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This study which performed for the first time in Iran suggests that polymorphism in CGA gene can affect male infertility.
Our findings support a model in which CREB3L1 acts as a downstream effector of TSH to regulate the expression of cargo proteins, and simultaneously increases the synthesis of transport factors and the expansion of the Golgi to synchronize the rise in cargo load with the amplified capacity of the secretory pathway
men with higher and women with lower serum TSH levels are at increased risk of frailty.
Inhibin-B secretion and FSH (show BRD2 Proteins) isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review)
proteomic study reveals unique protein changes in both cellular (98% unique identifications) and secreted (96% unique identifications) proteins in the transition to the progesterone-dominated secretory (receptive) phase and subsequently to pregnancy, mediated by embryo-derived human chorionic gonadotropin (hCG)
the in vivo bioactivities of FSH (show BRD2 Proteins) glycoforms in Fshb (show FSHB Proteins) null mice using a pharmacological rescue approach, was investigated.
the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.
The present results have for the first time shown protective effects exerted by hCG on vascular endothelial function.
Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT (show GALT Proteins).
TBP (show TBP Proteins) attenuates Msx1 (show MSX1 Proteins)-mediated glycoprotein hormone alpha transcriptional repression.
These results demonstrate that elevated TSH can promote endothelial dysfunction by altering gene expression in human umbilical vein endothelial cells.
Neurotrophin 4 (show NTF4 Proteins) may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins.
Data suggest that expression of Rps6ka5 (show RPS6KA5 Proteins) in gonadotroph cell line is up-regulated by GnRH (show GNRH1 Proteins) signaling and is required for Cga expression; GnRH (show GNRH1 Proteins)-activates Rps6ka5 (show RPS6KA5 Proteins) targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5 (show RPS6KA5 Proteins)= mitogen and stress-activated protein kinase 1 (show RPS6KA5 Proteins); GnRH (show GNRH1 Proteins) = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit (show POLG Proteins))
TSH improves insulin (show INS Proteins) sensitivity in skeletal muscle by increasing Irs1 (show IRS1 Proteins) gene expression.
Oncogene (show RAB1A Proteins)-induced senescence is initiated in Braf (show BRAF Proteins)(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 (show TP53 Proteins) expression by upregulating the PI3K/AKT (show AKT1 Proteins) pathway and inhibiting OIS, resulting in tumor progression.
the Cga eRNA mediates the physical interaction between genomic regions and determines the chromatin structure of the proximal promoter to allow gene expression
Data suggest that highly bioactive luteinizing hormone (LH; both alpha [Cga] and beta [Lhb (show LHB Proteins)] subunits) is produced by embryo/blastocyst at time of implantation; LH bioactivity remains constant in blastocyst on days 5-10 after fertilization.
Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU is increased by let7b/c through downregulation of KSRP (show KHSRP Proteins)
results suggest that in alphaT3-1 cells, dopamine D(2) receptors negatively regulate pituitary gonadotropin alpha subunit (show POLG Proteins) gene expression in association with the cAMP-dependent pathway
These results suggest that ADCYAP1 (show ADCYAP1 Proteins) mainly increases Cga through activation of PKA and MAPK3 (show MAPK3 Proteins)/1, as well as through an additional unknown pathway.
BMP4 (show BMP4 Proteins) stimulates CG secretion by chorionic girdle trophoblast cells.
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene.
, anterior pituitary glycoprotein hormones common subunit alpha
, choriogonadotropin alpha chain
, chorionic gonadotrophin subunit alpha
, chorionic gonadotropin, alpha polypeptide
, follicle-stimulating hormone alpha chain
, follicle-stimulating hormone alpha subunit
, follitropin alpha chain
, glycoprotein hormones alpha chain
, luteinizing hormone alpha chain
, lutropin alpha chain
, thyroid-stimulating hormone alpha chain
, thyrotropin alpha chain
, glycoprotein hormone alpha-subunit
, TSH alpha
, thyrotropin alpha subunit
, pituitary glycoprotein hormone alpha subunit
, glycoprotein hormones, alpha subunit
, chorionic gonadotropin, alpha chain
, glycoprotein hormones, alpha polypeptide
, pituitary hormone alpha subunit
, equine chorionic gonadotropin alpha-subunit
, LH alpha 3
, precursor polypeptide
, Anterior pituitary glycoprotein hormones common subunit alpha
, Choriogonadotropin alpha chain
, Chorionic gonadotrophin subunit alpha
, Follicle-stimulating hormone alpha chain
, Follitropin alpha chain
, Luteinizing hormone alpha chain
, Lutropin alpha chain
, Thyroid-stimulating hormone alpha chain
, Thyrotropin alpha chain
, chorionic gonadotropin alpha
, Glycoprotein hormones alpha chain
, glycoprotein hormone alpha subunit
, glycoprotein hormones, alpha polypeptide L homeolog
, lycoprotein hormones, alpha polypeptide
, gonadotropin alpha subunit