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Human EGFR Protein expressed in HEK-293 Cells - ABIN2180999
Fazekas-Singer, Berroterán-Infante, Rami-Mark, Dumanic, Matz, Willmann, Andreae, Singer, Wadsak, Mitterhauser, Jensen-Jarolim: Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials. in Oncotarget 2017
Human EGFR Protein expressed in Human Cells - ABIN2001843
Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000
Show all 4 Pubmed References
Human EGFR Protein expressed in Wheat germ - ABIN1352437
Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013
Human EGFR Protein expressed in HEK-293 Cells - ABIN5674594
Yu, Pegram, Bigner, Chandramohan: Development and validation of a cell-based fluorescent method for measuring antibody affinity. in Journal of immunological methods 2017
Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000
Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014
Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019
Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. in British journal of cancer 2014
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (show ERBB2 Proteins)).
Graf (show ARHGAP26 Proteins) functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (show CXCL1 Proteins) is antagonized by EGFR signaling, which inhibits Gro (show CXCL1 Proteins)-dependent repression via p-ERK (show MAPK1 Proteins) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (show STAM Proteins) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (show TGFb Proteins) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (show MAPK8 Proteins) signaling
Loss of Usp5 (show USP5 Proteins) results in upregulation of Notch (show NOTCH1 Proteins) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (show AKT1 Proteins)/ERK (show MAPK1 Proteins) pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB (show NFKB1 Proteins) inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta (show LTB Proteins) interaction reverses resistance.
Study demonstrated that IGF-I (show IGF1 Proteins) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 (show PGRMC1 Proteins) signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper (show GPER Proteins).
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
Subsequent experiments documented that activation of EGFR signaling induced by PD98059 increased the amount of beta-catenin (show CTNNB1 Proteins) in the nucleus. Taken together, our findings may elucidate a possible mechanism explaining the ineffectiveness of MEK (show MAP2K1 Proteins) inhibitors in breast cancer treatment and improve our understanding of the role of MEK (show MAP2K1 Proteins) in cancer
Among 718 patients with newly diagnosed metastasised non-squamous NSCLC, 11% (51/447) harboured an EGFR mutation in the exons 18, 19 or 21.
EGFR expression stratified most pronounced among HSP90low tumours, where the EGFRhigh phenotype was associated with longer survival
The level of EGFR amplification and overexpression significantly predicted response and survival benefit, particularly the mRNA and protein expression level. A combination of mRNA and protein expression may predict efficacy of cetuximab more efficiently.
variants of EGFR and SYNE2 (show SYNE2 Proteins) play an important role in p21 (show CDKN1A Proteins) regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53 (show TP53 Proteins)-indenpdent manner
Overexpression of EGFR and MMP-2 (show MMP2 Proteins) plays an essential role in the initiation and progression of non-small-cell lung carcinoma.
EGFR amplification and EGFRvIII mutation is associated with glioblastoma.
These findings suggest that increased JUN (show JUN Proteins) expression and activity may contribute to gefitinib resistance in non-small cell lung cancer.
These data further establish a regulatory network where co-activation of Toll (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) and EGFR signaling by reactive oxygen species levels in the posterior signaling center niche controls lymph gland hematopoiesis under parasitism.
The dipole potential exerts significant effects on the ligand binding, clustering and signaling of ErbB1 protein.
Suggest caution for the proposed therapeutic strategy of combined signal transducer and activator of transcription (show STAT1 Proteins)/epidermal growth factor receptor inhibition for cancer treatment with respect to cardiotoxity.
Stress-specific p38 MAPK (show MAPK14 Proteins) activation is sufficient to drive EGFR endocytosis but not its nuclear translocation.
miR (show MLXIP Proteins)-145 can decrease MUC5AC expression by inhibiting EGFR and alleviating airway remodeling. This indicates that miR (show MLXIP Proteins)-145 may be used as a molecular predictor for airway remodeling.
To evaluate the role of EGFR signaling in the articular cartilage, we studied a cartilage-specific Egfr-deficient (CKO) mouse model (Col2-Cre EgfrWa5/flox). These mice developed early cartilage degeneration at 6 mo of age. By 2 mo of age, although their gross cartilage morphology appears normal, CKO mice had a drastically reduced number of superficial chondrocytes and decreased lubricant secretion at the surface.
All these findings suggest that EGCG can resist skin senility effectively. And the EGFR with relate of downstream proteins are implicated in the skin aging.
Using a murine model for glioblastoma driven by a single genetic driver, the study suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness.
These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations.
These results collectively suggest that sustained activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling.
Epidermal growth factor receptor (EGFR) signaling enhances miR (show MLXIP Proteins)-29 expression in glioblastoma cells via upregulation of Sterol regulatory element binding protein 1 (show SREBF1 Proteins)
YAP (show YAP1 Proteins) accumulated in nuclei of mammary glands in ErbB2 (show ERBB2 Proteins)/EGFR-transgenic mice, suggesting that EGFR signaling affects YAP (show YAP1 Proteins) in vivo similar to cell culture. ErbB2 (show ERBB2 Proteins)/EGFR-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (show SDC4 Proteins) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (show EGF Proteins) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (show NOS1 Proteins)-derived nitric oxide.
EGFR, VEGFR (show KDR Proteins) and FGFR (show FGFR2 Proteins) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (show EGF Proteins) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (show EGF Proteins) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (show EGF Proteins) (human recombinant EGF (show EGF Proteins)) alone or with EGF (show EGF Proteins) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (show EGF Proteins) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (show SRC Proteins) and PI3K to amplify the oxytocin signaling to increase the output of PGF (show PGF Proteins)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (show EGF Proteins)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (show EGF Proteins)) and EGF (show EGF Proteins) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (show MMP14 Proteins) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (show EGF Proteins) and HGF (show HGF Proteins) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1