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anti-Human MAPK12 Antibodies:
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Cow (Bovine) Polyclonal MAPK12 Primary Antibody for WB - ABIN611036
Fulda, Meyer, Debatin: Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. in Oncogene 2002
Show all 3 Pubmed References
Human Polyclonal MAPK12 Primary Antibody for PLA, WB - ABIN520005
Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. in Molecular & cellular proteomics : MCP 2013
Study propose a model for sequential roles of MPK12, HT1, and GHR1 in the ABA-independent regulation of SLAC1 during CO2-induced stomatal closure.
MPK9 (show MAPK9 Antibodies) and MPK12 are positive regulators of salicylic acid signaling in Arabidopsis guard cells.
MPK9 (show MAPK9 Antibodies) and MPK12 are key regulators mediating both abscisic acid (ABA) and Methyl jasmonate (MeJA) signalling in guard cells.
MPK9 (show MAPK9 Antibodies) and MPK12 function redundantly downstream of extracellular reactive oxygen production and intracellular accumulation, cytosolic alkalisation and Ca(2 (show CA2 Antibodies)+)cytosolic oscillation in yeast elcictor-induced stomatal closure
MPK9 (show MAPK9 Antibodies) and MPK12 act downstream of ROS (show ROS1 Antibodies) and cytosolic Ca2 (show CA2 Antibodies)+ and upstream of anion channels in the guard cell abscisic acid signaling cascade.
MAP kinases MPK9 (show MAPK9 Antibodies) and MPK12 are preferentially expressed in guard cells and positively regulate ROS (show ROS1 Antibodies)-mediated ABA signaling.
MPK12 is both a physiological substrate of IBR5 and a novel negative regulator of auxin signaling.
There was significant association between p38gamma expression and esophageal squamous cell carcinoma clinical stage, lymph nodes metastases, and tumor volume. p38delta overexpression can promote tumorigenesis in nude mice model xenografted with Eca109 cells whose basal level of p38delta was stably over-expressed and p38gamma was stably knocked down.
This study reveals a novel pathway that directly links ErbB4 (show ERBB4 Antibodies) and p38gamma to the transcriptional machinery of NKx2.5 (show NKX2-5 Antibodies)-GATA4 (show GATA4 Antibodies) complex which is critical for cardiomyocyte formation during mammalian heart development.
during interphase ERK3 (show MAPK4 Antibodies) is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis
Taken together our data suggest that as cells initiate adhesion to matrix increasing levels of ERK3 (show MAPK4 Antibodies) at the cell periphery are required to orchestrate cell morphology changes which can then drive migratory behavior.
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD (show TSC2 Antibodies) therapy
analysis of how allosteric regulation of p38gamma and PTPN3 (show PTPN3 Antibodies) involves a PDZ domain (show INADL Antibodies)-modulated complex formation
Thus, in endothelial cells p38alpha (show MAPK14 Antibodies) mediates apoptotic signaling, whereas p38beta (show MAPK11 Antibodies) and p38gamma transduce survival signaling
p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
SEPW1 (show SEPW1 Antibodies) silencing increases MKK4 (show MAP2K4 Antibodies), which activates p38gamma, p38delta, and JNK2 (show MAPK9 Antibodies) to phosphorylate p53 (show TP53 Antibodies) on Ser (show SIGLEC1 Antibodies)-33 and cause a transient G(1) arrest.
phosphorylation at Ser (show SIGLEC1 Antibodies)-118 is required for ER to bind both p38gamma and c-Jun (show JUN Antibodies), thereby promoting ER relocation from ERE to AP-1 (show FOSB Antibodies) promoter sites.
p38gamma mitogen-activated protein kinase (show MAPK1 Antibodies) mediates inflammatory signaling to promote colon tumorigenesis
p38gamma and p38delta control heart growth by modulating mTOR (show FRAP1 Antibodies) pathway through DEPTOR (show DEPTOR Antibodies) phosphorylation and subsequent degradation.
Findings provide genetic evidence that p38gamma and p38delta have essential roles in skin tumour development.
Together, our results establish that p38gamma and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma and p38kappa as potential targets for cancer therapy.
An energetic signal may trigger phosphorylation of the p38-gamma isoform which may explain how contractions differentially activate signaling pathways.
p38gamma and p38delta are crucial regulators of inflammatory joint destruction in collagen-induced arthritis.
p38gamma and p38delta kinases regulate the Toll-like receptor 4 (TLR4 (show TLR4 Antibodies))-induced cytokine production by controlling ERK1/2 protein kinase (show CDK7 Antibodies) pathway activation
results indicate that p38gamma and p38delta have a role in the suppression of tumor development
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
mitogen-activated protein kinase 12
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, stress-activated protein kinase 3
, MAP kinase p38 gamma
, mitogen-activated protein kinase 3
, mitogen-activated protein kinase p38 gamma
, mitogen activated protein kinase 12
, stress activated protein kinase 3
, SAP kinase-3