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Human Polyclonal PA2G4 Primary Antibody for FACS, IHC (p) - ABIN1882075
Zhang, Linn, Liu, Melamed, Tavora, Young, Burger, Hamburger: EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. in Molecular cancer therapeutics 2008
In this study, the authors demonstrated that overexpression of ErbB3-binding protein 1 (EBP1) promoted not only a reduction of wild type of p85 subunit of phosphoinositide 3-kinase but also oncogenic mutant forms of p85 which were identified in human cancers.
The results demonstrate an important role of Ebp1 (show NFKB1 Antibodies) in promoting cell proliferation in Acute Myelogenous Leukemic Cells through the regulation of both rRNA synthesis and Proliferating Cell Nuclear Antigen (show PCNA Antibodies) expression.
results show that EBP1 (show NFKB1 Antibodies) interacts directly with PPIns and associate with PtdIns(3,4,5)P3 in the nucleolus.
The adapter function of EBP1 (show NFKB1 Antibodies) P42 (show EPB42 Antibodies) stabilized the interaction of FBXW7 (show FBXW7 Antibodies) with its substrates and promoted FBXW7 (show FBXW7 Antibodies)-mediated degradation of oncogenic targets, enhancing its overall tumor-suppressing function. Results establish distinct physical and functional interactions between FBXW7 (show FBXW7 Antibodies) and EBP1 (show NFKB1 Antibodies) isoforms, which yield their mechanistically unique isoform-specific functions of EBP1 (show NFKB1 Antibodies) in cancer.
The combined determination of Ebp1 (show NFKB1 Antibodies) and p53 (show TP53 Antibodies) expression levels in cervical cancer patients could support the effective prediction of metastatic potential and patient prognosis.
Data highlight the tissue specificity function of EBP1 (show NFKB1 Antibodies) isoforms and show that only the oncogene (show RAB1A Antibodies) p48 (show IRF9 Antibodies) activates MHC II expression in human solid tumors, via STAT1 (show STAT1 Antibodies) phosphorylation, in order to affect tumor progression by triggering specific immune response.
Our results suggest a novel function of Ebp1 (show NFKB1 Antibodies) as a binding protein and negative regulator of Anxa2 (show ANXA2 Antibodies). The functional association between Anxa2 (show ANXA2 Antibodies) and EBP1 (show NFKB1 Antibodies) may participate in regulating cancer cell proliferation and invasion, contributing to cancer progression.
Ebp1 (show NFKB1 Antibodies) functionality is independent from heat-shock-protein-regulated progression networks in prostate cancer.
EBP1 (show NFKB1 Antibodies) participates in the regulation of intestinal inflammation via mediating Akt (show AKT1 Antibodies) signaling pathway.
Data suggest that inhibiting ErbB3-binding protein 1 Ebp1 phosphorylation may be an effective mechanism for inhibiting T-cell activation and proliferation.
these findings establish an interaction between Pa2G4 and Six1 (show SIX1 Antibodies), and demonstrate that it has an important role in the development of tissues affected in Branchiootorenal Spectrum disorder.
These results strongly suggest that PA2G4 may have an important role on the regulation of DNA replication in eukaryotic cells.
Ebp1 (show NFKB1 Antibodies) p42 (show EPB42 Antibodies) isoform regulates the proteasomal degradation of the p85 (show ECM1 Antibodies) regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70 (show HSP70 Antibodies)/CHIP.
EBP1 (show NFKB1 Antibodies) is a novel component of the ZFP809-TRIM28 (show TRIM28 Antibodies) silencing complex to restrict the moloney murine leukemia virus replication in embryonic cells.
Ebp1 (show NFKB1 Antibodies) has a role in the regulation of embryonic muscle progenitors and adult muscle stem cells, which likely operates independently of ErbB3 (show ERBB3 Antibodies) signaling
EBP1 (show NFKB1 Antibodies) is in the cytoplasm & nucleolus. Nucleolar localization requires AA sequences at the NH2- and COOH-ends. Overexpression inhibits proliferation of human fibroblasts. It is part of RNP (show RNPC3 Antibodies) complexes & associates with different rRNAs.
IGF-1 (show IGF1 Antibodies) production and IGBP-3 and 4 protein levels were reduced in both embryo fibroblasts and adult knock-out mice. The proliferation of fibroblasts derived from Day 12.5 knock out embryos was also decreased as compared to that of wild type cells.
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.
ErbB-3 binding protein 1
, ErbB3-binding protein Ebp1
, cell cycle protein p38-2G4 homolog
, erbB3-binding protein 1
, proliferation-associated protein 2G4
, ErbB3-binding protein 1
, proliferation-associated 2G4, 38kDa
, proliferation-associated protein 2G4-like
, similar to proliferation-associated 2G4, 38kD
, IRES-specific cellular trans-acting factor 45 kDa
, proliferation-associated 2G4, 38kD
, proliferation-associated protein 1
, protein p38-2G4