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Human 5-Methyltetrahydrofolate-Homocysteine Methyltransferase (MTR) interaction partners

1. Genotypes of transcobalamin 2 (TCN2 (show TCN2 Antibodies)) rs1801198, methionine synthase (MTR) rs1805087, methionine synthase reductase (MTRR (show MTRR Antibodies)) rs1801394, and methylene tetrahydrofolate reductase (MTHFR (show MTHFR Antibodies)) rs1801133 were examined in 201 children with Autism Spectrum Disorder and 200 healthy controls from the Han Chinese population. Our results showed no association of all examined SNPs with childhood ASD (show ARSD Antibodies) and its severity.

2. Methylene tetrahydrofolate reductase (MTHFR (show MTHFR Antibodies)) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR (show MTRR Antibodies)) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1 (show SHMT1 Antibodies)) C1420T and TYMS (show TYMS Antibodies) 5'-UTR (show UTS2R Antibodies) 28 bp tandem repeat exhibited negative association with homocysteine.

3. GG homozygous and G alleles of methionine synthase A2756G polymorphism were not associated with risks of non-Hodgkin lymphoma (NHL (show RTEL1 Antibodies)), Hodgkin lymphoma (HL), the subtype of NHL (show RTEL1 Antibodies) including the diffuse large B-cell lymphoma and follicular lymphoma.

4. SNPs in folate pathway genes MTHFR (show MTHFR Antibodies)/ MTR/ACE (show ACE Antibodies) and hyperhomocysteinemia have roles in risk of coronary artery disease.

5. Data indicate that two noncoding 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) variants, rs28372871 and rs1131450 were independently associated with a significantly increased risk of prostate cancer (PCa (show FLVCR1 Antibodies)).

6. Based on the results, an MTRA2756G polymorphism which changes activity and stability of the methionine synthase associated with prostate cancer in men.

7. MTR CpG sites were hypermethylated in preterm placenta. Methylated CpG sites were negatively associated with maternal plasma vitamin B12 (show NDUFB3 Antibodies) levels.

8. tagSNPs in MTHFR (show MTHFR Antibodies), MTR, MTRR (show MTRR Antibodies), and TCN2 (show TCN2 Antibodies) were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP.

9. MTHFR (show MTHFR Antibodies) A1298C and MS A2756G polymorphisms may be unrelated to male infertility.

10. The evaluation of genetic association showed that, MTHFR (show MTHFR Antibodies) C6877T (OR: 8.89, 95% CI: 2.01-39.40) and MTR A2756G (OR: 1.48, 95% CI: 1.09-2.00) polymorphisms associated with higher risk of CVD.

Mouse (Murine) 5-Methyltetrahydrofolate-Homocysteine Methyltransferase (MTR) interaction partners

Cow (Bovine) 5-Methyltetrahydrofolate-Homocysteine Methyltransferase (MTR) interaction partners

1. These findings indicate that greater synthesis of phosphatidylcholine (show SGMS1 Antibodies) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.