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The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 Proteins), 2 and 3 in granulosa cells and PON1 (show PON1 Proteins) activity in follicular fluid and plasma of dairy cows.
In donor retina from patients with diabetes, all three PON1 (show PON1 Proteins), PON2 (show PON2 Proteins) and PON3 were expressed, and there was a significant increase in PON3 expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control
PON3 suppressed cell proliferation in vivo and in vitro, which was attributed to its cell-cycle arrest effect.
PON3 protein can be detected in plasma and resides in the high-density lipoprotein fraction and protects against Oxidative stress by hydrolyzing certain oxidized lipids in lipoproteins, macrophages and Atherosclerotic lesions.
Our study showed that although lipoic acid up-regulates PON3 but down-regulates PON1 (show PON1 Proteins) mRNA expression, it increases both PON1 (show PON1 Proteins) and PON3 protein levels and arylesterase activity in HepG2 cells. We can report that lipoic acid may be useful for preventing atherosclerosis at therapeutic doses.
Data suggest that paraoxonases (PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), PON3) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 (show PON1 Proteins) activities are associated with poor survival in patients with severe sepsis. [REVIEW]
Data show that the mRNA levels of both paraoxonases PON2 (show PON2 Proteins) and PON3 were significantly upregulated whereas PON1 (show PON1 Proteins)'s mRNA was absent in transgenic mouse hearts.
Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4 (show ARHGEF4 Proteins), PON3, STAT5a (show STAT5A Proteins), and VAX2 (show VAX2 Proteins) gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation (show HELLS Proteins) analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor
Low PON3 expression is associated with hepatocellular carcinoma progression.
This study showed that the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway is up-regulated by the expression of PON3 in oral squamous cell carcinoma by AP-1 (show FOSB Proteins).
Studies indicate that three paraoxonases PON1 (show PON1 Proteins), PON2 (show PON2 Proteins), and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.
study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled
PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1 (show PON1 Proteins)/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.
The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.
Results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese gilts compared with the leaner (show CACNA1A Proteins) gilts.
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described\; however, only one has been fully characterized.
, serum paraoxonase/lactonase 3-like
, serum paraoxonase/lactonase 3