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anti-Human SGK1 Antibodies:
anti-Mouse (Murine) SGK1 Antibodies:
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Mouse (Murine) Polyclonal SGK1 Primary Antibody for IHC, WB - ABIN3021291
Li, Zhou, Yang, Li, Zhang, Wang, Jiao: SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells. in Biochemical and biophysical research communications 2018
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Human Polyclonal SGK1 Primary Antibody for IHC, WB - ABIN6672369
: Retracted: 'Anti-fibrotic actions of Ghrelin by inhibition of the NADPH oxidase-ROS signaling pathway' by Qian Wang, Xin Sui, Rui Chen, Peiyong Ma, Tao Ding, Dianjun Sui, and Ping Yang. in Clinical and experimental pharmacology & physiology 2018
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Human Polyclonal SGK1 Primary Antibody for ICC, IHC (p) - ABIN3044488
Chang, Bok, Sun, Edwards, Huang: Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress. in PLoS genetics 2017
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Human Polyclonal SGK1 Primary Antibody for IHC, IHC (p) - ABIN4353191
Wen, Wan, Ren, Zhou, Gao, Wu, Wang, Yuan, Zhou: Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway. in Experimental and molecular pathology 2016
Study finds that Src positively regulates SGK1 expression in triple negative breast cancer cells, which exhibit a prominent signalling network governed by Src family kinases.
Studies indicate that aldosterone-sensitive distal nephron (ASDN) expressed channels are up-regulated by serum and glucocorticoid regulated kinase 1 (SGK1).
The importance of the serum and glucocorticoid-regulated kinase 1 (SGK1) for cellular survival was validated in multiple patient-derived GBM stem cell lines using shRNA, CRISPR, and pharmacologic inhibitors.
Fewer Tumor Copy Number Segments of the SGK1 Gene Are Associated with Glioblastoma Multiforme.
High SGK1 expression is associated with non-small cell lung cancer.
Here the authors show that SGK1 directly regulates NaV1.5 channel function.
Sgk1 stimulated OAT3 transport activity by interfering with the inhibitory effect of Nedd4-2 on the transporter. This study provides important insights into how OAT3-mediated drug elimination is regulated in vivo.
Decreased expression of SGK1 may play a critical role in increasing the expression of alpha-syn, which is related with dopaminergic cell death in the Substantia nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells.
Taken together, our results suggest that SGK1 inhibits PM2.5-induced cell apoptosis and ROS generation via ERK1/2 and AKT signaling pathway in human lung alveolar epithelial A549cells.
High SGK1 expression is associated with gastric cancer.
associated with risk of hypertension development in Chinese
SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations.
miRNA-7-5p can regulate the expression of human alveolar ENaC by targeting the mTORC2/SGK-1 signaling pathway.
TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kbeta, SGK1, and FOXO transcription factors.
Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression.
SGK1 inhibitor SI113 induced a significant reduction in endometrial cancer cells viability, as a result of induction of autophagy, apoptosis, and endoplasmic reticulum stress.
Findings show that serum and glucocorticoid-inducible kinase 1 (SGK1) protein dynamics can be an important part of intracellular signaling, directly influencing cellular response decisions.
In cancer cells resistant to PI3Kalpha inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.
SGK1 promotes YAP/TAZ transcriptional activity. SGK1 enhances YAP/TAZ activity by upregulating YAP/TAZ. SGK1 is a transcriptional target of YAP. SGK1 stabilizes TAZ by inhibiting GSK3beta.
Potassium supplementation has a blocking effect against salt-loading-induced IL-17A production in T lymphocytes, and the protective effect was mediated through suppression of p38/MAPK-SGK1 pathway.
SGK1 influences migration of VSMC by transcriptional regulation of Ca2+ channel Orai1 expression, an effect requiring SGK1-dependent activation of transcription factor NF-B after arterial injury.
results suggest that SGK1 may play a critical role in the inflammatory cascade of cardiac fibroblasts triggered by mechanical stretch; SGK1 could be used as a potential target for treatment of cardiac fibrosis and heart failure
High SGK1 expression is associated with anxiety/depression.
Experiments showed a dynamic change of immune inflammation, oxidative stress and p38MAPK-SGK1 pathway involvement in EAE demonstrating that p38MAPK-SGK1 pathway and oxidative stress contribute to the demyelination in central nerve system caused by Th17 inflammatory responses in a synergistic way.
Altered K balance in animals lacking SGK1 may reflect defects in epithelial Na channel -independent K excretion
our data suggest that renal tubular SGK1 is important in the regulation of K(+) excretion via the control of NEDD4-2, WNK1, and ENaC
SGK1 is similarly involved in the regulation of cell volume and cell fluid transport.
Mineralocorticoid receptor deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via SGK1-AP1/NF-kappaB pathways.
Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway.
SGK1 and SGK3 are expressed in multiple microglial cell lines. SGK1 and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
The data indicate that the balanced activities of two related serine/threonine kinases, AKT and SGK1, critically govern the embryo implantation process.
LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.
high levels of resistin observed during obesity may activate SGK1 in the vasculature and contribute to the development of obesity-related vascular disease
High salt diet may deteriorate lupus nephritis through SGK1 pathway.
Study shows that SGK1 impairs nuclear abundance of p27 and suggests that phosphorylation of p27T197 by SGK1 is required for cardiac hypertrophy.
SGK1 appears to be an important enzyme in the process of fibrotic remodeling and subsequent weakness of dystrophin-deficient mouse muscle
The characterisation of SGK1 functions in obesity and immunity may help identify potential therapeutic targets in the treatment of obesity.
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Sgk1 variant i3
, serine/threonine protein kinase SGK
, serine/threonine-protein kinase Sgk1
, serum/glucocorticoid-regulated kinase 1
, serum and glucocorticoid-dependent protein kinase
, serum/glucocorticoid regulatory kinase
, serum- and glucocorticoid-induced kinase
, serum and glucocorticoid-regulated protein kinase