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Human Polyclonal SGK1 Primary Antibody for IHC, IHC (p) - ABIN4353191
Wen, Wan, Ren, Zhou, Gao, Wu, Wang, Yuan, Zhou: Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. in Experimental and molecular pathology 2016
Sgk1 stimulated OAT3 (show SLC22A8 Antibodies) transport activity by interfering with the inhibitory effect of Nedd4-2 (show NEDD4L Antibodies) on the transporter. This study provides important insights into how OAT3 (show SLC22A8 Antibodies)-mediated drug elimination is regulated in vivo.
Decreased expression of SGK1 may play a critical role in increasing the expression of alpha-syn, which is related with dopaminergic cell death in the Substantia nigra of chronic MPTP (show PTPN2 Antibodies)-induced Parkinsonism mice and in SH-SY5Y cells.
Taken together, our results suggest that SGK1 inhibits PM2.5-induced cell apoptosis and ROS (show ROS1 Antibodies) generation via ERK1/2 and AKT (show AKT1 Antibodies) signaling pathway in human lung alveolar epithelial A549cells.
High SGK1 expression is associated with gastric cancer.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K (show PIK3CA Antibodies)-activating mutations.
miRNA-7-5p can regulate the expression of human alveolar ENaC (show SCNN1A Antibodies) by targeting the mTORC2 (show CRTC2 Antibodies)/SGK-1 signaling pathway.
TLR4 (show TLR4 Antibodies) and C5aR (show C5AR1 Antibodies) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Antibodies), PI3Kbeta, SGK1, and FOXO (show FOXO3 Antibodies) transcription factors.
Findings illustrate how cancer cells utilize a chromatin remodeling factor (show ASH1L Antibodies) to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1 (show MTA1 Antibodies)-SGK1 axis by a physiologic signal in cancer progression.
SGK1 inhibitor SI113 induced a significant reduction in endometrial cancer cells viability, as a result of induction of autophagy, apoptosis, and endoplasmic reticulum stress.
Findings show that serum and glucocorticoid-inducible kinase 1 (SGK1) protein dynamics can be an important part of intracellular signaling, directly influencing cellular response decisions.
High SGK1 expression is associated with anxiety/depression.
Experiments showed a dynamic change of immune inflammation, oxidative stress and p38MAPK (show MAPK14 Antibodies)-SGK1 pathway involvement in EAE demonstrating that p38MAPK (show MAPK14 Antibodies)-SGK1 pathway and oxidative stress contribute to the demyelination in central nerve system caused by Th17 inflammatory responses in a synergistic way.
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations.
Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion
our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2 (show NEDD4L Antibodies), WNK1 (show WNK1 Antibodies), and ENaC (show SCNN1A Antibodies)
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor (show NR3C2 Antibodies) deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1 (show JUN Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathways.
Akt3 (show AKT3 Antibodies) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Antibodies)/SGK1/Cdc42 (show CDC42 Antibodies) pathway.
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase