Browse our MTHFD1 Proteins (MTHFD1)

Full name:: Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase Proteins (MTHFD1)

On www.antibodies-online.com are 6 Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) Proteins from 3 different suppliers available. Additionally we are shipping MTHFD1 Antibodies (45) and MTHFD1 Kits (3) and many more products for this protein. A total of 64 MTHFD1 products are currently listed.

Synonyms:: cb325, Dcs, E430024A07Rik, fc29f07, GB13160, MTHFC, Mthfd, mthfd1, Tb07.27M11.970, wu:fc29f07, zgc:55597

list all proteins	Gene Name	GeneID	UniProt
	MTHFD1	4522	P11586
Rat MTHFD1	MTHFD1	64300	P27653
	MTHFD1	108156	Q922D8
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MTHFD1 Proteins (MTHFD1) by Origin

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Relevant Pathways for MTHFD1 Proteins

Methionine Biosynthetic Process

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More Proteins for MTHFD1 Interaction Partners

Human Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) interaction partners

2 common and functional MTHFD1 polymorphisms (rs2236225 and rs1076991) modulate the risk associations of plasma serine and glycine with acute myocardial infarction in patients with stable angina pectoris.
MTHFD1 1958AA genotype is linked to a significantly reduced cancer risk. The 1958GG genotype is associated to PBMCs DNA hypomethylation as compared to the A allele carriership that may exert a protective effect for cancer risk by preserving from DNA hypomethylation
Results propose that MTHFD1 synthetase deficiency does not contribute to tumor initiation in the normal colon, but it limits tumor growth by reducing purine pools and altering expression of genes involved in cell proliferation and inflammation.
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris.
Paternal, rather than a maternal, transmission bias of MTHFD1 G1958A variant for neural tube defects susceptibility in the offspring.
impairments in MTHFD1 activity compromise both homocysteine remethylation and de novo thymidylate biosynthesis, and provide evidence that MTHFD1-associated disruptions in de novo thymidylate biosynthesis lead to genome instability that may underlie folate-associated immunodeficiency and birth defects
G1958A (MTHFD1) polymorphisms showed no association with ischemic heart disease in patients from Yucatan, Mexico
polymorphism of SNP loci rs1956545 and rs56811449 as well as a haplotype in MTHFD1 gene could have a role in the occurrence of neural tube defects in the Chinese population
MTHFD1 1958G > A is significantly associated with the susceptibility of neural tube defects in a Chinese population.
Data suggest impaired folate metabolism down-regulates placenta trophoblast proliferation, viability, invasive capacity, and progesterone secretion; silencing MTHFD1 gene down-regulates cell proliferation but does not alter progesterone secretion.

Mouse (Murine) Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) interaction partners

Study evaluated cognitive function in Mthfd1(gt/+) male and female mice using a behavioral battery composed of eight different tests, found that these mice display impaired cue-conditioned learning, while other behaviors remain intact.
Study observed decreased tumor growth in mice with reduced MTHFD1-synthetase activity, a model for the decreased metabolic activity of the human R653Q variant. These results propose that synthetase deficiency does not contribute to tumor initiation in the normal colon, but it limits tumor growth by reducing purine pools and altering expression of genes involved in cell proliferation and inflammation.
Moderately higher folate intake and MTHFD1-synthetase deficiency in pregnant mice result in a lower methylation potential in maternal liver and embryos and a greater incidence of defects in embryos.
Deficiency of the MTHFD1 10-formyltetrahydrofolate synthetase activity in embryos is associated with increased incidence of congenital heart defects
methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), an enzyme that generates methylenetetrahydrofolate from formate, ATP, and NADPH (show FDXR Proteins), functions in the nucleus to support de novo thymidylate biosynthesis.
Mthfd1gt/+ mice exhibited attentional dysfunction and a blunted affective response to committing an error. They also showed decreased expression levels for genes encoding choline dehydrogenase and the alpha 7 nicotinic cholinergic receptor.
Data suggest that decreased MTHFD1 activity (here, insertional mutant heterozygotes) has greater impact on one-carbon metabolism compared with folate-deficient diet; no interaction was observed between MTHFD1 genotype and folate deficiency.
Data suggest that heterozygosity in a lethal Mthfd1 mutation impairs folate status in pregnant mice (i.e., impairs fetal growth) but does not significantly affect homocysteine metabolism (i.e., does not cause neural tube defects).
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
MTHFD1 has a role in production of monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria

Zebrafish Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1, Methenyltetrahydrofolate Cyclohydrolase, Formyltetrahydrofolate Synthetase (MTHFD1) interaction partners

Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (show ALDH1L1 Proteins)) involving CEBPalpha helps relieve embryonic oxidative stress induced (show SQSTM1 Proteins) by ethanol exposure.

MTHFD1 Protein Profile

Protein Summary

This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.

Alternative names and synonyms associated with MTHFD1

methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (MTHFD1)
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (Mthfd1)
C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053509509.20)
C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053511741.50)
C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053511517.60)
C-1-tetrahydrofolate synthase, cytoplasmic (Tc00.1047053508207.240)
C-1-tetrahydrofolate synthase, cytoplasmic (Tb927.7.1600)
putative C-1-tetrahydrofolate synthase, cytoplasmic (LINJ_26_0310)
putative C-1-tetrahydrofolate synthase,cytoplasmic (LBRM_26_0350)
putative C-1-tetrahydrofolate synthase,cytoplasmic (LMJF_26_0320)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like (mthfd1l)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase (Mthfd1)
C-1-tetrahydrofolate synthase, cytoplasmic (LOC550749)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b (mthfd1b)
c-1-tetrahydrofolate synthase, cytoplasmic (Tsp_00651)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase L homeolog (mthfd1.L)
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (mthfd1)
C-1-tetrahydrofolate synthase, cytoplasmic (LOC589933)
C-1-tetrahydrofolate synthase, cytoplasmic (LOC100634307)

cb325 protein
Dcs protein
E430024A07Rik protein
fc29f07 protein
GB13160 protein
MTHFC protein
Mthfd protein
mthfd1 protein
Tb07.27M11.970 protein
wu:fc29f07 protein
zgc:55597 protein

Protein level used designations for MTHFD1

5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase , C-1-tetrahydrofolate synthase, cytoplasmic , C1-THF synthase , cytoplasmic C-1-tetrahydrofolate synthase , C1-tetrahydrofolate synthase , methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase , methylenetetrahydrofolate dehydrogenase 1 , pugilist , methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase , c-1-tetrahydrofolate synthase, cytoplasmic , formyltetrahydrofolate synthetase , methenyltetrahydrofolate cyclohydrolase , mthfd1 protein , methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase , c-1-tetrahydrofolate synthase, cytoplasmic-like , LOW QUALITY PROTEIN: C-1-tetrahydrofolate synthase, cytoplasmic

GENE ID	SPECIES
4522	Homo sapiens
64300	Rattus norvegicus
3536457	Trypanosoma cruzi strain CL Brener
3536565	Trypanosoma cruzi strain CL Brener
3547458	Trypanosoma cruzi strain CL Brener
3550685	Trypanosoma cruzi strain CL Brener
3658374	Trypanosoma brucei brucei strain 927/4 GUTat10.1
5069747	Leishmania infantum JPCM5
5416387	Leishmania braziliensis MHOM/BR/75/M2904
5652762	Leishmania major strain Friedlin
100173036	Pongo abelii
100306829	Salmo salar
108156	Mus musculus
423508	Gallus gallus
534382	Bos taurus
550749	Apis mellifera
260441	Danio rerio
10903890	Trichinella spiralis
380266	Xenopus laevis
414382	Sus scrofa
452965	Pan troglodytes
480352	Canis lupus familiaris
493369	Xenopus (Silurana) tropicalis
589933	Strongylocentrotus purpuratus
707059	Macaca mulatta
100027684	Monodelphis domestica
100062154	Equus caballus
100467466	Ailuropoda melanoleuca
100634307	Amphimedon queenslandica
100734825	Cavia porcellus

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