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Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia
ARHGEF7 (show ARHGEF7 Proteins), a guanine nucleotide exchange factor (show RASGRF1 Proteins) for Rho GTPases, as one novel TIP-1-interacting protein in human glioblastoma cells
this study reports the identification of two new hGIP-interacting partners, DTX1 (show DTX1 Proteins) and STAU1 (show STAU1 Proteins).
The study provided the first evidence showing that TIP-1 modulates p53 (show TP53 Proteins) protein stability and is involved in the radioresistance of malignant gliomas.
The study reports the identification of 18 new glutaminase (show GLS Proteins)-interacting protein - binding peptides with novel internal motifs that map to a number of candidate human glutaminase (show GLS Proteins)-interacting protein partner proteins.
this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers.
HPV16 E6, Tip-1 and ARHGEF16 (show ARHGEF16 Proteins) may cooperate to activate Cdc42 (show CDC42 Proteins) and support a potential link between the expression of HPV16 E6 and Cdc42 (show CDC42 Proteins) activation.
This is the first study reporting BAI2 (show BAI2 Proteins) as an interaction partner of GIP (show GIP Proteins).
TIP-1 may represent a novel regulatory element in the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway
HPV16 E6 protein may increase cell motility by augmenting GTP (show AK3 Proteins) RhoA (show RHOA Proteins) mediated activation of RhoA (show RHOA Proteins) kinases and that this is dependent on the expression of the Tip-1 protein
observations indicate a role for TIP-1 in gastrulation movements and in filopodia growth induction
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Tax interaction protein 1
, glutaminase-interacting protein 3
, tax-interacting protein 1
, tax1-binding protein 3
, Tax1 (human T-cell leukemia virus type I) binding protein 3
, Tax1 binding protein 3
, tax interaction protein 1