Browse our FYVE, RhoGEF and PH Domain Containing 1 Proteins (FGD1)

Human FYVE, RhoGEF and PH Domain Containing 1 (FGD1) interaction partners

1. Sequencing analyses in numerous types of cancer have found missense mutations in the FGD1 gene in metastatic tumors.

2. A novel variant in FGD1 (a novel hemizygous mutation in FGD1 c.53del (p.Pro18Argfs*106) for which the mother is heterozygous) was found in an Emirati family with two brothers suffering from Aarskog-Scott syndrome. The variant is predicted to be a null mutation, and this is the first report of its kind from the United Arab Emirates.

3. Splice site mutation of FGD1 gene is associated with Aarskog-Scott syndrome patient with a large anterior fontanel.

4. No significant association was observed between IDD (show COL9A3 Proteins) and allele or genotype frequencies, or the haplotype of the 5 SNPs of the FGD1 gene in the Chinese population.

5. branch point variant in FGD1 identified by exome sequencing in Aarskog-Scott syndrome

6. Authors discuss the hypothesis that FGD1 might be an important regulator of events controlling extracellular matrix remodelling and possibly cell invasion in physiological and pathological settings.

7. The faciogenital dysplasia 1 (FGD1)gene encodes for a protein involved in skeletal and neuronal development.

8. This is the first report of inheritance by germline mosaicism for the FGD1 gene

9. These results demonstrate an important role for FGD1/Cdc42 (show CDC42 Proteins) signaling in human mesenchymal stem cells osteogenesis.

10. This study showed that the proline-rich doman of FGD1 is critical for persistent cell migration; FGD1 also augments EGF (show EGF Proteins)-stimulated c-Jun (show JUN Proteins) NH(2)-terminal kinase (JNK (show MAPK8 Proteins)) activation.

Cow (Bovine) FYVE, RhoGEF and PH Domain Containing 1 (FGD1) interaction partners

1. results identify Fgd1 as a TGF-beta (show TGFB1 Proteins)-regulated guanine exchange factor and, as such, the first guanine exchange factor to be involved in the process of cytokine-induced podosome formation

Mouse (Murine) FYVE, RhoGEF and PH Domain Containing 1 (FGD1) interaction partners

1. activation of MLK3 specifically by FGD1/CDC42 (show CDC42 Proteins) is important for skeletal mineralization

2. this study provides novel in vitro and in vivo evidence that Fgd1 specifically and directly interacts with cortactin and mAbp1, and that these interactions play an important role in regulating the actin cytoskeleton and, subsequently, cell shape.

3. FGD1 is preferentially associated with the trans-Golgi network (TGN (show TG Proteins)), suggesting its involvement in export of proteins from the Golgi.