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Caenorhabditis elegans (C. elegans) Polyclonal RIT2 Primary Antibody for EIA, IP - ABIN117958
Furukawa, Zhang, McCarville, Ohta, Xiong: The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. in Molecular and cellular biology 2000
Show all 14 Pubmed References
Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor
An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients.
Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter.
RNF7 (show RNF7 Antibodies) gene variant is associated with the risk of developing liver fibrosis and cirrhosis in an Eastern European population.
RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese.
MAF1 (show MAF1 Antibodies), RNF7 (show RNF7 Antibodies) and SETD3 (show SETD3 Antibodies) are identified as PCNA (show PCNA Antibodies)-associated proteins in human cells and given this interaction with PCNA (show PCNA Antibodies), Maf1 (show MAF1 Antibodies), RNF7 (show RNF7 Antibodies), and SetD3 (show SETD3 Antibodies) are potentially involved in DNA replication, DNA repair, or associated processes.
findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations
performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals
Its polymorphism is associated with Parkinson's disease in a Han Chinese population.
The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology.
These studies confirm the expression of RIT2 in retinal neuronal cells.
stimulation of PC6 (show PCSK5 Antibodies) cells with either epidermal growth factor (show EGF Antibodies) or nerve growth factor (NGF) results in rapid activation of Rin
The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation
Rin and Rit (show RIT1 Antibodies) Bind to PAR6 (show PARD6A Antibodies) GTP (show AK3 Antibodies)-dependently and regulate cell transformation
Neuron-specific small GTPase (show RACGAP1 Antibodies) Rin is involved in downstream signaling of plexin B3 (show PLXNB3 Antibodies).
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
GTP-binding protein Rit2
, GTP-binding protein Roc2
, Ric-like, expressed in neurons
, ras-like protein expressed in neurons
, ras-like without CAAX protein 2
, CKII beta-binding protein 1
, RING-box protein 2
, regulator of cullins 2
, sensitive to apoptosis gene protein
, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
, zinc RING finger protein SAG
, Ras-like without CAAX 1
, RAS-like protein expressed in neuron
, Ras-like without CAAX 2