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Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia
ARHGEF7, a guanine nucleotide exchange factor for Rho GTPases, as one novel TIP-1-interacting protein in human glioblastoma cells
this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1.
The study provided the first evidence showing that TIP-1 modulates p53 protein stability and is involved in the radioresistance of malignant gliomas.
The study reports the identification of 18 new glutaminase-interacting protein - binding peptides with novel internal motifs that map to a number of candidate human glutaminase-interacting protein partner proteins.
this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers.
HPV16 E6, Tip-1 and ARHGEF16 may cooperate to activate Cdc42 and support a potential link between the expression of HPV16 E6 and Cdc42 activation.
This is the first study reporting BAI2 as an interaction partner of GIP.
TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway
HPV16 E6 protein may increase cell motility by augmenting GTP RhoA mediated activation of RhoA kinases and that this is dependent on the expression of the Tip-1 protein
TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand.
the overexpression, efficient refolding, single-step purification, and biophysical characterization of recombinant human TIP-1 with three different C-terminal target protein recognition sequence motifs by CD, fluorescence, and NMR methods
TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3.
observations indicate a role for TIP-1 in gastrulation movements and in filopodia growth induction
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Tax interaction protein 1
, glutaminase-interacting protein 3
, tax-interacting protein 1
, tax1-binding protein 3
, Tax1 (human T-cell leukemia virus type I) binding protein 3
, Tax1 binding protein 3
, tax interaction protein 1