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TRIM32 as a crucial positive regulator of Herpes Simplex Virus type 1 (HSV-1) induced IFN-beta (show IFNB1 Proteins) production in corneal epithelial cells, and it played a predominant role in clearing HSV-1 from the cornea.
HSP70 (show HSP70 Proteins)-TRIM32 complex is biochemically distinct from the previously characterized 14-3-3 (show YWHAQ Proteins)-TRIM32 phospho-complex.
Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor)
Duchenne muscular dystrophy (show DMD Proteins) muscles showed a selective up-regulation of the ubiquitin ligase tripartite motif-containing protein 32 (TRIM32). The induction of TRIM32 was due to a transcriptional effect and it correlated with disease severity.
we provide a detailed characterization of the TRIM (show TRAT1 Proteins) ligases TRIM25 (show TRIM25 Proteins) and TRIM32 and show how their oligomeric state is linked to catalytic activity
that TRIM32 plays a protective role in aortic banding-induced pathological cardiac remodelling by blocking Akt (show AKT1 Proteins)-dependent signalling
these findings suggest that TRIM32 might play important roles in the hepatocarcinogenesis.
results show a novel molecular cascade involving miR (show MLXIP Proteins)-155 and TRIM32 leading to HIV-1 Tat (show TAT Proteins)-induced attenuated proliferation of neural precursor cells; study also uncovered an unidentified role for miR (show MLXIP Proteins)-155 in modulating human neural stem cell proliferation, helping in better understanding of neural precursor cells and diseased brain
Studies indicate most-studied TRIpartite Motif (TRIM (show TRAT1 Proteins))-NHL proteins TRIM2 (show TRIM2 Proteins), TRIM3 (show TRIM3 Proteins), TRIM32 and TRIM71 (show TRIM71 Proteins), and their mutations have been linked to diseases.
Results suggest that Salmonella effector SseK3 binding to host tripartite motif-containing 32 protein (TRIM32) in the inhibition of nuclear factor kappa B (NF-kappaB (show NFKB1 Proteins)) activation: [SseK3]
suppression of Trim32 promotes the recovery of neurological function after traumatic brain injury.
the presented data link the Parkinson's disease-associated gene alpha-synuclein to the neuronal cell fate determinant TRIM32.
TRIM32 is a novel essential positive factor modulating axonal regeneration and the recovery of motor function following SCI, possibly through suppressing proliferation of glial cells.
TRIM32 protein expression is defective in atopic dermatitis lesional skin.
In summary, the data presented here reveal that TRIM32 directly regulates at least two of the four Yamanaka Factors (cMyc (show MYC Proteins) and Oct4 (show POU5F1 Proteins)), to modulate cell fate transitions.
TRIM32 represents a model of intrinsic immunity, in which a host protein directly senses and counters viral infection in a species specific fashion by directly limiting viral replication
NDRG2 (show NDRG2 Proteins) accumulated in skeletal muscle and myoblasts in the absence of TRIM32. NDRG2 (show NDRG2 Proteins) overexpression in myoblasts led to reduced cell proliferation and delayed cell cycle withdrawal during differentiation.
TRIM32 overexpression promotes cell oncogenic transformation and tumorigenesis in mice in a largely p53 (show TP53 Proteins)-dependent manner.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
E3 ubiquitin-protein ligase TRIM32
, tripartite motif-containing 32
, TAT-interactive protein, 72-KD
, tripartite motif containing 32
, 72 kDa Tat-interacting protein
, tripartite motif-containing protein 32
, zinc finger protein HT2A
, zinc-finger protein HT2A
, bM468K2.2 (tripartite motif protein 32)
, tripartite motif protein 32
, zinc finger protein 117