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that the rs3765459 variant in CD40 gene is associated with susceptibility to neuromyelitis optica spectrum disorders.
We disclosed the association of different CD40 SNPs with Graves disease and Hashimoto's Thyroiditis susceptibility in Chinese patients. This suggests that there might be several different susceptibility loci for autoimmune thyroid diseases (AITD) within CD40, each contributing a different effect in the onset and development of AITDs.
CD40 gene rs4810485 and rs1883832 mutations investigated in Recurrent aphthous stomatitis patients.
these data demonstrated that miR (show MLXIP Proteins)-145-5p may function as a cardiac-protective molecule in myocardial ischemic injury by ameliorating inflammation and apoptosis via negative regulation of CD40.
rs4810485 G>T and rs1883832 C >T SNPs in the CD40 gene may be associated with disease susceptibility and severity in knee osteoarthritis in the Chinese Han population.
Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B (show IL1B Proteins) rs16944, IL1R2 (show IL1R2 Proteins) rs2071008, PLA2G7 (show Lp-PLA2 Proteins) rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 (show CD36 Proteins) rs2065666 were associated with coronary heart disease (CHD (show CHDH Proteins)), suggesting an important role of inflammation in the risk of CHD (show CHDH Proteins).
miR (show MLXIP Proteins)-145 is involved in the anti-proliferation and anti-inflammation effects of aspirin on vascular smooth muscle cells by inhibiting the expression of CD40.
selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 (show STAT1 Proteins) expression and NF-kappaB (show NFKB1 Proteins) activity.
CD40 signaling in adipose tissue macrophages regulates major histocompatibility complex class II and CD86 (show CD86 Proteins) expression to control the expansion of CD4 (show CD4 Proteins)(+) T cells.
CD40 activation resulted in down-regulation of Thioredoxin (Trx)-1 (show TXN Proteins) to permit ASK1 (show MAP3K5 Proteins) activation and apoptosis. Although soluble receptor (show IFNAR1 Proteins) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 agonist and pharmacological inhibition of Trx-1 (show MLL Proteins) was functionally equivalent to the signal triggered by mCD40L.
Results suggest that platelet CD40 plays a pivotal role in neointima formation after arterial injury
CD73 expression identifies a subset of IgM (show CD40LG Proteins)(+) antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent
CD40 silencing with a specific siRNA ameliorates progression of experimental atherosclerosis in ApoE (show APOE Proteins)(-/-) mice via NF-kappaB (show NFKB1 Proteins)/miR (show MLXIP Proteins)-125b signaling axis.
CD40 functions as a non-redundant mechanism to convert the tumor microenvironment immunologically.
CD40 plays a critical role in the pathogenesis of type 1 diabetes, influencing lymphocyte trafficking, T-cell receptor expression, and T-cell pathogenesis.
Adoptively transferred Th40 cells (CD4 (show CD4 Proteins)+CD40+ Tcells) are present in lesions in the CNS and are associated with wide spread demyelination.
this study reports that anti-CD40 mAb administration <3 d in advance of chemotherapy is lethal in more than half of treated C57BL/6 mice in pancreatic cancer model
The data show that CD40-mediated inhibition of PC generation is via engagement of multiple pathway and constitutive CD40 signaling in vivo involving bystander T-B interactions can calibrate B cell differentiation outcomes
These results therefore may help understand the molecular mechanism of CD40L (show CD40LG Proteins) signaling that contributes to the pathophysiology of atherosclerosis.
This study shows that xenogeneic interaction between hCD40L and pCD40 can activate porcine endothelial cells through NF-kappaB (show NFKB1 Proteins) signaling.
The appearance of CD25 (show IL2RA Proteins) after activation of porcine dendritic cells, is reported.
Results demonstrated greater CD40 and CD40L (show CD40LG Proteins) expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.
study investigated the hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis-infected macrophages
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
B cell surface antigen CD40
, B cell-associated molecule
, B-cell surface antigen CD40
, CD40 antigen (TNF receptor superfamily member 5)
, CD40 type II isoform
, CD40L receptor
, nerve growth factor receptor-related B-lymphocyte activation molecule
, tumor necrosis factor receptor superfamily member 5
, tumor necrosis factor receptor superfamily, member 5
, T-cell differentiation antigen
, human CD40-homologue
, CD40 antigen, TNF receptor superfamily member 5