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Human Polyclonal PDE1A Primary Antibody for CM, ICC - ABIN2747069
Whitehead, Earle, Fetter, Xu, Hartman, Chan, Zhao, Piazza, Klein-Szanto, Pamukcu, Alila, Bunn, Thompson: Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. in Molecular cancer therapeutics 2004
Show all 15 Pubmed References
Human Polyclonal PDE1A Primary Antibody for ELISA, WB - ABIN4344404
Cabanero, Laje, Detera-Wadleigh, McMahon: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample. in Pharmacogenetics and genomics 2009
Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness.
These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1 (show UHRF1 Antibodies).
PDE1A is permanently activated in human spermatozoa
Ca2 (show CA2 Antibodies)+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2 (show CA2 Antibodies)+
PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
Variants in PDE1A are not associated with citalopram response in patient with depression.
PDE1A is unlikely to play an important role in antidepressant outcome in this sample
These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure.
These results prove that the kinetic properties of PDE (show TWIST1 Antibodies) isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2 (show CA2 Antibodies)+]i.
new variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase (show PDE3A Antibodies) 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function.
a novel role for Ca(2 (show CA2 Antibodies)+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG (show PRKG1 Antibodies)-dependent mechanism, thereby demonstrating Ca(2 (show CA2 Antibodies)+) and cGMP signaling cross-talk during cardiac hypertrophy.
The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM (show KRIT1 Antibodies)-activated plasma membrane-bound PDE1A, linked to M(2)AChR.
Although cAMP regulation by PDE 1 may occur early during capacitation, downstream events appear to prevent full capacitation from occurring prematurely.
analysis of calmodulin (show KRIT1 Antibodies)-dependent cyclic nucleotide phosphodiesterase (show PDE3A Antibodies) (PDE1) splice variants from bovine cardiac muscle
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1\; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
, calmodulin-activated cyclic nucleotide phosphodiesterase
, phosphodiesterase 1A, calmodulin-dependent
, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like
, cyclic nucleotide phosphodiesterase 1a
, 61 kDa Cam-PDE
, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
, cam-PDE 1A
, 3'-RACE clone 8 phosphodiesterase 1A
, 3-RACE clone 8 phosphodiesterase 1A
, calmodulin-dependent phosphodiesterase type 1
, nucleotide phosphodiesterase, 3'-5'-cyclic