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show that PIM1 (show PIM1 Proteins) contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 (show PIM2 Proteins) and PIM3 could also influence the outcome.
These results demonstrate the involvement of PIM (show PIM1 Proteins) kinases in LIF (show LIF Proteins)-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.
PIM (show PIM1 Proteins) kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival.
Our study suggests that up-regulation of Pim-3 successfully accelerated Chronic Obstructive Pulmonary Disease development, and aggravated lung damage
High PIM3 expression is associated with osteosarcoma.
The expression status of Pim-3 mRNA was significantly associated with pathological parameters such as pre-surgery prostate specific antigen, Gleason score, pathological stage, and lymphoid metastasis.
Pim-3 expression was inversely correlated with that of miR (show MLXIP Proteins)-377.
SSRP1 (show SSRP1 Proteins)/Ets-1 (show ETS1 Proteins)/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel.
Pim-3 expression showed a positive correlation with tumor cell differentiation.
Pim-3 has a role in human pancreatic cancer cell survival against radiation
Loss of PIM3 is associated with abnormal hematopoietic phenotypes.
investigation of physiological role of Pim3 in beta-cell function: regulates glucose-stimulated insulin (show INS Proteins) secretion; limits ERK (show EPHB2 Proteins) signaling; interacts with SOCS6 (show SOCS6 Proteins); Pim3 localized to beta-cell; Pim3 knockout mice display increased glucose tolerance
Pim-3 has an important role in modulating c-Myc and PGC-1alpha protein levels and cell growth
All three Pim (show PIM1 Proteins) kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK (show EPHA3 Proteins)-293 cells
Pim-3 kinase has a novel role in the control of self-renewal of embryonic stem cells.
Pim-3 is expressed in endothelial cells and promotes vascular tube formation.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis.
serine/threonine protein kinase pim-3
, non-specific serine/threonine protein kinase
, serine/threonine-protein kinase pim-3
, serine/threonine kinase Pim-3
, kinase induced by depolarization
, protein kinase Kid-1
, proviral integration site 3
, serine threonine kinase pim3
, KID-1/kinase induced by depolarization