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Human YAP1 Protein expressed in Wheat germ - ABIN1325497
Zhao, Zhou, Xue, Zhang, Zhan: Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). in PLoS ONE 2014
YAP contributes to glioma cell migration and invasion by regulating N-cadherin (show CDH2 Proteins) and Twist, as well as cytoskeletal reorganization.
LIFR (show LIFR Proteins) attenuates tumor metastasis by suppressing YAP expression, suggesting that LIFR (show LIFR Proteins) may serve as a potential target for clear cell renal cell carcinoma (show MOK Proteins) treatment.
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Proteins) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Proteins)) elasticity and cell shape.
Serine/threonine-protein kinase (show PRKACG Proteins) proteins, also known as P21 (show CDKN1A Proteins)-activated kinase (PAK), and the mechanosensitive factor, Yes-associated protein 1 (YAP-1) are core mediators of pro-fibrotic integrin beta-1 (show ITGB1 Proteins) signaling.
Loss of Yap reduced SIRT1 (show SIRT1 Proteins) expression and inhibited Mfn2 (show MFN2 Proteins)-mediated mitophagy. Collectively, our results identified Hippo-Yap as a tumor promoter in gastric cancer that was mediated via activation of the SIRT1 (show SIRT1 Proteins)/Mfn2 (show MFN2 Proteins)/mitophagy axis, with potential applications to gastric cancer therapy involving cancer survival and migration.
The gene transcription and protein expression of YAP may be involved in the development of prostate cancer and may be considered a potential target for the treatment of such cancers.
Upregulated miR (show MLXIP Proteins)-200a enhances treatment resistance via antagonizing TP53INP1 and YAP1 in breast cancer.
Bioinformatics analysis and luciferase reporter assays indicated that miR625 targeted the 3'untranslated region of Yesassociated protein 1 (YAP1).
functional evaluation of a HTM cell monolayer using a permeability assay demonstrated that the inhibition of YAP and TAZ (show TAZ Proteins) attenuated the DEX-induced impairment of permeability. These findings suggest that YAP and TAZ (show TAZ Proteins) play pivotal roles in the DEX-induced cytoskeletal changes of HTM cells, and reveal novel potential mechanisms for the development and progression of glaucoma
the role of YAP in deciding cell competitions depends on metabolic factors and the status of neighboring cells
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3 (show CRB3 Proteins), localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth.
The YAP/TEAD1 (show TEAD1 Proteins) complex binds to DNA element and regulates the expression of genes involved in cell growth..our data demonstrate an important role of TEAD1 (show TEAD1 Proteins) in early development in mice, and the floxed TEAD1 (show TEAD1 Proteins) mouse model will be a valuable genetic tool to determine the temporal and tissue-specific functions of TEAD1 (show TEAD1 Proteins).
RHOA (show RHOA Proteins) loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG (show EREG Proteins)) expression in the crypts. Expression of an active YAP (S112A) mutant rescues ntestinal stem cells (ISCs (show NFS1 Proteins)) marker expression, ISC regeneration, and ISC-associated Wnt (show WNT2 Proteins) signaling, but not defective epithelial polarity, in RhoA (show RHOA Proteins) knockout mice, implicating YAP in RHOA (show RHOA Proteins)-regulated ISC function.
YAP promotes the neurite outgrowth via targeting the promoter of miR (show MLXIP Proteins)-29a, and it may be an effective therapeutic medicine for the neural disease.
Plk2 (show PLK2 Proteins) acts as coordinator of cell proliferation and early lineage commitment in cardiac progenitor cells downstream of Yes-associated protein 1.
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.
MOB1 (show HOPX Proteins)-dependent YAP1/TAZ (show TAZ Proteins)-TEAD complex functions as a transcriptional repressor of SOX9 (show SOX9 Proteins) and thereby negatively regulates chondrogenesis.
Hedgehog (show SHH Proteins)-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells and their transdifferentiation into myofibroblasts.
The role of Yap and Wwtr1 (show WWTR1 Proteins) in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.
demonstrated the nuclear expression of transcriptional coactivator YAP1 in the limbal and corneal basal epithelial cells and its essential role for maintaining the high proliferative potential of those corneal epithelial progenitor cells in vivo
The authors show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 (show WWTR1 Proteins) are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin (show FN1 Proteins) assembly underneath the presumptive epidermis and surrounding the notochord.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Proteins) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1 (show LEF1 Proteins).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa