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These results demonstrate, for the first time, the role for USP47, as a novel target of Sox9, in the regulation of epithelial-mesenchymal transition and metastasis of colorectal cancer cells.
these data reveal a new post-transcriptional role for USP47 and USP7 in inflammation by regulating inflammasome activation and the release of the pro-inflammatory cytokines IL-1beta and IL-18, and implicate dual USP7 and USP47 inhibitors as potential therapeutic agents for inflammatory disease.
these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity.
miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A.
USP47 is a deubiquitinase that prevents beta-catenin ubiquitination.
Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47.
The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation.
USP47 has a role in regulating DNA repair and maintaining genome integrity
USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies.
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (polb), stabilizing polb thereby playing a role in base-excision repair (BER) (By similarity).
ubiquitin specific protease 47
, ubiquitin specific peptidase 47
, Deubiquitinating enzyme 47
, Ubiquitin thiolesterase 47
, Ubiquitin-specific-processing protease 47
, ubiquitin carboxyl-terminal hydrolase 47
, ubiquitin thioesterase 47
, ubiquitin carboxyl-terminal hydrolase 47-like
, Ubiquitin carboxyl-terminal hydrolase 47-like
, Trf (TATA binding protein-related factor)-proximal homolog
, deubiquitinating enzyme 47
, ubiquitin thiolesterase 47
, ubiquitin-specific-processing protease 47