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anti-Human MAPK3 Antibodies:
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Human Polyclonal MAPK3 Primary Antibody for WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
Show all 6 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
Show all 6 Pubmed References
Chicken Polyclonal MAPK3 Primary Antibody for ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
Show all 9 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody for IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
Show all 4 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
Show all 3 Pubmed References
Human Polyclonal MAPK3 Primary Antibody for WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
Show all 3 Pubmed References
Mouse (Murine) Polyclonal MAPK3 Primary Antibody for IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
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Human Polyclonal MAPK3 Primary Antibody for IHC (p) - ABIN2473492
: [Aleksandr Semenovich Iontov (on his 70th birthday)]. in Arkhiv anatomii, gistologii i émbriologii 1978
Show all 2 Pubmed References
Human Monoclonal MAPK3 Primary Antibody for ICC, FACS - ABIN969277
Karreth, DeNicola, Winter, Tuveson: C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). in Molecular cell 2009
Human Polyclonal MAPK3 Primary Antibody for ELISA, WB - ABIN2473489
Nishimoto, Nishida: MAPK signalling: ERK5 versus ERK1/2. in EMBO reports 2006
Show all 2 Pubmed References
RASSF7 promotes cell proliferation through activating MEK1 (show MAP2K1 Antibodies)/MEK2 (show MAP2K2 Antibodies)-ERK1/ERK2 (show MAPK1 Antibodies) signaling pathway in hepatocellular carcinoma.
SHP-2 (show PTPN11 Antibodies) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (show IL17C Antibodies) signaling.
intact keratin filaments are regulators for PKB/Akt (show AKT1 Antibodies) and p44 (show GTF2H2 Antibodies)/42 activity, basal and in response to stretch.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (show CRK Antibodies)/TRAF-6 (show TRAF6 Antibodies)/ERK (show EPHB2 Antibodies) MAP kinases pathways has been reported.
Integrated ERK1/ERK2 (show MAPK1 Antibodies) response to B (show TDO2 Antibodies)-cell receptor stimulation and SF3B1 (show SF3B2 Antibodies) gene mutations refine prognosis in chronic lymphocytic leukemia.
These findings identified the relationship between ERK1/2 Snitrosylation and phosphorylation.
A cellular threshold for active ERK1/2 levels determines Raf (show RAF1 Antibodies)/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies)-mediated growth arrest versus death responses.
ERK1/2/p53 (show TP53 Antibodies)/PUMA (show BBC3 Antibodies) signaling axis is related to cisplatin-induced cell death in ovarian cancer cells.
results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha (show PPARA Antibodies) signaling, inhibiting the TLR4 (show TLR4 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (show TLR4 Antibodies)/ERK1/2/AP-1 (show FOSB Antibodies)/STAT3 (show STAT3 Antibodies)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 pathways is to regulate capacitation and acrosome reaction.
Low ERK1 Phosphorylation is associated with low liver regeneration.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
In a retinitis pigmentosa mouse model, TrkC (show NTRK3 Antibodies) activity generates phosphorylated Erk (show EPHB2 Antibodies), which upregulates glial TNF-alpha (show TNF Antibodies), causing selective neuronal death.
A. fumigatus increased PAR-2 expression and elevated disease, PMN infiltration, and proinflammatory cytokine expreERK1 Kinasession through PAR-2, which may be modified by p-ERK1/2.
ERK1 and ERK2 (show MAPK1 Antibodies) play specific roles in beta cells. ERK2 (show MAPK1 Antibodies) cannot always compensate for the lack of ERK1 but the absence of a clear-cut phenotype in Erk1 (-/-) mice shows that ERK1 is dispensable in normal conditions.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (show CRK Antibodies) Pathways and the Interaction with Cell-Surface-HSP70 (show HSP70 Antibodies).
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
ERK1 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (show CRK Antibodies) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (show MAPK8 Antibodies) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
Taken together, the results of our present study indicated that DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. And it may provide a new therapeutic option for MM patients.
MAPK3 role in the oocyte maturation
ERK1/2-Akt1 (show AKT1 Antibodies) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (show SH3GL1 Antibodies) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (show MAPK1 Antibodies) pathway
ERK1 and ERK2 (show MAPK1 Antibodies) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (show HSPA1A Antibodies) in response to heat stress is dependent on ERK (show MAPK1 Antibodies) activation in Pac2 (show PSMG2 Antibodies) cells.
Data define distinct roles for ERK1 and ERK2 (show MAPK1 Antibodies) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (show EGFR Antibodies) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (show THBS1 Antibodies), fibronectin (show FN1 Antibodies), and vitronectin (show VTN Antibodies) are differentially dependent upon RAS, ERK1/2, and p38 (show MAPK14 Antibodies) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Antibodies) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (show MAPK1 Antibodies).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (show BCL2L11 Antibodies).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (show CSF2 Antibodies) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (show MAPK1 Antibodies)-dependent MTOR (show FRAP1 Antibodies) signal transduction cascades.
PGRN (show GRN Antibodies) inhibits adipogenesis in porcine preadipocytes partially through ERK (show MAPK1 Antibodies) activation mediated PPARgamma (show PPARG Antibodies) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Antibodies)/ERK (show MAPK1 Antibodies)/TSC2 (show TSC2 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (show MAPK8 Antibodies)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (show MAPK14 Antibodies) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (show IGF1 Antibodies) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (show IGF1R Antibodies)
The results suggest that the MPK-1 (show MAPK1 Antibodies)/ERK (show MAPK1 Antibodies) regulatory network, including FBF-1 (show FBF1 Antibodies), FBF-2, and LIP-1 (show CENPJ Antibodies), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (show FGFR3 Antibodies) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (show SUV420H1 Antibodies) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (show MAPK1 Antibodies) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (show CDC42 Antibodies) GTPase (show RACGAP1 Antibodies).
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6 (show MAPK6 Antibodies), in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (show SPINT1 Antibodies), HAI2 (show SPINT2 Antibodies), and HAI3 through ABF/AREB transcription factors
Constitutive active-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (show MAPK4 Antibodies), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 (show MAPK6 Antibodies) phosphorylate and destabilize ICE1, which negatively regulates CBF (show CEBPZ Antibodies) expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (show MAPK6 Antibodies) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (show MAPK6 Antibodies) can both interact with SPOROCYTELESS/NOZZLE (SPL (show SGPL1 Antibodies)) in vitro and in vivo and can phosphorylate the SPL (show SGPL1 Antibodies) protein in vitro.
MKK4 (show MAP2K4 Antibodies), MKK5 (show MAP2K5 Antibodies), MKK7 (show MAP2K7 Antibodies), and MKK9, are responsible for the activation of MPK3 and MPK6 (show MAPK6 Antibodies) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (show MAPK1 Antibodies) signaling through MKK4 (show MAP2K4 Antibodies)/5/7/9-MPK3/6 cascades.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase