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anti-Human EGFR Antibodies:
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Human Polyclonal EGFR Primary Antibody for IHC, WB - ABIN6713327
Li, Sun, Fang, Han, Luo, Wang, Pan, Hu, Zhang, Pao, Shen, Ji, Chen: Lung adenocarcinomas with HER2-activating mutations are associated with distinct clinical features and HER2/EGFR copy number gains. in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012
Show all 10 Pubmed References
Human Polyclonal EGFR Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899925
Sarup, Jin, Turin, Bai, Beryt, Brdlik, Higaki, Jorgensen, Lau, Lindley, Liu, Ni, Rozzelle, Kumari, Watson, Zhang, Shepard: Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. in Molecular cancer therapeutics 2008
Show all 8 Pubmed References
Human Polyclonal EGFR Primary Antibody for WB - ABIN1881287
Zanardi, Yei, Lichtenstein, Tollefson, Wold: Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor. in Journal of virology 2003
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Human Polyclonal EGFR Primary Antibody for WB - ABIN3042517
Ge, Yu, Petitte, Zhang: Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1. in Biology of reproduction 2009
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Human Polyclonal EGFR Primary Antibody for DB, WB - ABIN1881284
Aifa, Aydin, Nordvall, Lundström, Svensson, Hermanson: A basic peptide within the juxtamembrane region is required for EGF receptor dimerization. in Experimental cell research 2004
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Human Polyclonal EGFR Primary Antibody for DB, WB - ABIN1881285
Adams, McKern, Ward: Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor. in Growth factors (Chur, Switzerland) 2004
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Human Polyclonal EGFR Primary Antibody for DB, WB - ABIN1881286
Ichinose, Murata, Yanagida, Sako: EGF signalling amplification induced by dynamic clustering of EGFR. in Biochemical and biophysical research communications 2004
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Human Polyclonal EGFR Primary Antibody for DB, WB - ABIN1881283
Kuribayashi, Kataoka, Kurabayashi, Miura: Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells. in Endocrinology 2004
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Human Polyclonal EGFR Primary Antibody for DB, WB - ABIN1944845
Kapoor, Zhan, Johnson, ORourke: Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells. in Molecular and cellular biology 2003
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Human Polyclonal EGFR Primary Antibody for WB - ABIN2801937
Ilekis, Stark, Scoccia: Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta. in Molecular reproduction and development 1995
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Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2).
In segmentation mutants, where specific peaks of EGFR ligands fail to form, gaps in signaling activity appear, leading to coincident hid up-regulation and subsequent cell death. In wild-type embryos, the segmentation cascade elicits the segmental production of several epidermal growth factor receptor (EGFR) ligands, including the transforming growth factor Spitz (TGFalpha), and the neuregulin, Vein.
In this study, whole genome expression analysis was performed to identify genes activated by JAK/STAT and/or EGFR..AdamTS-A mRNA becomes enriched at the anterior and posterior poles of the egg chamber at stages 6 to 7 and is regulated by JAK/STAT.
Wnt signaling functions genetically upstream of EGFR signaling by activating the expression of the EGFR ligand, Spitz.
The somatic EGFR-ERK activity appeared to regulate the termination of Bam expression in the germline and promote subsequent differentiation to the spermatocyte stage.
stress-dependent EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/Pi3K/TOR signaling.
EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
Graf functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro is antagonized by EGFR signaling, which inhibits Gro-dependent repression via p-ERK mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT/ERK pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Data suggest that OSCP1 (organic solute carrier partner 1) plays multiple roles during eye development in D. melanogaster; OSCP1 regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.
The vector of cell movement is regulated by localised epidermal growth factor (EGF) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.
Our findings provide in vivo evidence for the role of adult neurons in the maintenance of glia and a novel role for EGFR signaling in the autophagic flux.
Gro inhibits rho expression in undifferentiated cells and represses the expression of both ato and rho in non-R8 precursors during initiation of photoreceptor differentiation in an E(spl)-dependent manner.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance.
Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
Compared with common EGFR mutation, uncommon EGFR mutations in patients with nonsmall-cell lung cancer were associated with a modest sensitivity to EGFR tyrosine kinase inhibitors
The A allele in rs2159359 SNP in NME1 and the G allele in rs13222385 in EGFR were associated with worse overall survival in endometrial cancer. Both exhibited genome wide significance; rs13222385 remained significant after adjusting for prognostic clinical variables.
The natural history of EGFR mutant.
Detection of the gene status of EGFR, ROS1, and MET will facilitate screening more NSCL adenocarcinoma patients who might benefit from targeted therapy.
Silencing Rubcn, preventing EGFR activity or directly inducing autophagy in retinal pigment epithelial cells by starvation inhibits phagocytic degradation of photoreceptor outer segments.
Knockdown of YB1 expression in different colon cancer cell lines decreased cell proliferation and migration regardless of the status of RAS/RAF. In contrast, YB1 knockdown altered the expression of apoptosisrelated genes and the expression of EGFR was detected in the cell lines expressing wildtype RAS/RAF but not in those expressing mutated RAS/RAF.
this study shows a high concordance rate between EGFR mutations identified using primary tumor tissue and corresponding pleural effusion samples in non-small cell lung cancer
EGFR amplification had associated with poor prognosis in early, well to moderately differentiated carcinoma
NIH3T3 transfected with EGFR-PPARGC1A as well as A431 showed increased cell proliferation activity. With regard to underlying mechanism, EGFR-PPARGC1A protein causes constitutive tyrosine phosphorylation, and induces the phosphorylation of wild-type full-length epidermal growth factor receptor (EGFR) by dimerization.
an increased EGFR gene copy number in surgically resected non-adenocarcinoma of non-small cell lung cancer was associated with worse survival
Only modest improvement in response to HS-173 with reversible EGFR inhibitor gefitinib.
only tumors expressing both EGFR and c-Fos responded to anti-EGFR therapy
This is the first study to demonstrate the expression of EGFR protein in CTCs from sarcoma patients.
These results suggest that a phosphorylated EGFR dimer loaded with core signaling adapters is not sufficient to activate Ras.
Our analysis demonstrates that EGFR-TKIs confer significant PFS and OS benefits in the real-world practice for Korean female with advanced lung cancer
This meta-analysis suggests that EGFR mutation can be a risk factor for brain metastases in non-small cell lung cancer
Findings show that EGFR-TKI treatment facilitates gene resistant-mutation and the emergence of EGFR T790M secondary mutation by the attenuation of BER via induction of HSP70 protein degradation in non-small cell lung cancer.
Results show that EGFR expression is regulated by Circ-ATP8A2 through sponging miR-433 in cervical cancer.
Results show high expression level of EGFR protein in myeloma tissues from relapsed patients.
this study not only advances our understanding of how IL-36 cytokines may control mucosal inflammation, but also establishes EGFR signaling as a potentially important modulator of IL-36 cytokine function
ADAM17 is needed for EGF-R-mediated induction of IL-6 synthesis, which via IL-6 trans-signaling induces beta-catenin-dependent tumorigenesis.
Low EGFR expression is associated with impaired neural stem cell expansion and hypersensitivity leading to epileptic seizures.
G protein-coupled receptor family C group 5 member A (GPRC5A) deficiency contributes to dysregulated proto-oncogene protein c-mdm2 (MDM2) via activated epidermal growth factor receptor (EGFR) signaling, which promotes lung tumor development.
These findings define a novel mechanism that integrates EGFR and Wnt/beta-catenin pathways to coordinate the delicate balance between proliferation and differentiation during development.
The results identify a novel mechanism of TRAF4-mediated EGFR activation and signaling.
Rotational dynamics of the epidermal growth factor receptor.
Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling
High EGFR expression is associated with angiogenesis in B16 melanoma.
Chi3l3 activates EGFR to promote oligodendrogenesis.
Gene deletion of Egfr in myeloid cells limits IL-6 and TNF-alpha production, lipid uptake, and consecutively reduces atherosclerosis development.
Our results identify a key role for NRG1/ErbB signalling in the regulation of hippocampal mGluRI-dependent synaptic and cognitive functions, whose alteration might contribute to the pathogenesis of different brain diseases.
Amphiregulin plays an important role in promoting cardiac fibrosis after myocardial infarction partly though activating the EGFR pathway.
We further show that EGFR is activated through toll-like receptor 4. Disruption of toll-like receptor 4 or the EGFR pathway led to reduced inflammatory activity and foam cell formation
HER2 and HER3 expression was detected in 22.2% and 86.1% of samples, respectively. The frequency of EGFR mutation was 45.7% and was not significantly different between stage 0 and IA1 (40.0% and 48.0%, respectively), suggesting that EGFR mutation does not correlate with cancer progression from stage 0 to IA1.
The results indicate that EGFR and its activation are critical for YAP-mediated suppression of TGF-beta1-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1-mediated simultaneous apoptosis and epithelial mesenchymal transformation.
our findings suggested the concept of the EGFR activated Osteoarthritis (OA) subpopulation and illustrated the mechanism of EGFR signaling in regulating cartilage homeostasis. Gefitinib could be a promising disease-modifying drug for this OA subpopulation treatment.
Cortactin expression in carcinoma cells and its known involvement in the EGFR pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
results suggest ADAM17/EGFR-driven PLCgamma1 and PKC pathways as important promoters of TG1 expression during terminal keratinocyte differentiation.
These results show that EGFR is a co-factor of Transmissible gastroenteritis virus (TGEV), and that it plays a synergistic role with Aminopeptidase N early in TGEV infection.
this study shows that anemonin may ameliorate LPS-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS-derived nitric oxide.
An expressed transition SNP was identified in Meishan and white composite swine breeds.
EGFR, VEGFR and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF and its receptor on the uterine artery and the region supplying these vessels.
This result suggests that ubiquitination of the kinase-impaired receptor can mediate its internalization by the clathrin pathway.
A linear relationship of EGF/EGFR, PI3-kinase, MAPK and geminal vesicle breakdown, presents a relatively definitive mechanism of EGF-induced meiotic resumption of porcine oocyte.
mRNA expression of EGF receptor
EGFR activation, by PKC signal pathway, participates in FSH-induced porcine oocyte meiotic resumption.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (human recombinant EGF) alone or with EGF in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src and PI3K to amplify the oxytocin signaling to increase the output of PGF(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF and HGF pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
These results show that MMP-2 activates the EGFR and triggers downstream signaling pathways increasing Reactive Oxygen Species formation and promoting vasoconstriction.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1