BCL3 antibody (Center)

Catalog No. ABIN653286

Product Details anti-BCL3 Antibody

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Binding Specificity: AA 249-277, Center

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This BCL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248~277 amino acids from the Center region of human BCL3.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BCL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 AA from the Central region of human BCL3.

Clone: RB23954

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.48 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-BCL3 antibody (ABIN653286)

Gehrke, Wörns, Huber, Hess, Straub, Hövelmeyer, Waisman, Kim, Schuppan, Galle, Schattenberg: "Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors." in: Journal of hepatology, Vol. 65, Issue 6, pp. 1188-1197, (2018) (PubMed).

Target Details for BCL3

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Alternative Name: BCL3 (BCL3 Products)

Synonyms: BCL3 antibody, AI528691 antibody, Bcl-3 antibody, BCL4 antibody, D19S37 antibody, B-cell CLL/lymphoma 3 antibody, B cell leukemia/lymphoma 3 antibody, BCL3 antibody, Bcl3 antibody

Background: BCL3 is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers.
Synonyms: Proto-oncogene BCL3, B-cell lymphoma 3 protein, BCL-3, D19S37, BCL4, BCL3

Molecular Weight: 46800 Da

Gene ID: 602

UniProt: P20749

Pathways: NF-kappaB Signaling, Maintenance of Protein Location, Protein targeting to Nucleus