Browse our anti-CD40 Ligand (CD40LG) Antibodies

Chimpanzee CD40 Ligand (CD40LG) interaction partners

1. specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein

Atlantic Salmon (Salmo salar) CD40 Ligand (CD40LG) interaction partners

1. identification and functional characterization of CD40L and CD40 from Atlantic salmon (Salmo salar); results provide evidence for the existence of a functional CD40L mediated costimulatory pathway in Atlantic salmon

Human CD40 Ligand (CD40LG) interaction partners

1. The ratio of CD40L(+)CD4(+) to CD4(+) T cells in the acute phase of neuromyelitis optica spectrum disorders was significantly higher than that in healthy controls.

2. This indicates that the reactions between red blood cell surface antigens and plasma antibodies do not play a role in the induction of CD40L expression.

3. Our data suggest a nonredundant role of CD40L-CD40 interaction in neutrophil development and function that could be improved in vitro by rhIFN-gamma, indicating a potential novel therapeutic application for this cytokine.

4. IL-17 and CD40L synergistically mediate the inflammatory response and remodelling associated with tissue injury and glomerular sclerosis in diabetic nephropathy

5. we describe, for the first time, the deleterious immunologic consequences of CD40LG duplication in a mother and son

6. increased expression levels of OX40 and OX40L were involved in the pathogenesis of Immune thrombocytopenia

7. the dependency of mantle cell lymphoma (MCL) cell lines on NFkappaB signaling and illustrated the ability of CD40L to activate the alternative NFkappaB pathway in MCL, was analyzed.

8. The decreased expression of CD40L in lymph nodes may be an important factor in tumor recurrence and progression in the oral squamous cell carcinoma patients.

9. Higher serum concentrations of sST2 and sCD40L in microvascular angina patients may be associated with inflammatory activation and coronary microvascular dysfunction.

10. associations between CD40L/IL-4 response and baseline ATM levels, induction of ATM, and phosphorylation of the ATM targets, p53 and H2AX. X-irradiation was used to demonstrate that CD40L/IL-4 stimulation tended to improve DNA damage repair.

11. Symptomatic chagasic patients were differentiated from asymptomatic patients based on the expression of CD154 and membrane TNF-alpha in TCD4+ and TCD8+ compartments, respectively.

12. the current study aimed to investigate the possible associations between CD40 polymorphisms and level of soluble CD154 protein with migraine.

13. this study reports the clinical and CD40L genetic features of six Iranian hyper IgM syndrome patients

14. the CD40 rs1883832 T allele acts as a risk factor for increased susceptibility to sepsis and may be involved in the process of sepsis through regulation of CD40 expression and plasma sCD40L levels.

15. Overexpression of CD40L-WT/CD40L-M in CD40+ NSCLC cells increased SA-beta-gal staining activity and inhibited DNA synthesis and cell proliferation.

16. T cell-stimulated CLL cells actively recruited monocytes, and CD40L was identified as the responsible T-cell factor that mediated recruitment.

17. this study shows that decreased serum levels of soluble CD40L correlate in treated patients with Relapsing-Remitting Multiple Sclerosis

18. In conclusion, we described a new pathway of platelet-monocyte interaction, mediated by sCD40L and oxidative stress that may contribute to the progression of endothelial dysfunction during Shiga toxin 2-associated hemolytic uremic syndrome.

19. show that sCD40L/alpha5beta1 interaction leads to platelet activation as evaluated in the human whole blood

20. In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15].

Mouse (Murine) CD40 Ligand (CD40LG) interaction partners

1. it is the combination of CD40L and the cytokines secreted by activated t-cells that licenses dendritic cellss and influences the effector class of the immune response

2. Deficiency of (hematopoietic) CD40L protects against dissecting aneurysm formation and reduces the incidence of fatal rupture. This is associated with a decreased accumulation and activation of inflammatory cells and a dampened protease activity in the arterial wall.

3. T-cell zone-specific TCRbeta repertoires revealed that CD154 deficiency shifts the distribution of Vbeta-Jbeta genes after antigen exposure

4. CD40L controls obesity-associated vascular inflammation, oxidative stress and endothelial dysfunction in mice and potentially humans.

5. These results suggest that combination of IL-21, anti-Tim1 and CD40L treatment induced B10 cell's IL-10 competency in vitro and inhibited periodontal bone loss in ligature-induced experimental periodontitis.

6. MR1-induced bone accrual was associated with increased Treg development and elevated production of cytotoxic T lymphocyte antigen 4, a costimulation inhibitor that promotes T cell anergy and CD8+ T cell expression of the bone anabolic ligand Wnt-10b.

7. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.

8. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis.

9. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 signaling

10. our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8(+) T-cell responses also under inflammatory conditions, CD40L expression by CD8(+) T cells themselves is dispensable in acute lymphocytic choriomeningitis virus infection.

11. Platelets promote allergic asthma through the expression of CD154.

12. CD40L does not play a functional role in experimental acute pancreatitis

13. The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes.

14. there is a major involvement of the CD40-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.

15. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.

16. although treated CD40 knockout mice remained healed, developed long-term immunity, and were resistant to secondary Leishmania major challenge, treated CD40L knockout reactivated their lesion after cessation of rIL-12 treatment.

17. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development.

18. Anti-OX40L mAb could prolong secondary heart allograft survival based on CD40/CD40L and LFA-1/ICAM-1 blockade.

19. CD40 on lymph node fibroblasts facilitated bidirectional communication with CD4(+) T cells via CD40-CD40L, thereby altering fibroblast gene expression of immune regulatory molecules.

20. CD40L mediates neointima formation via its classic receptor CD40 rather than via its recently described novel interaction with Mac-1.

Pig (Porcine) CD40 Ligand (CD40LG) interaction partners

1. CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells

Cow (Bovine) CD40 Ligand (CD40LG) interaction partners

1. Results demonstrated greater CD40 and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.

Rhesus Monkey CD40 Ligand (CD40LG) interaction partners

1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.