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Thus, we concluded that fine-tuning expression of Bcl-3 is needed for proper CD4 (show CD4 Antibodies)(+) T-cell development and is required to sustain Th17-cell mediated pathology.
Bcl-3 suppressed colorectal tumor formation: Bcl-3-deficient mice were relatively protected from DSS (show PMP22 Antibodies)-induced epithelial damage and developed more polyps after AOM (show COL2A1 Antibodies)/DSS (show PMP22 Antibodies) treatment, although polyp size was unaffected.
this study implicates the intracellular protein (show CKAP2 Antibodies), BCL3, as a key mediator of the IL-10 (show IL10 Antibodies)-induced immunosuppressive macrophage phenotype
These results establish that Bcl3 positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 as a downstream molecule of LIF (show LIF Antibodies)/STAT3 (show STAT3 Antibodies) signaling in pluripotency maintenance.
Bcl3 reduces the inflammatory response in pancreas/biliary tissue by blocking ubiquitination and proteasome-mediated degradation of nuclear factor-kappaB p50 (show NFKB1 Antibodies) homodimers.
Low expression of IL-6 (show IL6 Antibodies) and TNF-alpha (show TNF Antibodies) correlates with the presence of the nuclear regulators of NF-kappaB (show NFKB1 Antibodies), IkappaBNS (show NFKBID Antibodies) and BCL-3, in the uterus of mice.
These findings demonstrate that Bcl-3 is required in dendritic cells to prime protective T-cell-mediated immunity to T. gondii
data show that BCL-3 makes extensive contacts with p50 (show LSP1 Antibodies) homodimers and in particular with ankyrin (show ANK Antibodies) repeats (ANK) 1 (show ANK1 Antibodies), 6, and 7, and the N-terminal region of Bcl-3.
The presence of a p50 (show LSP1 Antibodies)/Bcl-3 complex in nuclear extracts from cells of metastatic lung tissues.
In SOD1 (show SOD1 Antibodies) and Neurotomized mice the results of this studysuggest LC3 (show MAP1LC3A Antibodies), Fn14 (show TNFRSF12A Antibodies), Bcl3 and Gadd45a (show GADD45A Antibodies) as candidate genes involved in the maintenance of the severe atrophic state.
B-cell leukemia protein 3 (show HSPB3 Antibodies) (Bcl3) expressed in response to cytokine TWEAK (show TNFSF12 Antibodies) stimulation (experimental kidney injury) decreases TWEAK (show TNFSF12 Antibodies)-induced inflammatory and lethal responses.
Four gene signature (PTEN, PIK3C2A (show PIK3C2A Antibodies), ITPA (show ITPA Antibodies) and BCL3) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma (show MOK Antibodies).
Akt2 (show AKT2 Antibodies), Erk2 (show MAPK1 Antibodies), and IKK1 (show CHUK Antibodies)/2 phosphorylate Bcl3, converting Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA.
Bcl-3 knockdown enhanced the degradation of Smad3 (show SMAD3 Antibodies) but not Smad2 (show SMAD2 Antibodies) following TGFbeta (show TGFB1 Antibodies) treatment.
We have shown for the first time that BCL-3 promotes the growth of colorectal cancer cells through activation of the AKT (show AKT1 Antibodies) pathway, increasing tumour cell yield both in vitro and in vivo.
BCL3 serves as an oncogene (show RAB1A Antibodies) in glioma by modulating proliferation, cell cycle progression and apoptosis, and its oncogenic effects are mediated by the STAT3 (show STAT3 Antibodies) signaling pathway.
miR (show MLXIP Antibodies)-19b silencing promoted cell proliferation and cell cycle progression in gastric cancer cells and BCL3 was identified as a direct target of miR (show MLXIP Antibodies)-19b
Study confirmed that BCL-3 is overexpressed in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tissues and correlated with adverse clinicopathological features and poorer prognosis. BCL-3 can promote the growth of HCC (show FAM126A Antibodies) cells by promoting cell viability, proliferation and cell cycle progression through regulation of CCND1 (show CCND1 Antibodies) expression.
Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
B-cell CLL/lymphoma 3
, B-cell leukemia/lymphoma 3
, B-cell lymphoma 3 protein homolog
, B-cell lymphoma 3 protein
, B-cell lymphoma 3-encoded protein
, chronic lymphatic leukemia protein
, proto-oncogene BCL3