Browse our anti-CD40 Ligand (CD40LG) Antibodies

Chimpanzee CD40 Ligand (CD40LG) interaction partners

1. specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein

Atlantic Salmon (Salmo salar) CD40 Ligand (CD40LG) interaction partners

1. identification and functional characterization of CD40L and CD40 (show CD40 Antibodies) from Atlantic salmon (Salmo salar); results provide evidence for the existence of a functional CD40L mediated costimulatory pathway in Atlantic salmon

Human CD40 Ligand (CD40LG) interaction partners

1. In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15].

2. Study indicates that the rs1126535C/T polymorphism of CD154 gene was involved in the progression of Chinese SLE patients, probably by affecting the expression of CD154.

3. study found that plasma CD40L was associated with acute chest syndrome (ACS), and that sickle cell anemia (SCA)patients with a lifetime history of ACS (ACS+) presented significantly higher plasma CD40L and TSP-1 than patients who had never experienced ACS (ACS-)

4. this paper demonstrates importance of CD40 (show CD40 Antibodies)/CD40L signaling on IL-10 (show IL10 Antibodies)-producing regulatory B cells in Chinese children with Henoch-Schonlein purpura nephritis

5. Soluble CD40 ligand derived from serum is not correlated with early stage of multiple sclerosis.

6. Analysis of the early events after receptor engagement revealed that both TNF (show TNF Antibodies) and CD40L activate the classical NF-kappaB (show NFKB1 Antibodies) pathway, and confirm activation of the alternative by the latter. Furthermore, using genetic and pharmacological inhibition of the classical pathway we show that activation of the alternative occurs independently of the former. This reveals insights into NF-kappaB (show NFKB1 Antibodies) signaling by CD40L and TNF (show TNF Antibodies) in endoth...

7. CD40L, more than IL-6 (show IL6 Antibodies), or TNF-alpha (show TNF Antibodies), constitutes a predictor to explain polycystic ovary syndrome and associated features

8. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis.

9. Plasma sCD40L levels were elevated in systemic lupus erythematosis patients who had positive anti-phospholipid antibodies and experienced arterial thrombosis, suggesting that enhanced release of sCD40L through platelet activation presumably by aPL (show FASL Antibodies) could contribute to the development of atherothrombotic disease.

10. Higher concentrations of CD40L in patients with limited cutaneous form in our study might suggest a role for CD40 (show CD40 Antibodies)/CD40L pathway in vascular pathology of systemic sclerosis.

Mouse (Murine) CD40 Ligand (CD40LG) interaction partners

1. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.

2. Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis.

3. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 (show GLI2 Antibodies) in the tumor microenvironment downstream of CCR3 (show CCR3 Antibodies) signaling

4. our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8 (show CD8A Antibodies)(+) T-cell responses also under inflammatory conditions, CD40L expression by CD8 (show CD8A Antibodies)(+) T cells themselves is dispensable in acute lymphocytic choriomeningitis virus infection.

5. Platelets promote allergic asthma through the expression of CD154.

6. CD40L does not play a functional role in experimental acute pancreatitis

7. The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes.

8. there is a major involvement of the CD40 (show CD40 Antibodies)-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.

9. Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.

10. although treated CD40 (show CD40 Antibodies) knockout mice remained healed, developed long-term immunity, and were resistant to secondary Leishmania major challenge, treated CD40L knockout reactivated their lesion after cessation of rIL (show PDLIM4 Antibodies)-12 treatment.

Pig (Porcine) CD40 Ligand (CD40LG) interaction partners

1. CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells

Cow (Bovine) CD40 Ligand (CD40LG) interaction partners

1. Results demonstrated greater CD40 (show CD40 Antibodies) and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.

Rhesus Monkey CD40 Ligand (CD40LG) interaction partners

1. Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.