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TAF9B also regulates neuronal gene transcription in vivo.
These observations suggest that although CINAP deletion in mice does not influence learning and memory behaviors, CINAP is required for restriction of locomotor and exploratory activities.
RNA interference experiments suggest that TAF9L is essential for HeLa cell growth and this protein is involved in transcriptional repression.
TAF9b (TAF9L) was identified as a subunit of TFIID.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process.
TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor
, transcription initiation factor TFIID subunit 9B
, transcription-associated factor TAFII31L
, TAF9-like RNA polymerase II TATA box binding protein (TBP)-associated factor 31 kD
, TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kD
, TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
, neuronal cell death-related gene in neuron 7
, neuronal cell death-related gene in neuron-7
, TBP-associated factor 9L
, neuronal cell death-related protein 7
, transcription associated factor TAFII31L
, transcription initiation factor IID, 31kD subunit