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anti-Human SGK1 Antibodies:
anti-Mouse (Murine) SGK1 Antibodies:
anti-Rat (Rattus) SGK1 Antibodies:
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Human Polyclonal SGK1 Primary Antibody for IHC, IHC (p) - ABIN4353191
Wen, Wan, Ren, Zhou, Gao, Wu, Wang, Yuan, Zhou: Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. in Experimental and molecular pathology 2016
High SGK1 expression is associated with gastric cancer.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K (show PIK3CA Antibodies)-activating mutations.
miRNA-7-5p can regulate the expression of human alveolar ENaC (show SCNN1A Antibodies) by targeting the mTORC2 (show CRTC2 Antibodies)/SGK-1 signaling pathway.
TLR4 (show TLR4 Antibodies) and C5aR (show C5AR1 Antibodies) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Antibodies), PI3Kbeta, SGK1, and FOXO (show FOXO3 Antibodies) transcription factors.
Findings illustrate how cancer cells utilize a chromatin remodeling factor (show ASH1L Antibodies) to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1 (show MTA1 Antibodies)-SGK1 axis by a physiologic signal in cancer progression.
SGK1 inhibitor SI113 induced a significant reduction in endometrial cancer cells viability, as a result of induction of autophagy, apoptosis, and endoplasmic reticulum stress.
Findings show that serum and glucocorticoid-inducible kinase 1 (SGK1) protein dynamics can be an important part of intracellular signaling, directly influencing cellular response decisions.
In cancer cells resistant to PI3Kalpha (show PIK3CA Antibodies) inhibition, PDK1 (show PDK1 Antibodies) blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1 (show PDK1 Antibodies), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (show TSC2 Antibodies).
SGK1 promotes YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) transcriptional activity. SGK1 enhances YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) activity by upregulating YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies). SGK1 is a transcriptional target of YAP (show YAP1 Antibodies). SGK1 stabilizes TAZ (show TAZ Antibodies) by inhibiting GSK3beta (show GSK3b Antibodies).
Potassium supplementation has a blocking effect against salt-loading-induced IL-17A (show IL17A Antibodies) production in T lymphocytes, and the protective effect was mediated through suppression of p38/MAPK (show MAPK14 Antibodies)-SGK1 pathway.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations.
Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion
our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2 (show NEDD4L Antibodies), WNK1 (show WNK1 Antibodies), and ENaC (show SCNN1A Antibodies)
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor (show NR3C2 Antibodies) deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1 (show JUN Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathways.
Akt3 (show AKT3 Antibodies) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Antibodies)/SGK1/Cdc42 (show CDC42 Antibodies) pathway.
SGK1 and SGK3 (show SGK3 Antibodies) are expressed in multiple microglial cell lines. SGK1 and SGK3 (show SGK3 Antibodies) may play an important role in regulating microglial viability and inflammatory responses.
The data indicate that the balanced activities of two related serine/threonine kinases, AKT (show AKT1 Antibodies) and SGK1, critically govern the embryo implantation process.
LEFTY2 (show LEFTY2 Antibodies) regulates the expression and activity of ENaC (show SCNN1A Antibodies) in endometrial epithelial cells via SGK1.
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase