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These results show that b-arrestin1 (show SAG Antibodies) and b-arrestin2 exert differential actions on PAC1R internalization and PAC1R-dependent ERK1/2 activation, and suggest that the two b-arrestin (show SAG Antibodies) isoforms may be involved in fine and precise tuning of the PAC1R signaling pathways.
These results provide evidence for an association between ADCYAP1R1 and PTSD and indicate that there may indeed be sex differences.
These findings lead to a model in which E2 induces the expression of ADCYAP1R1 through binding of ERalpha (show ESR1 Antibodies) at the ERE as an adaptive response to stress. Inhibition of E2/ERalpha (show ESR1 Antibodies) binding to the ERE containing the rs2267735 risk allele results in reduced expression of ADCYAP1R1, diminishing estrogen regulation as an adaptive stress response and increasing risk for PTSD.
Data suggest that GCGR (glucagon receptor (show GCGR Antibodies)) activation proceeds via a mechanism in which transmembrane helix 6 (TM6) is held in an inactive conformation by a conserved polar core and a hydrophobic lock (involving intracellular loop 3, IC3); mutations in the corresponding polar core of GCGR (show GCGR Antibodies) or PAC1R disrupt these inhibitory elements, allow TM6 to swing outward, and induce constitutive G protein signaling.
Results confirmed for the first time that doxycycline specially targeted pituitary adenylate cyclase-activating polypeptide (PACAP (show ADCYAP1 Antibodies)) receptor type 1 (PAC1) imitating PACAP (show ADCYAP1 Antibodies)(30-37) and acted as an enhancer by facilitating the subsequent ligand binding and the activation of PAC1.
Data show that glucocorticoid response genes NR3C1 (show NR3C1 Antibodies), ADCYAP1R1 and HSD11B2 (show HSD11B2 Antibodies) were relatively hypomethylated whereas FKBP5 (show FKBP5 Antibodies) was hypermethylated.
High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced bronchodilator response in children with asthma.
and its receptor (PAC1) are involved in stress response and anxiety.
PAC1/PACAP (show ADCYAP1 Antibodies) receptor endocytosis contributes to ERK (show EPHB2 Antibodies) acktivation.
Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in posttraumatic stress disorder and other anxiety disorders.
PACAP (show ADCYAP1 Antibodies)/PAC1 signaling is important for light regulated behavior, VIP (show Vip Antibodies)/VPAC2 (show VIPR2 Antibodies) signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality.
The results suggested that sympathetic nerve innervation may be responsible for Pituitary adenylate cyclase-activating polypeptide (show ADCYAP1 Antibodies)-regulated hematopoiesis in bone marrow, mainly via PAC1.
PACAP (show ADCYAP1 Antibodies)/PAC1 signaling has a role in light regulated food anticipatory activity
PAC1 plays a prominent role in chronic restraint stress response, but less so in the acute restraint stress response.
overexpression of Pac1 rescued the Zac1 (show PLAGL1 Antibodies) knockdown neuronal migration phenotype
PAC1 has ligand-independent and dimer-dependent intrinsic/basal activity, conferring cells with anti-apoptotic activities against serum withdrawal, which is involved in the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signal and is associated with the endocytosis of PAC1 dimers.
PACAP (show ADCYAP1 Antibodies) and PAC1-R expression increased in cumulus cells isolated at different times after treatment with human chorionic gonadotropin.
These results suggest that Sp1 (show SP1 Antibodies) cross-linking might be crucial in negative regulation of PAC1 gene expression due to TG2 (show TGM2 Antibodies) in OGD (show FGFR1 Antibodies)-induced ER stress.
This study demonistrated that pac1r expression in reactive astrocytes induced by global brain ischemia in mice.
PAC1R mRNA expression in the hippocampus was significantly elevated on day 7 after ischemia induced by bilateral common carotid artery occlusion. .
These results suggest that, in fish, PACAP (show VIPR2 Antibodies) and PAC1-R may play a role in brain development.
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
PACAP receptor 1
, PACAP type I receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
, pituitary adenylate cyclase-activating polypeptide type I receptor
, type I adenylate cyclase activating polypeptide receptor
, PACAP type IA receptor
, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
, adenylate cyclase activating polypeptide 1 type 1 receptor
, pituitary adenylate cyclase activating polypeptide 1 receptor (1)
, pituitary adenylate cyclase activating polypeptide receptor
, pituitary adenylate cyclase-activating polypeptide type IA receptor
, PAC1 receptor
, adenylate cyclase activating polypeptide 1 receptor 1
, pituitary adenylate cyclase activating polypeptide 1 receptor