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Human YAP1 Protein expressed in Wheat germ - ABIN1325497
Zhao, Zhou, Xue, Zhang, Zhan: Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). in PLoS ONE 2014
Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression.
Findings demonstrate for the first time that S100A7 (show S100A7 Proteins) is repressed by YAP via the Hippo pathway.
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Proteins) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Proteins)) elasticity and cell shape.
Collectively, our results defined netrin-1 (show NTN1 Proteins) as a positive regulator of malignant tumor metastasis in GC by activating the YAP signaling, with potential implications for new approaches to GC therapy.
The authors propose that phosphorylation of Amot (show AMOT Proteins)(S176) is a critical post-translational modification that suppresses YAP's ability to promote cell proliferation and tumorigenesis by altering the subcellular localization of an essential YAP co-factor.
YAP maintains human embryonic stem cells pluripotency by preventing WNT3 expression in response to Activin, thereby blocking a direct route to embryonic cardiac mesoderm formation.
These results demonstrate a critical role of the activation of YAP/TAZ (show TAZ Proteins) by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development.
the complex structure of YAP WW2 domain with a high-affinity peptide was modeled and examined in detail, which was then used to guide structure-based peptide optimization to obtain several strong domain binders.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (show MST1 Proteins)/2)/YAP signaling, and that inhibition of miR (show MLXIP Proteins)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (show SOX2 Proteins) and SALL4 (show SALL4 Proteins).
miR (show MLXIP Proteins)-138 may play a suppressive role in the growth and metastasis of non small cell lung cancer cells partly at least by targeting YAP1
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
The authors show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties.
Decrease in actin tension and YAP inactivation should be crucially involved in the cytotoxicity of ethanol on HL-1 (show ASGR1 Proteins) cardiomyocytes.
The results of this study indicated that YAP regulates oligodendrocyte morphology and maturation in response to mechanical factors.
Study found that the extracellular matrix protein laminin-511 (show LAMA5 Proteins) (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP.
YAP accumulated in nuclei of mammary glands in ErbB2 (show ERBB2 Proteins)/EGFR (show EGFR Proteins)-transgenic mice, suggesting that EGFR (show EGFR Proteins) signaling affects YAP in vivo similar to cell culture. ErbB2 (show ERBB2 Proteins)/EGFR (show EGFR Proteins)-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Therefore, YAP/TAZ (show TAZ Proteins) are crucial for Schwann cells to myelinate developing nerve and to maintain myelinated nerve in adulthood.
Collectively, we have uncovered that AMOT (show AMOT Proteins) acts as a YAP stimulator in high glucose level.
YAP1 enhanced cementoblast mineralization in vitro. YAP1 exerted its effect on the cementoblast partly by regulating the Smad-dependent BMP and Erk1/2 signaling pathways.
A crucial role for YAP and TAZ (show TAZ Proteins) in the maintenance of the postnatal adrenal cortex.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Proteins) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1 (show LEF1 Proteins).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa