RTN4R Protein (His tag)
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- Target See all RTN4R Proteins
- RTN4R (Reticulon 4 Receptor (RTN4R))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This RTN4R protein is labelled with His tag.
- Purpose
- Recombinant Mouse Nogo Receptor/NgR Protein (His Tag)(Active)
- Sequence
- Met 1-Ser 447
- Characteristics
- A DNA sequence encoding the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was expressed, fused with a polyhistidine tag at the C-terminus.
- Purity
- > 97 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant Mouse RTN4R at 2 μg/ml (100 μl/well) can bind biotinylated human RTN4 (GST Tag) with a linear range of 0.04-0.625 μg/ml.
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- Discover our top product RTN4R Protein
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Reticulon 4 Receptor (RTN4R) (AA 1-473) protein (GST tag)
RTN4R Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Reticulon 4 Receptor (RTN4R) (Active) protein (His tag,Fc Tag)RTN4R Origin: Mouse Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Reticulon 4 Receptor (RTN4R) (AA 27-447) protein (His tag)Crystallography grade RTN4R Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Reticulon 4 Receptor (RTN4R) (AA 27-447) protein (His tag)Crystallography grade RTN4R Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- RTN4R (Reticulon 4 Receptor (RTN4R))
- Alternative Name
- Nogo Receptor/NgR (RTN4R Products)
- Synonyms
- NgR Protein, NGR Protein, NOGOR Protein, NgR1 Protein, Nogor Protein, reticulon 4 receptor Protein, rtn4r Protein, RTN4R Protein, Rtn4r Protein
- Background
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Background: Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
Synonym: NgR,NgR1,NOGOR,Rtn4r
- Molecular Weight
- 47 kDa
- NCBI Accession
- NP_075358
- Pathways
- Neurotrophin Signaling Pathway
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