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polarity-induced spatiotemporal control of Rok and Pkn (show PKN1 Proteins) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (show AMH Proteins)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (show TNC Proteins) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (show FHOD1 Proteins) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (show EGFR Proteins) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (show CD44 Proteins) interaction with p115RhoGEF (show ARHGEF1 Proteins) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (show PI3 Proteins)-kinase membrane localization, AKT (show AKT1 Proteins) signaling, and cytokine (M-CSF (show CSF1R Proteins)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (show ZYX Proteins)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB (show NFKB1 Proteins) pathways.
we define how ROCK/LIMK (show LIMK1 Proteins) pathway regulates mast cell development and functions
Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells.
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK (show SNRK Proteins) in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (show ROR2 Proteins), which influenced Ras Homology Family Member A (show CXCL14 Proteins) (RhoA (show RHOA Proteins)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2 (show DVL2 Proteins)).
Data indicate that oxidative stress in diabetes causes a decrease in miR (show MLXIP Proteins)-133a expression leading to an increase in RhoA (show RHOA Proteins)/Rho kinase (show ROCK2 Proteins) pathway and muscle contraction.
that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation
ANXA1 (show ANXA1 Proteins) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA Proteins)-ROCK signaling pathway
the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (show WNT3A Proteins), which induces GSK-3beta phosphorylation and beta-catenin (show CTNNB1 Proteins) accumulation through RhoA (show RHOA Proteins) and ROCK activation.
The migration of dermal endothelial cells undergoing epithelial-mesenchymal transition is dependent on both extracellular matrix degradation and invadosome formation associated with MMP-2 (show MMP2 Proteins) proteolytic activity and Rho/ROCK cytoskeleton contraction.
ROCK inhibitor Y-27632 cooperated with Myc (show MYC Proteins) to immortalize keratinocytes efficiently, indicating that apoptosis is a major barrier to Myc (show MYC Proteins)-induced immortalization of keratinocytes.
Combined EGFR (show EGFR Proteins) and ROCK inhibition effectively blocks proliferation of triple-negative breast cancer (TNBC) cells.
Inhibition of ROCK signaling restored polarity, decreased disorganization of F-actin, and led to reduction of proliferation of breast cancer cells.
Data show that ROCK1 is the direct target of miR (show MLXIP Proteins)-300, and that the 3' UTRs of ROCK1 had at least 7 nucleotides that were complementary to the miR (show MLXIP Proteins)-300 seed region.
ROCK activation phosphorylated Rac1b (show RAC3 Proteins) at Ser71 and increased reactive oxygen species (ROS (show ROS1 Proteins)) levels by facilitating the interaction between Rac1b (show RAC3 Proteins) and cytochrome c (show CYCS Proteins). Conversely, ROCK inactivation abolished their interaction, concomitant with ROS (show ROS1 Proteins) reduction.
OB-Rb (show LEPR Proteins), RhoA (show RHOA Proteins)/ROCK, PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins), JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathways and NF-kB activation are involved in leptin (show LEP Proteins)-induced upA (show PRAP1 Proteins) expression.
data suggests that ROCK1 may serve as a potential therapeutic target to enhance current treatment regimens for pancreatic cancer
Results indicate that ROCK1 and ROCK2 (show ROCK2 Proteins) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (show LIMK1 Proteins)/cofilin (show CFL1 Proteins) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (show MAPK14 Proteins) phosphorylation and MMP13 (show MMP13 Proteins) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (show RHOA Proteins)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (show DDX4 Proteins) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1