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anti-Mouse (Murine) ITSN1 Antibodies:
anti-Human ITSN1 Antibodies:
anti-Rat (Rattus) ITSN1 Antibodies:
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component of Reelin (show RELN Antibodies) signaling that acts predominantly by facilitating the VLDLR (show VLDLR Antibodies)-Dab1 (show DAB1 Antibodies) axis to direct neuronal migration in the cortex and hippocampus and to augment synaptic plasticity
Immunohistochemistry and histological and morphometric analyses revealed a twofold increase in proliferative endothelial cells and a 1.35-fold increase in proliferative alpha-smooth muscle actin (show ACTG2 Antibodies)-positive cells in the lungs of ITSN-deficient mice.
PRRT2 (show PRRT2 Antibodies) interacts with the Src (show SRC Antibodies) homology 3 domain-bearing protein Intersectin 1, an intracellular protein (show CKAP2 Antibodies) involved in synaptic vesicle cycling.
Endocytic deficiency caused by ITSN knock-down modified Alk5 (show TGFBR1 Antibodies) endocytic trafficking and enhances its degradation
It was concluded that miR (show MLXIP Antibodies)-194 regulates ROMK (show KCNJ1 Antibodies) channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.
ITSN1 enhances Cbl (show CBL Antibodies) activity, in part, by modulating the interaction of Cbl (show CBL Antibodies) with Spry2 (show SPRY2 Antibodies) through recruitment of Shp2 (show PTPN11 Antibodies) phosphatase to the Cbl (show CBL Antibodies)-Spry2 (show SPRY2 Antibodies) complex.
This study demonistrated that Itsn1 mutant mice showed severe deficits in Morris water maze and contextual fear memory tasks.
ITSN1 binds Pro-rich regions in both Cbl (show CBL Antibodies) and Spry2 (show SPRY2 Antibodies), and interaction of ITSN1 with Spry2 (show SPRY2 Antibodies) disrupts Spry2 (show SPRY2 Antibodies)-Cbl (show CBL Antibodies) interaction, resulting in enhanced ubiquitylation of the EGFR (show EGFR Antibodies).
Data show that intersectin-SH3D interacts directly with a small region of CdGAP (show ARHGAP31 Antibodies) highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif.
Swapping of SH3 domain binding partners might act as a switch controlling the actin nucleation activity of intersectin 1L.
WIP (show WIPF1 Antibodies) enhances the interaction of N-WASP with ITSN1 and promotes ITSN1/beta-actin (show ACTB Antibodies) association.
Here, we discover that intersectin-s binds DENND2B (show ST5 Antibodies), a guanine nucleotide exchange factor (show RASGRF1 Antibodies) for the exocytic GTPase (show RACGAP1 Antibodies) Rab13 (show RAB13 Antibodies), and this interaction promotes recycling of ligand-free EGFR (show EGFR Antibodies) to the cell surface. Our study thus reveals a novel mechanism controlling the fate of internalized EGFR (show EGFR Antibodies) with important implications for cancer.
study reports that vaccinia virus A36 contains three NPF motifs that interact with the Eps15 (show EPS15 Antibodies) homology (EH) domains in intersectin-1 and Eps15 (show EPS15 Antibodies) to promote the release of virus from infected cells and their subsequent spread
Silencing ITSN1 in neuroblastoma (show ARHGEF16 Antibodies) cells led to decreased tumor growth in an orthotopic mouse model. Orthotopic animal models can provide insight into the role of ITSN1 pathways in neuroblastoma (show ARHGEF16 Antibodies) tumorigenesis.
These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
Study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target
Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation
ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Silencing ITSN1 significantly inhibits the anchorage independent growth of tumor cells in vitro.
the neuron-specific isoform of the stable tubule-only polypeptide (show MAP6 Antibodies) (STOP) interacts with SH3A domain of ITSN1.
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
, intersectin 1
, intersectin 1, isoform 1
, EH and SH3 domains protein 1
, Eh domain, SH3 domain regulator of endocytosis 1
, intersectin (SH3 domain protein 1A)
, intersectin short form 2 variant 2
, SH3 domain-containing protein 1A
, Src homology 3 domain-containing protein
, human intersectin-SH3 domain-containing protein SH3P17
, intersectin 1 short form variant 3
, intersectin 1 short form variant, 11
, intersectin short variant 12
, EH domain and SH3 domain regulator of endocytosis 1
, intersectin 1 (SH3 domain protein 1A)