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Suggest a primary metabolic role for CES1 in the capacity of skin/keratinocytes to mediated biotransformation of penta-ethyl ester prodrug of DTPA.
These data suggest that infants younger than 3 weeks of age would exhibit significantly lower CES1- and CES2-dependent metabolic clearance compared with older individuals.
The intestinal transport of oseltamivir, a hCE1 (show RNGTT Antibodies) substrate, could be evaluated in subclone #78 cell monolayers.
An association was identified with a genetic variation in CES1 and early-onset capecitabine-related toxicity.
Reduced CES1 expression/activity could promote development of METH-PAH.
These data suggest that CES1 genetic variants and gender are important contributing factors to variability in dabigatran etexilate activation in humans.
some functional CES1 genetic variants (for example, G143E) may impair ACE (show ACE Antibodies) inhibitor activation, and consequently affect therapeutic outcomes of ACEI prodrugs.
HNF4alpha (show HNF4A Antibodies) regulated CES1 expression by directly binding to the proximal promoter of CES1.
We conclude that the -816A>C variant is not associated with interindividual variability in CES1 expression and activity or therapeutic response to ACEI prodrugs
Our study identified CYP2C19 (show CYP2C19 Antibodies)*3 and CES1 rs8192950 as genetic polymorphisms related to recurrent ischemic events in patients with extracranial or intracranial occlusive disease, demonstrating the important roles of CYP2C19 (show CYP2C19 Antibodies) and CES1 in patients treated with clopidogrel
One novel isoform termed alternative pig liver esterase (show ESD Antibodies) (APLE) was found to hydrolyze methyl-(2R,4E)-5-chloro-2-isopropyl-4-pentenoate in a highly stereoselective manner (E>200).
The objective of this study is to explore the mechanisms that regulate TGH expression in porcine adipocyte and its role in fasting-induced and Isoproterenol-stimulated lipolysis in porcine primary adipocytes.
PMPMEase was purified to apparent homogeneity from porcine liver supernatant.
Loss of CES1 is associated with the susceptibility to high cholesterol diet-induced liver injury.
Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin (show INS Antibodies) sensitivity.
Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.
Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR (show NR1H4 Antibodies)-controlled lipid homeostasis
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
, carboxyesterase ES-1
, retinyl ester hydrolase
, liver carboxylesterase 1
, neutral retinyl ester hydrolase
, Esterase 2 member of carboxylesterase-cluster 1
, esterase 2, member of carboxylesterase-cluster 1
, carboxylesterase 1
, carboxylesterase 1 (monocyte/macrophage serine esterase 1)
, acyl coenzyme A:cholesterol acyltransferase
, acyl-coenzyme A:cholesterol acyltransferase
, brain carboxylesterase hBr1
, carboxylesterase 2 (liver)
, cholesteryl ester hydrolase
, cocaine carboxylesterase
, human monocyte/macrophage serine esterase 1
, methylumbelliferyl-acetate deacetylase 1
, monocyte/macrophage serine esterase
, serine esterase 1
, triacylglycerol hydrolase
, carboxylesterase D1
, alternative pig liver esterase
, liver carboxylesterase
, prenylated methylated protein methyl esterase
, carboxylesterase 1-like
, carboxyesterase ES-3
, esterase 22
, liver carboxylesterase 3
, pI 5.5 esterase