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Mouse (Murine) Receptor (G Protein-Coupled) Activity Modifying Protein 3 (RAMP3) interaction partners

1. the cardiovascular response of Ramp1 (show RAMP1 Antibodies)(-/-), Ramp2 (show RAMP2 Antibodies)(+/-), Ramp3(-/-), Ramp1 (show RAMP1 Antibodies)(-/-)/Ramp3(-/-) double-knockout (dKO), and Calcrl (show CALCRL Antibodies)(+/-) mice to AM and CGRP (show CALCA Antibodies) were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR (show CALCR Antibodies)/RAMP1 (show RAMP1 Antibodies) heterodimer, but that AM signaling via CLR (show CALCR Antibodies)/RAMP2 (show RAMP2 Antibodies) and CLR (show CALCR Antibodies)/RAMP3 also contributes to some hypotensive action.

2. RAMP3 regulates drainage through lymphatic vessels.

3. G-protein-coupled receptor 30 (show GPER Antibodies) interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection.

4. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD (show ADM2 Antibodies)), calcitonin receptor-like receptor (CRLR (show CALCRL Antibodies)), and RAMP1 (show RAMP1 Antibodies) and RAMP2 (show RAMP2 Antibodies).

5. these data demonstrate a sex-dependant, cardioprotective role of RAMP3 in the setting of chronic hypertension.

6. role in cell surface expression of CRLR (show CALCRL Antibodies)/RAMP heterodimeric receptors

7. RAMP2 (show RAMP2 Antibodies) and RAMP3 have distinct physiological functions throughout embryogenesis, adulthood, and old age

8. tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation (show HELLS Antibodies) profile throughout the Ramp3-WAP-Tbrg4 (show TBRG4 Antibodies) locus.

Human Receptor (G Protein-Coupled) Activity Modifying Protein 3 (RAMP3) interaction partners

1. interaction of RAMP2 (show RAMP2 Antibodies) or RAMP3 with CLR (show DCLK3 Antibodies) induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism.

2. the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR (show DCLK3 Antibodies) and RAMP2 (show RAMP2 Antibodies), but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus

3. Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor (show CALCRL Antibodies)) N-terminal domain; RAMP3/RAMP2 (show RAMP2 Antibodies)/RAMP1 (show RAMP1 Antibodies) appear to alter accessibility of specific residues at CALCRL (show CALCRL Antibodies)-RAMP interface.

4. The expression of RAMP3 is downregulated in the fetal lung with increasing gestational age.

5. the RAMP3 TMD (show TTN Antibodies) participates in the negative regulation of CLR (show DCLK3 Antibodies)/RAMP3 internalization.

6. Data show that LOXL2 (show LOXL2 Antibodies) and RAMP3 are strongly coexpressed in human colon, breast, and gastric carcinomas but not in normal colon or gastric epithelial cells.

7. This study provides insight into the role of three amino acid changes in human RAMP3.

8. Morphological fluorescence techniques, bioluminescence resonance energy transfer, and bimolecular fluorescence complementation analysis demonstrate that the secretin receptor (show SCTR Antibodies) associates specifically with RAMP3, but not with RAMP1 (show RAMP1 Antibodies) or RAMP2 (show RAMP2 Antibodies).

9. Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR (show CALCRL Antibodies)) in HEK (show EPHA3 Antibodies)-293 cells

10. results show the presence of calcitonin receptor-like receptor (show CALCRL Antibodies) and receptor activity-modifying proteins in middle meningeal, middle cerebral, pial, and superficial temporal vessels

Cow (Bovine) Receptor (G Protein-Coupled) Activity Modifying Protein 3 (RAMP3) interaction partners

1. Data indicate that adrenomedullin (show ADM Antibodies) mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR (show CALCRL Antibodies), RAMP2 (show RAMP2 Antibodies) and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells.