Browse our anti-MAP3K5 (MAP3K5) Antibodies

Human Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. Findings provide evidence that ASK-1 expression is regulated by SLC35F2 (show SLC35F2 Antibodies) which exerts its oncogenic effect on papillary thyroid carcinoma progression through activation of TGFBR-1 (show TGFBR1 Antibodies) and ASK-1.

2. Co-administration of acetaminophen and 5'-AMP (show APRT Antibodies) significantly ameliorated APAP-induced hepatotoxicity in mice. This was triggered by attenuating apoptosis signal-regulated kinase 1(ASK1) methylation and increasing ubiquitination-mediated ASK1 protein degradation.

3. The anti-cancer mechanism for the AgNPs may be involved in activating the ASK1-JNK (show MAPK8 Antibodies)/p38 (show CRK Antibodies)-Caspase-3 (show CASP3 Antibodies) pathway.

4. TRAF1 (show TRAF1 Antibodies) functions as a positive regulator of insulin (show INS Antibodies) resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1-P38 (show CRK Antibodies)/JNK (show MAPK8 Antibodies) axis.

5. LRRK2-induced apoptosis was suppressed by ASK1 inhibition in neuronal stem cells derived from patients with Parkinson's disease (PD). These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD

6. Apoptosis signal-regulating kinase 1 (ASK1) expression was dramatically suppressed and correlated with hepatocyte nuclear factor 4alpha (HNF4alpha (show HNF4A Antibodies)) levels in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tissues.

7. ASK1 phosphorylated and stabilized TLX (show CD46 Antibodies), which led induction of HIF-1alpha (show HIF1A Antibodies), and its downstream VEGF-A (show VEGFA Antibodies) in an Akt (show AKT1 Antibodies) dependent manner.

8. CD40 (show CD40 Antibodies) activation resulted in down-regulation of Thioredoxin (Trx)-1 (show TXN Antibodies) to permit ASK1 activation and apoptosis. Although soluble receptor (show IFNAR1 Antibodies) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (show CD40 Antibodies) agonist and pharmacological inhibition of Trx-1 (show MLL Antibodies) was functionally equivalent to the signal triggered by mCD40L

9. These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.

10. from the two catalytic cysteines of TRX1 (show MLL Antibodies) the residue C32 (show CKLF Antibodies) is responsible for the high-affinity binding of TRX1 (show MLL Antibodies) to the ASK1-TRX (show VAC14 Antibodies)-binding domain in reducing conditions

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. PBL27 interacts with both CERK1 and the MAPK (show MAPK1 Antibodies) kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK (show MAPK1 Antibodies) kinase activation and disease resistance to Alternaria brassicicola.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. The results of this investigation indicate ASK1 inhibition prolongs keratinocyte and blastemal cell activation leading to ear regeneration.

2. These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.

3. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

4. These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA (show F3 Antibodies)-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis.

5. Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (show AKT1 Antibodies)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (show AKT1 Antibodies) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.

6. ASK1 MAP kinase (show MAPK1 Antibodies) signaling cascade is an important regulator of chondrocyte terminal differentiation.

7. ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.

8. ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta (show TGFB1 Antibodies).

9. ASK1 signalling regulates brown and beige (show LYST Antibodies) adipocyte function.

10. blocking MPTP (show PTPN2 Antibodies)-mediated TNF (show TNF Antibodies) signaling through intrathecal administration of TNF (show TNF Antibodies)-neutralizing antibody prevented Trx1 (show TXN Antibodies) oxidation and downstream ASK1-p38 MAPK (show MAPK14 Antibodies) activation

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) interaction partners

1. PP2A (show PPP2R2B Antibodies) and AIP1 (show PDCD6IP Antibodies) cooperatively induce activation of ASK1-JNK (show MAPK8 Antibodies) signaling and vascular endothelial cell apoptosis.

2. These results indicate an important regulatory role of ASK1 in porcine circovirus type 2-induced apoptotic responses.

3. MAP3K5 is expressed in the heart, liver, spleen, lung, kidney, muscle, fat, pancrea, ileum, and stomach tissues of pigs.