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This study which performed for the first time in Iran suggests that polymorphism in CGA gene can affect male infertility.
Our findings support a model in which CREB3L1 acts as a downstream effector of TSH to regulate the expression of cargo proteins, and simultaneously increases the synthesis of transport factors and the expansion of the Golgi to synchronize the rise in cargo load with the amplified capacity of the secretory pathway
men with higher and women with lower serum TSH levels are at increased risk of frailty.
Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review)
proteomic study reveals unique protein changes in both cellular (98% unique identifications) and secreted (96% unique identifications) proteins in the transition to the progesterone-dominated secretory (receptive) phase and subsequently to pregnancy, mediated by embryo-derived human chorionic gonadotropin (hCG)
the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated.
In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3).
the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.
The present results have for the first time shown protective effects exerted by hCG on vascular endothelial function.
Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT.
thyroid-stimulating hormone elevations can obviously be the initial finding in pseudohypoparathyroidism type Ib patients.
TBP attenuates Msx1-mediated glycoprotein hormone alpha transcriptional repression.
The results indicate that gal-3 might be regulated by Human chorionic gonadotropin (hCG)in preparing the endometrium for embryonic implantation.
Limitations in the process of transcription and translation inhibit recombinant human chorionic gonadotropin expression in CHO cells.
the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of AMPK directly inhibited the expression of SREBP-2 and HMGCR and HMGCS, and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells.
Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex.
A single low TSH at baseline was associated with increased risk of hip fractures (adj HR 1.16, 95% CI 1.07-1.26, p < 0.001) but not major osteoporotic fractures (MOF, adj HR 1.06, 95% CI 0.99-1.12, p = 0.058) over a median follow-up of 7.5 years.
This study showed a link between low maternal serum hCG levels and cryptorchidism in boys from uncomplicated pregnancy.
A protective effect of hCG against breast cancer may be associated with its growth inhibitory and differentiation induction function in breast cancer cells.
LH, progesterone, and TSH can stimulate aldosterone.
These results demonstrate that elevated TSH can promote endothelial dysfunction by altering gene expression in human umbilical vein endothelial cells.
Neurotrophin 4 may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins.
Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit)
TSH improves insulin sensitivity in skeletal muscle by increasing Irs1 gene expression.
Oncogene-induced senescence is initiated in Braf(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 expression by upregulating the PI3K/AKT pathway and inhibiting OIS, resulting in tumor progression.
the Cga eRNA mediates the physical interaction between genomic regions and determines the chromatin structure of the proximal promoter to allow gene expression
Data suggest that highly bioactive luteinizing hormone (LH; both alpha [Cga] and beta [Lhb] subunits) is produced by embryo/blastocyst at time of implantation; LH bioactivity remains constant in blastocyst on days 5-10 after fertilization.
Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH.
We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU is increased by let7b/c through downregulation of KSRP
results suggest that in alphaT3-1 cells, dopamine D(2) receptors negatively regulate pituitary gonadotropin alpha subunit gene expression in association with the cAMP-dependent pathway
These results suggest that ADCYAP1 mainly increases Cga through activation of PKA and MAPK3/1, as well as through an additional unknown pathway.
BMP4 stimulates CG secretion by chorionic girdle trophoblast cells.
gsualpha:EGFP transgenic zebrafish serve as a novel platform to perform screenings of endocrine-disrupting chemicals.
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene.
, anterior pituitary glycoprotein hormones common subunit alpha
, choriogonadotropin alpha chain
, chorionic gonadotrophin subunit alpha
, chorionic gonadotropin, alpha polypeptide
, follicle-stimulating hormone alpha chain
, follicle-stimulating hormone alpha subunit
, follitropin alpha chain
, glycoprotein hormones alpha chain
, luteinizing hormone alpha chain
, lutropin alpha chain
, thyroid-stimulating hormone alpha chain
, thyrotropin alpha chain
, glycoprotein hormone alpha-subunit
, TSH alpha
, thyrotropin alpha subunit
, pituitary glycoprotein hormone alpha subunit
, glycoprotein hormones, alpha subunit
, chorionic gonadotropin, alpha chain
, glycoprotein hormones, alpha polypeptide
, pituitary hormone alpha subunit
, equine chorionic gonadotropin alpha-subunit
, LH alpha 3
, precursor polypeptide
, Anterior pituitary glycoprotein hormones common subunit alpha
, Choriogonadotropin alpha chain
, Chorionic gonadotrophin subunit alpha
, Follicle-stimulating hormone alpha chain
, Follitropin alpha chain
, Luteinizing hormone alpha chain
, Lutropin alpha chain
, Thyroid-stimulating hormone alpha chain
, Thyrotropin alpha chain
, chorionic gonadotropin alpha
, Glycoprotein hormones alpha chain
, glycoprotein hormone alpha subunit
, glycoprotein hormones, alpha polypeptide L homeolog
, lycoprotein hormones, alpha polypeptide
, gonadotropin alpha subunit