibodies)-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis.

8. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Antibodies)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Antibodies) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

9. ASK1 MAP kinase (show MAPK1 Antibodies) signaling cascade is an important regulator of chondrocyte terminal differentiation.

10. ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. PP2A (show PPP2R2B Antibodies) and AIP1 (show PDCD6IP Antibodies) cooperatively induce activation of ASK1-JNK (show MAPK8 Antibodies) signaling and vascular endothelial cell apoptosis.

2. These results indicate an important regulatory role of ASK1 in porcine circovirus type 2-induced apoptotic responses.

3. MAP3K5 is expressed in the heart, liver, spleen, lung, kidney, muscle, fat, pancrea, ileum, and stomach tissues of pigs.