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anti-Mouse (Murine) Vinexin Antibodies:
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These observations reveal a critical role of vinexin alpha and CAP in mechanotransduction and MSC differentiation.
Differential roles of SORBS proteins in mechanotransduction.
Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis.
The results indicate that lipid rafts play an important role in extracellular matrix stiffness regulation of cell migration via expression vinculin and its interaction with vinexin alpha.
Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury
Vinexin-beta increases myocardial infarction-induced mortality and worsens cardiac dysfunction through aggravation of myocardial apoptosis and inflammatory response.
In the absence of retinoic acid (RA), vinexinbeta does not occupy RARgamma target gene promoters and sequesters nonphosphorylated RARgamma out of promoters
vinexin (-/-) mice exhibited a delay in cutaneous wound healing in both the back skin and tail without affecting the proliferation of keratinocytes
regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor
vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation
phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta
gamma isoform seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in fetal gonads
vinexins are recruited to focal adhesions by activated vinculin
Data report the identification of the cytoskeletal protein vinexin as a protein interacting with SHIP2.
The testicular vinexin pattern underwent significant changes after developmental exposure to 17beta-estradiol (E(2)).
v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin.
vinexin alpha is tyrosine phosphorylated in v-Src-transformed cells, and this tyrosine phosphorylation of vinexin alpha attenuates the association of vinexin alpha with vinculin.
The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells.
Study identified possible epigenetic influence on differential gene expression in SORBS3 under obese conditions.
Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle.
Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation.
regulates cytoskeletal organization and signal transduction--review
These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl.
Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells.
Rhotekin forms a complex with vinexin and may play a role at focal adhesions.
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
sorbin and SH3 domain containing 3
, vinexin beta (SH3-containing adaptor molecule-1)
, SH3 domain protein 4
, SH3 domain-containing protein SH3P3
, SH3-containing adapter molecule 1
, vinexin alpha
, vinexin beta
, sorbin and SH3 domain-containing protein 3