Browse our anti-Paxillin (PXN) Antibodies

Full name:: anti-Paxillin Antibodies (PXN)

On www.antibodies-online.com are 414 Paxillin (PXN) Antibodies from 30 different suppliers available. Additionally we are shipping Paxillin Kits (49) and Paxillin Proteins (15) and many more products for this protein. A total of 501 Paxillin products are currently listed.

Synonyms:: AW108311, AW123232, CG18061, CG18576, CG31794, CT40481, CT42454, Dmel\\CG31794, dPax, DpaxA, DPaxillin, DPxn, DPxn37, LOC100220858, pax, PDLP, PXN, wu:fw71f12

list all antibodies	Gene Name	GeneID	UniProt
	PXN	5829	P49023
	PXN	19303	Q8VI36
	PXN	360820	Q66H76
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Most Popular Reactivities for anti-Paxillin (PXN) Antibodies

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anti-Human Paxillin Antibodies:

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anti-Rat (Rattus) Paxillin Antibodies:

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Relevant Pathways for anti-Paxillin Antibodies

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Top referenced anti-Paxillin Antibodies

Human Polyclonal Paxillin Primary Antibody for IHC - ABIN966810 : Davidson, Veillette: PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates. in The EMBO journal 2001 (PubMed)
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Chicken Monoclonal Paxillin Primary Antibody for ICC, WB - ABIN3043666 : Zhu, Liu, Li, Liu, Wang, Sun, Xiong, Jiang, Zheng, Hu: Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. in Carcinogenesis 2014 (PubMed)
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Human Polyclonal Paxillin Primary Antibody for ICC, IHC (fro) - ABIN3044187 : Liu, Zhu, Xiong, Zheng, Hu, Qiu: Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells. in International journal of clinical and experimental pathology 2014 (PubMed)
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Human Paxillin Primary Antibody for IHC - ABIN966808 : Fleming, Bauersachs, Schäfer, Scholz, Aldershvile, Busse: Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
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Human Polyclonal Paxillin Primary Antibody for WB - ABIN362228 : Goldberg: Actin-based motility of intracellular microbial pathogens. in Microbiology and molecular biology reviews : MMBR 2001 (PubMed)
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Human Polyclonal Paxillin Primary Antibody for IF, WB - ABIN363106 : Burridge, Turner, Romer: Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. in The Journal of cell biology 1992 (PubMed)
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Human Polyclonal Paxillin Primary Antibody for PLA, WB - ABIN519564 : Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. in Molecular & cellular proteomics : MCP 2013 (PubMed)
Human Polyclonal Paxillin Primary Antibody for IHC - ABIN966809 : Sanders, Basson: p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV. in The Journal of biological chemistry 2005 (PubMed)
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More Antibodies against Paxillin Interaction Partners

Human Paxillin (PXN) interaction partners

Data suggest that FGFR3 (show FGFR3 Antibodies) with mutation found in patients with SADDAN (but not FGFR3 (show FGFR3 Antibodies) with mutation found in patients with TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin. (FGFR3 (show FGFR3 Antibodies) = fibroblast growth factor receptor 3 (show FGFR3 Antibodies); SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II)
overexpression of Paxillin significantly decreased tumor volume of colorectal cancer; miR (show MLXIP Antibodies)-24 was overexpressed in natural killer cells and inhibited paxillin expression.
XIST positively regulated PXN levels by sponging miR (show MLXIP Antibodies)-137 in vitro and in vivo. Collectively, our study provided the evidence for the cross-talk between XIST, miR (show MLXIP Antibodies)-137, and PXN, shedding light on the therapy for non-small cell lung cancer .
we herein demonstrated that frequent overexpression of PXN in cervical cancer was associated with advanced tumor stage, poor differentiation and metastasis, and poor predictive outcomes
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.
we collected paraffin specimens from 85 GBM patients and evaluated the expression pattern of paxillin. Notably, we found that discernable paxillin signals were detected in 67 out of 85 samples. Given that leading edge is critical for cancer cell migration, we propose that NA treatment may be developed into a potential therapy for malignant glioma
Pxn binding to the CD103 (show ITGAE Antibodies) cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8 (show CD8A Antibodies)(+) T-cell migratory behavior and effector functions.
FAK (show PTK2 Antibodies)-Src (show SRC Antibodies)-Paxillin system is a marker of unfavorable prognosis for human Neuroblastoma (show ARHGEF16 Antibodies) patients but also a promising therapeutic target.
Studies suggest that signaling pathways downstream of activated FAK (show PTK2 Antibodies) including paxillin will be important to study in the context of FAK (show PTK2 Antibodies) inhibition and other therapeutics to identify novel biomarkers.
REVIEW of the functions of paxillin in pathological conditions, particularly in cell migration

Mouse (Murine) Paxillin (PXN) interaction partners

the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1 (show CCND1 Antibodies).Cdk4 (show CDK4 Antibodies).
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin.
Kindlin-2 (show FERMT2 Antibodies) is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 (show RAC1 Antibodies) and supplying Rac1 (show RAC1 Antibodies) with the Arp2 (show AICDA Antibodies)/3 complex.
paxillin and FAK (show PTK2 Antibodies) function cell-autonomously to control migrating neuron morphology and speed during cortical development.
paxillin interacts with processed LC3 (show MAP1LC3A Antibodies) through a conserved LIR (show CD300C Antibodies) motif in the amino-terminal end of paxillin and that this interaction is regulated by oncogenic SRC (show SRC Antibodies) activity.
Data show that actomyosin cytoskeletal contractility is required for paxillin localization to developing somite boundaries.
paxillin and Hic-5 (show TGFB1I1 Antibodies) have both redundant and distinctive functions in invadosome formation.
Fyn (show FYN Antibodies) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin phosphorylation
Lithium therapy abrogated GSK3beta overactivity, blunted paxillin hyperphosphorylation, and reinstated actin cytoskeleton integrity in glomeruli associated with an early attenuation of podocyte foot process effacement.
Suggest paxillin up-regulation and phosphorylation as an important mechanism of vascular remodelling underlying pulmonary hypertension.

Fruit Fly (Drosophila melanogaster) Paxillin (PXN) interaction partners

Data indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin (show DNM1 Antibodies), and the homeobox protein (show HOXA1 Antibodies) Mirror.
New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone
Results identify a link between the focal adhesion protein paxillin and the Atg1 (show ULK1 Antibodies) kinase, which has been previously implicated in autophagy.
Data show that Pax genes are involved in the development of the anterior/posterior brain boundary zone during embryonic CNS development in Drosophila.

Xenopus laevis Paxillin (PXN) interaction partners

Paxillin has a role in meiosis and may be a general modulator of mitogen-activated protein kinase (show MAPK1 Antibodies) signaling
RING finger protein (show TRIM31 Antibodies) XRNF185 (show RNF185 Antibodies), which physically binds to paxillin and the proteasome. XRNF185 (show RNF185 Antibodies) destabilizes paxillin at focal adhesions and promotes mesodermal cell migration during convergent extension.

Zebrafish Paxillin (PXN) interaction partners

paxillin may function in adhesion during the morphogenesis of the early zebrafish embryo

Pig (Porcine) Paxillin (PXN) interaction partners

Role of Y118 paxillin phosphorylation and stimulated actin polymerization in carotid artery contraction.

Paxillin (PXN) Antigen Profile

Antigen Summary

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).

Alternative names and synonyms associated with Paxillin (PXN)

paxillin (PXN) antibody
paxillin (Pxn) antibody
Paxillin (Pax) antibody
paxillin S homeolog (pxn.S) antibody
paxillin a (pxna) antibody
paxillin (LOC696336) antibody
paxillin (pxn) antibody

AW108311 antibody
AW123232 antibody
CG18061 antibody
CG18576 antibody
CG31794 antibody
CT40481 antibody
CT42454 antibody
Dmel\\CG31794 antibody
dPax antibody
DpaxA antibody
DPaxillin antibody
DPxn antibody
DPxn37 antibody
LOC100220858 antibody
pax antibody
PDLP antibody
PXN antibody
wu:fw71f12 antibody

Protein level used designations for anti-Paxillin (PXN) Antibodies

, , , , , , , , , , , , , , , , , , , , , CG31794-PA CG31794-PB CG31794-PC CG31794-PD CG31794-PF CG31794-PG CG31794-PH CG31794-PJ CG31794-PK D-Paxillin Pax-PA Pax-PB Pax-PC Pax-PD Pax-PF Pax-PG Pax-PH Pax-PJ Pax-PK Paxillin-derived LIM-only protein paxillin myocardial ischemic preconditioning associated protein 7

GENE ID	SPECIES
5829	Homo sapiens
19303	Mus musculus
35215	Drosophila melanogaster
360820	Rattus norvegicus
395832	Gallus gallus
397826	Xenopus laevis
399546	Danio rerio
452303	Pan troglodytes
486299	Canis lupus familiaris
517456	Bos taurus
696336	Macaca mulatta
100053811	Equus caballus
100126846	Sus scrofa
100173313	Pongo abelii
100216044	Xenopus (Silurana) tropicalis
100220858	Taeniopygia guttata
100474505	Ailuropoda melanoleuca
100732427	Cavia porcellus
100353305	Oryctolagus cuniculus
101111491	Ovis aries musimon

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Show all anti-Paxillin (PXN) Antibodies with Pubmed References