Browse our anti-Adenosine A2a Receptor (ADORA2A) Antibodies

Pig (Porcine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.

2. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.

3. Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.

4. Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.

5. mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Antibodies)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Antibodies)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells

Zebrafish Adenosine A2a Receptor (ADORA2A) interaction partners

Rabbit Adenosine A2a Receptor (ADORA2A) interaction partners

1. Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Antibodies)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.

Human Adenosine A2a Receptor (ADORA2A) interaction partners

1. Report prognostic impact of ADORA2A expression in non-small lung cancers.

2. genetic association studies in population in Germany: Data suggest that an SNP in ADORA2A (1976T/C, rs5751876) is associated with interoceptive (resting) and exteroceptive (executive function/task-based) processing in frontal lobe and insular cortex neural networks. Facilitated processing of interoceptive/exteroceptive information in salience network is suggested to promote development of anxiety and anxiety disorders.

3. A2A receptor stimulation promotes collagen type III synthesis via the activation of canonical and non-canonical beta-catenin (show CTNNB1 Antibodies), consistent with a role for A2A receptors in dermal fibrosis and scarring.

4. It is significantly associated with hippocampal volume and the minor allele of rs9608282 in ADORA2A is associated with larger hippocampal volumes and better memory.

5. Study corroborated results from a previous report that described interactions between ADORA2A and CYP1A2 (show CYP1A2 Antibodies) polymorphisms and coffee consumption in Parkinson's disease.

6. However, the contribution of the A2AR to the control of impulsive reward seeking remains unknown. Using mice that were exposed to differential reward of low rate (DRL) schedules during Pavlovian-conditioning, second-order schedule discrimination, and the 5-choice serial reaction time task (5 (show KCNK15 Antibodies)-CSRTT), we demonstrate that deficits of A2AR function promote impulsive responses.

7. Western blot analysis indicates that the A2A receptor is more abundant in the hippocampus of medial temporal lobe epilepsy patients compared to control individuals. Immunoreactivity against the A2A receptor predominates in astrocytes staining positively for the glial fibrillary acidic protein (show GFAP Antibodies).

8. Results suggest that the combination of the ADORA2A rs2298383TT and MTHFR (show MTHFR Antibodies) 1298AC-677CT genotypes might lead to a low risk of nodule formation in patients treated with methotrexate.

9. results unveil intracellular signaling pathways targeted by the A2AR, some of which might be key in modulating neutrophil functions.

10. Calcium modulates calmodulin-ACTN1 (show ACTN1 Antibodies) interaction with and agonist-dependent internalization of the adenosine A2A receptor.

Mouse (Murine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. The astrocytic Lrp4 (show CORIN Antibodies) plays an important role in ischemic brain injury response. Lrp4 (show CORIN Antibodies) deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling.

2. the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH (show NF2 Antibodies) 5826 (SCH (show NF2 Antibodies)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (show IL17A Antibodies)(+), RORgammat(+), Foxp3 (show FOXP3 Antibodies)(+), and IL-10 (show IL10 Antibodies)(+) in CD4 (show CD4 Antibodies)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.

3. Absence of A2AAR increases cochlear resistance to acoustic trauma.

4. Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder.

5. Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK (show EPHB2 Antibodies)/Akt (show AKT1 Antibodies)/HIF-1alpha (show HIF1A Antibodies) pathway.

6. it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 (show FPR2 Antibodies) were mediated successively by the PGD2 (show PTGDS Antibodies)-DP1 (show REEP5 Antibodies) receptor, adenosine-A2A receptor, and GABA-GABAA (show GABRg1 Antibodies) receptor systems downstream of the FPR2 (show FPR2 Antibodies).

7. Study focused on the impact of A2A receptor deletion (A2A receptor knockout, A2AKO) on motivation for social exploration. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to wild type mice.

8. Data indicate A2ARs exert minor effects in un-stressed myocardium and selectively suppress NFkappaB and JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) signalling and cardiac injury without influencing cardiac depression in endotoxemia.

9. The three receptor sets considered (mAChR (show CHRM3 Antibodies), AR and TrkB (show NTRK2 Antibodies) receptors) intervene in modulating the conditions of the competition between nerve endings.

10. High A2aR expression is associated with Melanoma Metastasis.

Rhesus Monkey Adenosine A2a Receptor (ADORA2A) interaction partners

1. Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.

Horse (Equine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. Activation of adenosine A(2A) receptors inhibited ROS (show ROS1 Antibodies) production by LPS (show IRF6 Antibodies)-stimulated equine neutrophils in a cAMP-dependent manner.