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Human Monoclonal IGFBPI Primary Antibody for ELISA, WB - ABIN259029
Logan, Ponnampalam, Rahnama, Lobie, Mitchell: The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. in Human reproduction (Oxford, England) 2010
Human Polyclonal IGFBPI Primary Antibody for IHC, IHC (p) - ABIN4321641
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1
The insulin-like growth factor binding protein 1 (29-31kDa)is similarities to mammalian.
HIF-1 mediates hypoxia-induced IGFBP-1 gene expression in early development by selectively interacting with the hypoxia response elements and its adjacent HIF-1 ancillary sequence.
TGE duplicated IGFBP-1 may provide additional flexibility in fine-tuning insulin-like growth factor signaling activities under hypoxia and other catabolic conditions.
IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey.
Studied levels of insulin like growth factor binding protein 1 (ICFBP-1) in type 2 diabetes mellitus patients before and after gastric bypass surgery. Found increased serum level of ICFBP-1 6 months after gastric bypass compared with overweight/ healthy weight controls.
These data links for the first time, increased decidual IGFBP-1 phosphorylation at discrete sites with human Intrauterine Growth Restriction.
The maternal IGFBP-1 level during the first trimester is a significant independent factor for small for gestational age and large for gestational age neonates and may be an independent biomarker for fetal growth.
Results showed that high IGFBP1 expression was significantly correlated with haematogenous metastasis and poor survival in patients with gastric cancer who underwent gastrectomy.
phIGFBP-1 test alone or in combination with CL has a low predictive accuracy to predict PTB in symptomatic women.
TXNDC5 contributes to abnormal rheumatoid arthritis synovial fibroblast-like cells proliferation, migration and IL-6 production by inhibiting IGFBP1 expression.
The relationship between copeptin and IGFBP-1 observed in the acute phase of an MI is sustained over time in type 2 diabetics.
Genetic variation in growth factor pathway genes INHA and IGFBP1/3 may predict longitudinal mammographic density change after women quit estrogen and progestin combined therapy .
These results indicate that the region -4701 to -7501 bp upstream of IGFBP-1 functions as an enhancer for IGFBP-1 expression in ESCs undergoing decidualization, that C/EBPbeta and FOXO1 bind to the enhancer region to up-regulate IGFBP-1 expression, and that C/EBPbeta induces H3K27ac by recruiting p300 to the IGFBP-1 enhancer.
In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events.
Study shows that the 3'-untranslated region of IGFBP1 mRNA is targeted by miR-542-3p. The results suggest that miR-542-3p plays an important role in endometrial decidualization by regulating the expression of major decidual marker genes.
association between serum IGFBP-1 and IGF-I levels with advanced fibrosis in non-alcoholic fatty liver disease patients
we demonstrated that IGFBP-1 suppress the migration of BGC-823 gastric cancer cells and play a protective role in the process of H. pylori-induced gastric cancer.
hIGFBP1 affects endothelial cell responses and acceleration of endothelial regeneration in transgenic mouse model.
Vaginal PAMG-1 in patients with a cervical length of 15-30 mm is highly predictive of imminent spontaneous preterm delivery.
These data support the hypothesis that down regulation of the insulin-like growth factor (IGF-I) signaling links decidual phosphorylated insulin-like growth factor-binding protein (IGFBP-1) hyperphosphorylation to restricted fetal growth in placental insufficiency.
There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors
A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and KLK1 could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL) and insulin-like growth factor binding protein-1 (IGFBP-1) expression and transformation in vitro.
We report interactions between CSNK-2beta and IGFBP-1 as well as mTOR and CSNK-2beta, providing strong evidence of a mechanistic link between mTOR and IGF-I signaling, two critical regulators of cell growth via CSNK-2.
In inflamed experimental autoimmune encephalomyelitis (EAE) spinal cord, study found a significant increased number of IGF-I expressing neurons versus a reduced number of IGFBP-1 positive neurons. Moreover, while nearly all IGF-I neurons expressed GSK3beta, some expressed it more intensely.
the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss
Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha).
serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans
During the two week starvation period, both the levels of plasma IGF-1 and IGFBP-1 decreased.
These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels.
Global deletion of Igfbp1 in a c-Myc transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass.
IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals
IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways.
Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR.
high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model
the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors
IGFBP-1 may have an important regulatory role in vivo and in the pathogenesis of type 2 diabetes, in which loss of insulin release is an early pathogenetic event
When IGFBP1 is in a complex with BAK, formation of a proapoptotic p53/BAK complex and apoptosis induction are impaired, both in cultured cells and in liver.
These data suggest that membrane dlk1 variants bind to extracellular IGFBP1/IGF-1 complexes, which may favor the release of IGF-1 and increase the local concentration of free IGF-1 that can enhance IGF receptor signaling, leading to adipogenesis.
Ahr regulates Igfbp-1 and Lpl expression in the liver. TCDD treatment did not increase the Igfbp-1 and Lpl mRNA levels in Ahr knockout mice.
the embryopathic effects are associated with knockdown of EGNL1 and the associated induction of Igfbp1 mRNA in the placenta, but not the embryo.
Allantoic fluid levels of IGFBP-1 were increased in nuclear transfer pregnancies
IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm
Results of fluorescence in situ and radiation hybrid (RH) mapping assigned this gene to porcine chromosome (SSC) 18q24-qter.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
insulin-like growth factor binding protein 1
, insulin-like growth factor binding protein-1
, IGF-binding protein 1
, alpha-pregnancy-associated endometrial globulin
, amniotic fluid binding protein
, binding protein-25
, binding protein-26
, binding protein-28
, growth hormone independent-binding protein
, insulin-like growth factor-binding protein 1
, placental protein 12
, INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1)