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The present results have uncovered new factors underlying successful axon regeneration in the fish CNS: Binding of Nogo-66 of fish RTN-4 to NgR is growth promoting on fish retinal ganglion cell axon growth
Data suggest that localized Nogo/Nogo66 expression defines inhibitory territories that through repulsion restrict axon growth to permissive regions.
miR-10 can promote microglia cell proliferation and inhibit the inflammatory cytokine secretion via targeting the NgR gene to down-regulate its expression.
Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing.
NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke
Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428.
Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2.
(188)Re-NGR-VEGI has the potential as a theranostic agent.
Messenger RNA expression from RTN4R in human cortical brain tissue correlated significantly with the genotypes of rs701427. Observations suggest that a functional RTN4R gene variant is associated with sporadic ALS.
Authors highlight the structural and biochemical aspects of the interaction of Nogo receptors (R1 and R2) with myelin inhibitors such as MAG, Nogo A and OMgp.[Review]
NgR1 is a neural entry mediator for mammalian reovirus.NgR1 is required for efficient infection of primary cortical neurons by reovirus.
Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR).
This study demonistrated that alterations in DTI metrics suggest white matter microstructural anomalies of the cerebral cortex in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene.
knockdown of NgR enhanced invasion and adhesion but increased cell apoptosis in C6 cells, suggesting that Nogo-66/NgR might have complex effects on glioma cells.
Strong overexpression of Nogo receptor 1 in forebrain neurons impairs aspects of cognitive function but does not alter plaque load in plaque-forming transgenic animals.
After optic nerve crush injury, transgenic NgR1-deficient neurons regenerate retinal ganglion axons as extensively as do zymosan-injected, macrophage-activated wild-type mice.
Expression of Nogo-66 receptor in human astrocytoma is correlated with tumor malignancy.
Nogo receptor 3, a paralog of NgR1,functions as a NgR1 co-receptor for Nogo-66.
These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin.
The results of this study suggested that Lack of association of the RTN4R genetic variations with risk of schizophrenia and SPEM abnormality in a Korean population.
A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1.
Kiaa0319-like protein interacts with Nogo Receptor 1, supporting the idea that Kiaa0319-like protein participates in axon guidance.
These data suggest that NgR1 may regulate axo-myelin ultrastructure through Caspr-mediated adhesion, regulating the electrophysiological signature of myelinated axons of central nervous system.
Nogo-A and NgR1 interactions may contribute to axonal branching in lateral olfactory tract development
determine the expression pattern of NgR1 in the retina by co-labeling neurons with characterized markers of specific retinal neurons
The results of this study indicated that Nogo-66 signaling limits LTP via the ROCK2-Cofilin pathway to control the dynamics of the actin cytoskeleton.
Results demonstrated that nogo receptor 1 (NgR1) expression is upregulated in the olfactory epithelium (OE) after injury, which suggests that NgR1 might be involved in the regeneration of the OE.
Here we identify that the nogo-66 receptor 1 gene restricts an early and essential step in OD plasticity to the critical period. These findings link the emerging circuit-level description of OD plasticity to the genetic regulation of the critical period. Understanding how plasticity is confined to critical periods may provide clues how to better treat amblyopia.
Nogo Receptor 1 limits ocular dominance plasticity but not turnover of axonal boutons in a model of amblyopia
Results show that Nogo receptor 1 is a negative regulator of both structural synaptic plasticity and dendritic complexity in a brain region-specific manner, and highlight anterior cingulate cortex as a key area for memory-related plasticity.
Rtn4r expression was reduced in spinal motor neurons from mice with a transgenic model of ALS.
This study detected the expression of NgR1 in microglia during development and found that NgR1 protein expression increased significantly in microglia with aging.
Ngr1 regulates tactile and motor task performance, it does not limit the rate of tactile or motor learning nor determine the low set point for synaptic turnover in adult sensory cortex.
the Nogo/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases.
Genetic ablation of NgR1 may lead to significant recovery in locomotor function after spinal cord injury
NgR1 is required for efficient infection of primary cortical neurons by reovirus.
NogoA receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside.
NgR1 functions with parvalbumin interneurons to limit plasticity of binocularity, but its expression is required more extensively to limit improvement of visual acuity following chronic deprivation.
NgR1 has little if any effects on the repertoire of immune cells, their activation and trafficking to the CNS.
ngr(-/-) animals show slower acquisition of a spatial learning and memory task
siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
, reticulon-4 receptor
, reticulon-4/Nogo receptor
, reticulon 4 receptor
, nogo receptor
, nogo receptor; Nogo-66 receptor
, Nogo66 receptor
, nogo-66 receptor