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mutation of ARHGEF18 is a likely cause of inherited retinal dystrophy (show MERTK Proteins)
CRB3A recruits p114RhoGEF and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA (show RHOA Proteins) activation levels.
LKB1 (show STK11 Proteins) and p114RhoGEF control RhoA (show RHOA Proteins) activity in bronchial epithelial cells to promote apical junction assembly.
Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.
In its regulation of the circumferential actomyosin tensile system, Lulu2 interacts with and activates p114RhoGEF at apical cell-cell junctions.
Data indicate that p114RhoGEF is a component of a junction-associated Rho signalling module that drives spatially restricted activation of RhoA (show RHOA Proteins) to regulate junction formation and epithelial morphogenesis.
p114-RhoGEF and Lfc (show ARHGEF2 Proteins) are critically involved in Wnt-3a (show WNT3A Proteins)- and Dvl (show DVL2 Proteins)-induced RhoA (show RHOA Proteins) activation and neurite retraction in N1E-115 cells.
data showed that the novel guanine nucleotide exchange factor (show RASGRF1 Proteins) p114RhoGEF regulates the activity of RhoA (show RHOA Proteins) and Rac1, and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
rho/rac guanine nucleotide exchange factor (GEF) 18
, Rho/Rac guanine nucleotide exchange factor (GEF) 18
, Rho-specific guanine nucleotide exchange factor p114
, 114 kDa Rho-specific guanine nucleotide exchange factor
, Rho/Rac guanine nucleotide exchange factor 18
, rho guanine nucleotide exchange factor 18
, septin-associated RhoGEF