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The present results have uncovered new factors underlying successful axon regeneration in the fish CNS: Binding of Nogo (show RTN4 Proteins)-66 of fish RTN-4 (show RTN4 Proteins) to NgR is growth promoting on fish retinal ganglion cell axon growth
Data suggest that localized Nogo (show RTN4 Proteins)/Nogo66 expression defines inhibitory territories that through repulsion restrict axon growth to permissive regions.
Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing.
NgR1 (show NEUROG1 Proteins) ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke
Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428.
Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1 (show NEUROG1 Proteins), RhoA (show RHOA Proteins), and ROCK2 (show ROCK2 Proteins).
(188)Re-NGR-VEGI (show TNFSF15 Proteins) has the potential as a theranostic agent.
Messenger RNA expression from RTN4R in human cortical brain tissue correlated significantly with the genotypes of rs701427. Observations suggest that a functional RTN4R gene variant is associated with sporadic ALS.
Authors highlight the structural and biochemical aspects of the interaction of Nogo (show RTN4 Proteins) receptors (R1 and R2) with myelin inhibitors such as MAG (show MAG Proteins), Nogo A (show RTN4 Proteins) and OMgp (show OMG Proteins).[Review]
NgR1 (show NEUROG1 Proteins) is a neural entry mediator for mammalian reovirus.NgR1 is required for efficient infection of primary cortical neurons by reovirus.
Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1 (show LINGO1 Proteins)) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR (show NGFR Proteins)).
This study demonistrated that alterations in DTI metrics suggest white matter microstructural anomalies of the cerebral cortex in 22q11.2DS. Structural differences in ALIC appear to be associated with the Nogo-66 receptor gene.
Nogo-A (show RTN4 Proteins) and NgR1 (show NEUROG1 Proteins) interactions may contribute to axonal branching in lateral olfactory tract development
determine the expression pattern of NgR1 (show NEUROG1 Proteins) in the retina by co-labeling neurons with characterized markers of specific retinal neurons
The results of this study indicated that Nogo-66 signaling limits LTP via the ROCK2-Cofilin pathway to control the dynamics of the actin cytoskeleton.
Results demonstrated that nogo receptor 1 (NgR1 (show NEUROG1 Proteins)) expression is upregulated in the olfactory epithelium (OE) after injury, which suggests that NgR1 (show NEUROG1 Proteins) might be involved in the regeneration of the OE.
Here we identify that the nogo-66 receptor 1 gene restricts an early and essential step in OD plasticity to the critical period. These findings link the emerging circuit-level description of OD plasticity to the genetic regulation of the critical period. Understanding how plasticity is confined to critical periods may provide clues how to better treat amblyopia.
Rtn4r expression was reduced in spinal motor neurons from mice with a transgenic model of ALS.
This study detected the expression of NgR1 (show NEUROG1 Proteins) in microglia during development and found that NgR1 (show NEUROG1 Proteins) protein expression increased significantly in microglia with aging.
Ngr1 (show NEUROG1 Proteins) regulates tactile and motor task performance, it does not limit the rate of tactile or motor learning nor determine the low set point for synaptic turnover in adult sensory cortex.
the Nogo (show RTN4 Proteins)/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases.
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
, reticulon-4 receptor
, reticulon-4/Nogo receptor
, reticulon 4 receptor
, nogo receptor
, nogo receptor; Nogo-66 receptor
, Nogo66 receptor
, nogo-66 receptor