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Human Monoclonal MAGED1 Primary Antibody for WB - ABIN1944790
Wen, Xue, Qin, Yu, Zhang, Zhao, Gao, Gu, Li: hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. in FEBS letters 2004
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Mouse (Murine) Monoclonal MAGED1 Primary Antibody for IC, IF - ABIN2452045
Kuwajima, Nishimura, Yoshikawa: Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
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Our results indicate that NRAGE subcellular localization is related to radiation resistance of esophageal carcinoma cell and EMT (show ITK Antibodies) may be involved in NRAGE subcellular location.
NRAGE upregulation was correlated with advanced TNM (show ODZ1 Antibodies) stage, local invasion, and poor survival. Importantly, NRAGE could serve as an independent prognostic factor in patients with gastric cancer.
The nuclear localized NRAGE interacts with RNF8 (show RNF8 Antibodies) and BARD1 (show BARD1 Antibodies) to mediate the resistance of esophageal carcinomas cells against DNA-damaging agents.
these results demonstrate the effective anti-autophagic of NRAGE in non-small-cell lung cancer cells through AMPK (show PRKAA1 Antibodies)/Ulk1 (show ULK1 Antibodies)/Atg13 (show ATG13 Antibodies) autophagy signaling pathways. Therefore, NRAGE could be used as a potential therapeutic target for lung cancer.
MAGED1 binds and positively regulates the transcriptional activity of family members SIM1 (show SIM1 Antibodies), SIM2 (show SIM2 Antibodies), NPAS4 (show NPAS4 Antibodies) and ARNT2 (show ARNT2 Antibodies), but does not interact with AhR (show AHR Antibodies), HIF1alpha (show HIF1A Antibodies) and ARNT (show ARNT Antibodies). This interaction is mediated by PAS (show PASK Antibodies) repeat regions which also form the interface for bHLH PAS (show PASK Antibodies) dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS (show PASK Antibodies) dimers.
our surprise, NRAGE induces nuclear localization of beta-catenin (show CTNNB1 Antibodies) and increases its DNA binding ability. Further studies reveal that NRAGE leads to the modification of beta-catenin/Arm with O-linked beta-N-acetylglucosamine (O-GlcNAc (show OGT Antibodies)), and failure of the association between beta-catenin/Arm and pygopus(pygo) protein, which is required for transcriptional activation of Wnt (show WNT2 Antibodies) target genes. Therefore, our findings suggest a ...
Loss of GSPT2 (show GSPT2 Antibodies) and/or MAGED1 function may contribute to the intellectual disability.
The ectopic subcellular localization of NRAGE mediated nuclear translocation of beta-catenin (show CTNNB1 Antibodies).
High NRAGE expression is associated with esophageal carcinomas.
MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages.
Both transient and stable expression of Necdin (show NDN Antibodies) induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation.
MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model
Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB).
NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB (show NFKB1 Antibodies) signalling pathway.
Show Ror2 (show ROR2 Antibodies) expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 (show ROR2 Antibodies) is a potential factor in the tumorigenesis and metastasis in a Src (show SRC Antibodies)-dependent manner that is negatively regulated by NRAGE.
We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes
Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD (show BEST1 Antibodies))
the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT (show SLC6A4 Antibodies) ubiquitylation.
XIAP (show XIAP Antibodies)-TAB1 (show TAB1 Antibodies)-TAK1 (show NR2C2 Antibodies) complex is dependent on NRAGE for IKK-alpha (show CHUK Antibodies)/beta phosphorylation and NF-kappaB (show NFKB1 Antibodies) activation.
MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1 (show ARNTL Antibodies), Rev-erbalpha (show NR1D1 Antibodies) and E4bp4 (show NFIL3 Antibodies) expression through the Rev-Erbalpha (show NR1D1 Antibodies)/ROR responsive elements (RORE).
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
melanoma antigen family D, 1
, melanoma-associated antigen D1
, melanoma-associated antigen D1-like
, MAGE tumor antigen CCF
, MAGE-D1 antigen
, neurotrophin receptor-interacting MAGE homolog
, sertoli cell necdin-related gene protein 1