Browse our anti-Adenosine A2a Receptor (ADORA2A) Antibodies

Pig (Porcine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.

2. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.

3. Activation of adenosine A2A receptors in hypoxic conditions is associated with an enhanced vasorelaxation in porcine coronary arteries.

4. Adenosine evokes dilation of porcine pial arterioles via parallel activation of endothelial and smooth muscle AA receptors.

5. Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.

6. Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.

7. hypoxia-induced coronary artery dilatation is not mediated by increased adenosine produced within the artery wall but might be facilitated by increased adenosine sensitivity at the A(2A) receptor level

Horse (Equine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. Activation of adenosine A(2A) receptors inhibited ROS production by LPS-stimulated equine neutrophils in a cAMP-dependent manner.

Rhesus Monkey Adenosine A2a Receptor (ADORA2A) interaction partners

1. Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.

2. report a differential, activation state-specific expression of ADORA in microglia and uncover a role for A(3)R as dynamically regulated suppressors of A(2A)R-mediated inhibition of TLR-induced responses

Zebrafish Adenosine A2a Receptor (ADORA2A) interaction partners

1. Expressed primarily within the central nervous system. Zebrafish AdRs may serve as useful targets for testing novel therapeutic strategies for the treatment of Parkinson's disease.

Human Adenosine A2a Receptor (ADORA2A) interaction partners

1. Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A2A receptor.

2. Our data support an important role for ADORA2A rs2298383 single nucleotide polymorphism in clinical heterogeneity associated with depression

3. The cryo-EM density map also indicates regions that are flexible in comparison to the crystal structures, which unexpectedly includes regions in the ligand binding pocket.

4. Molecular modeling of the human A2a adenosine receptor.

5. inflammatory state of adipose tissue is not affected by the anti-inflammatory response of the A2a-adenosine system and miR-221/PTEN

6. findings may open a new conceptual framework to understand the role of coordinated adenosine-endocannabinoid signaling in the indirect striatal pathway, which may be relevant in motor function and neurodegenerative diseases.

7. this study demonstrated that the Haemophilus influenzae infection stimulated A2A and A2B adenosine receptors.

8. miR-15 modulates inflammatory and immune responses by suppressing the expression of adenosine A2a receptor (A2aAR) and regulating the NF-kappaB cascade.

9. Authors show that engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits the maturation of natural killer (NK) cells. Both global and NK-cell-specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment.

10. the A2AR-D2R heterotetramer-AC5 complex sustains the canonical antagonistic Gs-Gi interaction at the adenylyl cyclase level

11. Here, ligand-binding kinetics of the full-length human adenosine A2A receptor (A2AR) reconstituted in detergent micelles were measured using a fluorescently labeled ligand via fluorescence anisotropy.

12. alpha2A- and alpha2C-adrenoceptors are functional receptors for norepinephrine, dopamine, and other previously assumed selective D2-like receptor ligands.

13. Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations have been described.

14. monocyte-derived macrophages from ankylosing spondylitis patients expressed increased levels of A2AAR and reduced levels of A1 and A2BAR compared to healthy controls

15. expression A2AR mRNA in PBMCs was associated with asthma severity. Foxp3 mRNA, TGF-beta, and FEV1%pred positively correlated with A2AR mRNA in asthma.

16. This study reported associations between the c.1083T>C polymorphism in the adenosine A2A receptor gene (ADORA2A) and sleep variables

17. Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation has been reported.

18. These data indicate that low [Na(+)] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidechain dynamics substantially differ between agonist (NECA) and inverse agonist (ZM241385) bound receptors, with the inverse agonist suppressing fast picosecond-nanosecond timescale motions at the G protein binding site.

19. Low adenosine A2a receptor expression is associated with ulcerative colitis.

20. Results demonstrate that A2AR act on GR nuclear translocation and GR-dependent transcriptional regulation which suggest that A2AR is a major regulator of GR function and that this functional interconnection may be a trigger to age-related memory deficits.

Mouse (Murine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. these results revealed the importance of GPR37 regulating A2A R-dependent locomotor sensitization and synaptic plasticity in the basal ganglia circuitry.

2. The authors findings reveal a distinctive endocrine role of brown adipose tissue in hypertensive cardiac remodeling via activating A2AR/FGF21 pathway.

3. The astrocytic A2A receptor is an important sensor that regulates microglial activation in a model of Sandhoff disease.

4. protective role in obesity-associated adipose tissue inflammation

5. A2AR may be involved in regulating the impairment of autophagic flux in response to brain injury.

6. A2a receptor increase cell viability, proliferation and insulin release through PKA/Akt/IPP-1/CREB signaling pathway

7. our results highlight the A2A Rs as a crucial regulator not only for NMDAR responses, but also for regulating ERK1/2 signaling and its downstream pathways, leading to gene expression, synaptic plasticity, and memory consolidation

8. These results demonstrate that acute alpha2-adrenergic stimulation suppresses glucose oxidation in beta-cells independent of nutrient availability and insulin exocytosis, while cAMP concentrations are elevated.

9. this study shows that GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

10. This study showed that synaptic A2AR critically control synaptic excitotoxicity, which underlies the development of convulsions-induced neurodegeneration.

11. A2A receptor activation at EAE onset helps reduce the effects of Th1 stimulation on BBB permeability, indicating that A2A receptor mediates BBB function in CNS demyelinated disease.

12. Results demonstrate that agonism of either peripheral A2AAR or central A2BAR causes hypothermia. Thus, agonism at any one of the four canonical adenosine receptors, A1AR, A2AAR, A2BAR, or A3AR can cause hypothermia. This four-fold redundancy in adenosine-mediated initiation of hypothermia may reflect the centrality of hypothermia as a protective response.

13. Authors show that engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits the maturation of natural killer (NK) cells. Both global and NK-cell-specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment.

14. Results show that A2ARs are important molecules that are required for gammadelta T cells to exert their enhancing activation. Blockade of A2AR function on gammadelta T cells should allow us to tip the enhancing and inhibiting function of gammadelta T cells toward the latter.

15. protective role in obesity-associated nonalcoholic fatty liver disease attributable to the direct effects of A2AR on altering inflammatory and metabolic responses of macrophages and hepatocytes

16. Study demonstrates that cognitive functions, including spatial memory and mood, are impaired due to acute hypobaric hypoxia (HH); and demonstrate that genetic inactivation of A2AR prevented spatial memory impairment in acute HH model of mice. The underlying mechanism might include microglia-mediated neuroinflammation via A2AR activation in the hippocampus.

17. Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression.

18. The present study evaluates the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population.

19. Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.

20. importance for MC5r and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients

Rabbit Adenosine A2a Receptor (ADORA2A) interaction partners

1. Selective activation of A(1), A(2A), or A(3) adenosine receptors provides significant protection against lung ischemia-reperfusion injury.

2. Study reveals presence of adenosine A(2A) and A(2B) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.