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Human YAP1 Protein expressed in Wheat germ - ABIN1325497
Zhao, Zhou, Xue, Zhang, Zhan: Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). in PLoS ONE 2014
O-GlcNAcylation of YAP was required for high-glucose-induced liver tumorigenesis.
These results unveil a novel mechanism of YAP activation in cancer and open the possibility to target GR to prevent cancer stem cells self-renewal and chemoresistance.
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Proteins) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Proteins)) elasticity and cell shape.
High YAP1 expression is associated with the pathogenesis of gastric cancer.
YAP1 as a fluid mechanosensor that functions to regulate genes that promote metastasis.
These observations revealed the importance of YAP in promoting TKI-resistance and combined YAP inhibition can be a potential therapy delaying the occurrence of TKI-resistance in lung adenocarcinoma.
High Yap expression is associated with resistance to EGFR (show EGFR Proteins) inhibitors in colorectal cancer.
High YAP1 expression is associated with malignant melanoma.
Data (including data from studies in knockout mice) suggest that KIBRA (show WWC1 Proteins) plays important role in regulating HPO (show GFER Proteins) activity, YAP signaling, and actin cytoskeletal dynamics in podocytes; expression of KIBRA (show WWC1 Proteins) and YAP plus phosphorylation of YAP are up-regulated in glomeruli of patients with focal segmental glomerulosclerosis. (KIBRA (show WWC1 Proteins) = kidney/brain protein-KIBRA (show WWC1 Proteins); HPO (show GFER Proteins) = hepatopoietin protein (show GFER Proteins); YAP = Yes associated protein-1)
YAP/TAZ (show TAZ Proteins) mechanotransduction integrates with cell-cell communication pathways for fine-grained orchestration of stem cell decisions.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.
Nuclear expression of YAP1 is detected in a small subset of hepatic cells starting at embryonic day (E) 13.5 when the hepatoblasts begin to differentiate into hepatocytes and cholangiocytes. At E18.5, nuclear YAP1 is undetectable in hepatoblasts & hepatocytes, but enriched within the nuclei of cholangiocytes. These levels remain postnatally, consistent with the role of YAP1 in cholangiocyte specification and maintenance.
The results indicate that EGFR (show EGFR Proteins) and its activation are critical for YAP-mediated suppression of TGF-beta1 (show TGFB1 Proteins)-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1 (show TGFB1 Proteins)-mediated simultaneous apoptosis and epithelial mesenchymal transformation.
Fat4 is not required for the canonical activation of Hippo kinases but it sequesters a partner of Yap1, Amotl1, out of the nucleus.
Functional impairment of YAP/YAPdeltaC by mutant Atxn1 during development determines the adult pathology of spinocerebellar ataxia type 1 by suppressing RORalpha-mediated transcription.
Low YAP expression is associated with low liver regeneration.
these observations suggest that Zyxin (show ZYX Proteins) promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8 (show CDK8 Proteins)-mediated YAP activation.
During and after liver development, the activation of YAP/TAZ induced by loss of Lats1/2 forces hepatoblasts or hepatocytes to commit to the biliary epithelial cell lineage.
YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3 (show CRB3 Proteins), localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth.
The authors show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 (show WWTR1 Proteins) are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin (show FN1 Proteins) assembly underneath the presumptive epidermis and surrounding the notochord.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Proteins) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1 (show LEF1 Proteins).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa