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Human Polyclonal CYP24A1 Primary Antibody for ELISA, WB - ABIN560551
Peng, Jhaveri, Hussain-Hakimjee, Mehta: Overexpression of ER and VDR is not sufficient to make ER-negative MDA-MB231 breast cancer cells responsive to 1alpha-hydroxyvitamin D5. in Carcinogenesis 2007
Show all 2 Pubmed References
Human Monoclonal CYP24A1 Primary Antibody for ELISA, WB - ABIN514852
Helvig, Cuerrier, Hosfield, Ireland, Kharebov, Kim, Ramjit, Ryder, Tabash, Herzenberg, Epps, Petkovich: Dysregulation of renal vitamin D metabolism in the uremic rat. in Kidney international 2010
Human Polyclonal CYP24A1 Primary Antibody for ELISA, WB - ABIN4301729
Shen, Bielak, Ferguson, Streeten, Yerges-Armstrong, Liu, Post, OConnell, Hixson, Kardia, Sun, Jhun, Wang, Mehta, Li, Koller, Hakonarson, Keating, Rader, Shuldiner, Peyser, Reilly, Mitchell: Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. in Arteriosclerosis, thrombosis, and vascular biology 2010
Human Polyclonal CYP24A1 Primary Antibody for ICC, IF - ABIN4301730
Smolders, Schuurman, van Strien, Melief, Hendrickx, Hol, van Eden, Luchetti, Huitinga: Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue. in Journal of neuropathology and experimental neurology 2013
colorectal cancer (CRC (show CALR Antibodies)) patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 and CYP27B1 (show CYP27B1 Antibodies). Polymorphic genotypes cause a lower correlation between the forms of vitamin D.
Single nucleotide polymorphisms in CYP24A1 has a statistically significant association with risk of the colonic polyps, colon cancer, and ulcerative colitis in a Chinese population.
The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D.
Dietary habits, lifestyle, and polymorphisms in VDR (show CYP27B1 Antibodies) (ApaI), CYP24A1 (rs6013897, rs158552, rs17217119) and CYP27B1 (show CYP27B1 Antibodies) (rs10877012) were associated with a higher risk of colorectal cancer
The local regulation of vitamin D in sinonasal tissue during chronic rhinosinusitis may be independent of serum 25(OH)D levels. Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 (show CYP27B1 Antibodies) and increased transcription of the catabolic gene CYP24A1.
High CYP24A1 expression is associated with Lung Adenocarcinoma.
More recent evidence has identified loss of function mutations in CYP24A1 in association with hypercalcemia, hypercalciuria and nephrolithiasis in humans. [review]
Uremic serum increased the intracellular expression of IL-6 (show IL6 Antibodies), IFN-gamma (show IFNG Antibodies), TLR7 (show TLR7 Antibodies), TLR9 (show TLR9 Antibodies), VDR (show CYP27B1 Antibodies), CYP27b1 (show CYP27B1 Antibodies) and CYP24a1
Biallelic mutations in CYP24A1 or SLC34A1 were associated with infantile idiopathic hypercalcemia with vitamin D hypersensitivity
CYP24A1 association with the susceptibility of esophageal squamous cell carcinoma in a Northern Chinese population.
CYP24A1 activity is not essential for intramembranous bone formation.
results link CYP24 activity to the pathophysiology of FGF23 (show FGF23 Antibodies)-dependent renal phosphate wasting states and implicate pharmacologic CYP24 inhibition as a therapeutic adjunct for their treatment.
Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase mRNA levels and for maintaining normal serum 1,25(OH)2D.
Data suggest that control of CYP24A1 increase during diabetes has a beneficial effect on senescence induction and caspase-3 (show CASP3 Antibodies) increased expression.
the mechanism through which 1,25(OH)(2)D(3) induces the CYP24A1 enzyme
The expression of vitamin D 24-hydroxylase gene was directly regulated by serum calcium rather than 25-hydroxyvitamin D 1 alpha-hydroxylase.
Results show that Inhibition of 24-OHase activity modulates serum calcitriol PK in normal C3H/HeJ mice.
Cyp24a1 deficiency delays fracture repair and strongly suggest that vitamin D metabolites hydroxylated at position 24, such as 24,25(OH)2D3, play an important role in the mechanisms leading to normal fracture hea (show TTC7A Antibodies)
1,25(OH)2D is the preferred substrate for CYP24 in murine kidney mitochondria.
findings demonstrate that regulation of both the 25-hydroxyvitamin D-1 alpha-hydroxylase and 25-hydroxyvitamin D-24-hydroxylase genes by phosphorus is disordered in hypophosphatemic mice at the level of renal mRNA expression
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
1,25-@dihydroxyvitamin D3 24-hydroxylase
, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
, cytochrome P450 24A1
, cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
, cytochrome P450-CC24
, exo-mitochondrial protein
, vitamin D 24-hydroxylase
, vitamin D(3) 24-hydroxylase
, 25-hydroxyvitamin D-24-hydroxylase
, cytochrome P450, 24
, cytochrome P450, 24a1
, 25-hydroxyvitamin D3 24-hydroxylase
, Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase)
, cytochrome P450, subfamily 24
, 25-hydroxyvitamin D3-24-hydroxylase