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Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor (show CHRM3 Proteins) signaling.
PhLP1 binding stabilizes the Gbeta (show SUCLG2 Proteins) fold, disrupting interactions with CCT (show FLVCR2 Proteins) and releasing a PhLP1-Gbeta (show SUCLG2 Proteins) dimer for assembly with Ggamma.
During corticogenesis, a cilium-transduced, noncanonical IGF-1R (show IGF1R Proteins)-Gbetagamma-phospho(T94)Tctex-1 (show DYNLT1 Proteins) signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
WDR26 (show WDR26 Proteins) is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
Gbetagamma subunits enter in a protein complex with activated Rap1a (show RAP1A Proteins) and its effector Radil (show Radil Proteins); this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness.
G protein betagamma subunits stimulate type V and VI adenylyl cyclases
Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF (show HBEGF Proteins), which sequentially activates EGFR (show EGFR Proteins) and p38 (show CRK Proteins)
ectopically expressed cTalpha (show PCYT1A Proteins) 1) forms a heterotrimeric complex with rod Gbeta (show SUCLG2 Proteins)(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin (show RHO Proteins) or S-cone opsin (show RHO Proteins)
Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o (show GNAO1 Proteins)) upon activation of mGluR6 (show GRM6 Proteins) closes the TRPM1 (show TRPM1 Proteins) channel, perhaps via a direct interaction.
findings demonstrate that transducin (show GNAT1 Proteins) betagamma-complex controls signal amplification of the rod phototransduction cascade and is critical for the ability of rod photoreceptors to function in low light conditions.
The PIP2-induced orientation of the GRK2 (show ADRBK1 Proteins)-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 (show ADRBK1 Proteins) PH domain.
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
guanine nucleotide-binding protein G(T) subunit gamma-T1
, transducin gamma chain
, guanine nucleotide binding protein (G protein), gamma 1 subunit
, gngt1 gene for guanine nucleotide binding protein (G protein) gamma 1 subunit
, rod transducin
, guanine nucleotide binding protein, gamma transducing activity polypeptide 1