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anti-Human RAF1 Antibodies:
anti-Rat (Rattus) RAF1 Antibodies:
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Human RAF1 Primary Antibody for IHC - ABIN966940
Gabriel, Bravery, Dougherty, Kayley, Malster, Scales: Vascular access: indications and implications for patient care. in Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2005
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Human Polyclonal RAF1 Primary Antibody for DB, ELISA - ABIN4369727
Gohlke, Kuhn, Case: Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach. in Proteins 2004
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Human Monoclonal RAF1 Primary Antibody for FACS, IHC - ABIN969559
Hofmann, Heinrich, Radziwill, Radziwil, Moelling: A short hairpin DNA analogous to miR-125b inhibits C-Raf expression, proliferation, and survival of breast cancer cells. in Molecular cancer research : MCR 2009
Show all 2 Pubmed References
Human Monoclonal RAF1 Primary Antibody for FACS, IHC - ABIN969560
Takezawa, Okamoto, Yonesaka, Hatashita, Yamada, Fukuoka, Nakagawa: Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. in Cancer research 2009
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Human Monoclonal RAF1 Primary Antibody for WB - ABIN260776
Chiloeches, Mason, Marais: S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. in Molecular and cellular biology 2001
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Virus Polyclonal RAF1 Primary Antibody for ICC, IF - ABIN4340713
Retallack, Di Lullo, Arias, Knopp, Laurie, Sandoval-Espinosa, Mancia Leon, Krencik, Ullian, Spatazza, Pollen, Mandel-Brehm, Nowakowski, Kriegstein, DeRisi: Zika virus cell tropism in the developing human brain and inhibition by azithromycin. in Proceedings of the National Academy of Sciences of the United States of America 2016
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Human Polyclonal RAF1 Primary Antibody for IF (p), IHC (p) - ABIN712706
Wu, Dong, Shi, Yu, Fu, Zhang, Cai, Zhao, Peng, Wu, Wu: Regulation of integrin ?V subunit expression by sulfatide in hepatocellular carcinoma cells. in Journal of lipid research 2013
Human Polyclonal RAF1 Primary Antibody for IP, IHC - ABIN222938
Ito, Nagayasu, Okumura-Noji, Lu, Nishida, Miura, Asai, Kheirollah, Nakaya, Yokoyama: Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. in Journal of lipid research 2007
Human Polyclonal RAF1 Primary Antibody for IHC, WB - ABIN361884
Dougherty, Müller, Ritt, Zhou, Zhou, Copeland, Conrads, Veenstra, Lu, Morrison: Regulation of Raf-1 by direct feedback phosphorylation. in Molecular cell 2005
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Human Polyclonal RAF1 Primary Antibody for IHC, WB - ABIN362494
Fabian, Daar, Morrison: Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. in Molecular and cellular biology 1993
Show all 7 Pubmed References
RAF1 may have a role in survival in hepatocellular carcinoma, and indicate whether sorafenib should be used as a postoperative adjuvant
Mutational activation of Kit-, Ras/Raf/Erk (show EPHB2 Antibodies)- and Akt (show AKT1 Antibodies)- pathways indicate the biological importance of these pathways and their components as potential targets for therapy.
Results indicate that des (show DES Antibodies)-gamma-carboxy prothrombin (show F2 Antibodies) (DCP (show ACE Antibodies)) antagonizes the inhibitory effects of Sorafenib on hepatocellular carcinoma (HCC (show FAM126A Antibodies)) through activation of the Raf/MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathways.
DiRas3 (show DIRAS3 Antibodies) binds to KSR1 (show KSR1 Antibodies) independently of its interaction with activated Ras and RAF.
RhoA (show RHOA Antibodies)/ROCK and Raf-1/CK2 (show CSNK2A1 Antibodies) pathway are responsible for TNF-alpha (show TNF Antibodies)-mediated endothelial cytotoxicity via regulation of the vimentin (show VIM Antibodies) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS.
This finding suggests that stringent assemblage of Hsp90 (show HSP90 Antibodies) keeps CRAF kinase equipped for participating in the MAPK (show MAPK1 Antibodies) pathway. Thus, the role of Hsp90 (show HSP90 Antibodies) in CRAF maturation and activation acts as a limiting factor to maintain the function of a strong client like CRAF kinase.
Oncogenic NFIA:RAF1 fusion activation of the MAPK (show MAPK1 Antibodies) pathway is associated with pilocytic astrocytoma.
IGF2BP2 (show IGF2BP2 Antibodies) as a post-transcriptional regulatory mRNA-binding factor, interfering with Raf-1 degradation by miR (show MLXIP Antibodies)-195, that contributes to Colorectal carcinogenesis.
cdk10 (show CDK10 Antibodies) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
data suggest that G alpha(i3), Shc (show SHC1 Antibodies), Grb2 (show GRB2 Antibodies), Ras, and Raf-1 link Src (show SRC Antibodies) to activation of MAPK (show MAPK1 Antibodies) and to the AT(2)-dependent increase in eNOS (show NOS3 Antibodies) expression in PAECs
BRAF (show BRAF Antibodies) and ROKalpha (show ROCK2 Antibodies) form independent RAF1 complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (show EGF Antibodies)).
Mechanistically, BRAF (show BRAF Antibodies) and RAF1 operate independently to balance MAPK (show MAPK1 Antibodies) signaling: BRAF (show BRAF Antibodies) promotes ERK (show EPHB2 Antibodies) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
A- and B-Raf (show SNRPE Antibodies) ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF (show VEGFA Antibodies) protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (show RPS6KA2 Antibodies) was increased in Raf1(L613V) mice. Constitutive RSK3 (show RPS6KA2 Antibodies) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (show EPHX2 Antibodies) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (show EPHX2 Antibodies) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (show PDX1 Antibodies)-Cre mice.
under normal physiological conditions, PTEN suppresses AKT (show AKT1 Antibodies) activity to maintain activation of the RAF1/ERK (show EPHB2 Antibodies) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
these data indicate that B-RAF (show SNRPE Antibodies) is an important factor in oncogenic C-RAF-mediated tumorigenesis.
Both c-Raf and B-Raf (show BRAF Antibodies) are required for Ras-induced MEK1 (show MAP2K1 Antibodies) and p42 (show EPB42 Antibodies) MAP kinase (show MAPK1 Antibodies) activation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF