Browse our anti-IKBKG (IKBKG) Antibodies

Full name:: anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma Antibodies (IKBKG)

On www.antibodies-online.com are 333 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Antibodies from 33 different suppliers available. Additionally we are shipping IKBKG Kits (19) and IKBKG Proteins (11) and many more products for this protein. A total of 381 IKBKG products are currently listed.

Synonyms:: 1110037D23Rik, AI848108, AI851264, AMCBX1, AW124339, CG16910, dIKK, dIKK-gamma, Dmel\\CG16910, DmIKK-gamma, dmIKKgamma, FIP-3, FIP3, Fip3p, fj33c07, IKBKG, IKBKG_1, IKBKG_2, IKK, IKK-gamma, IKKg, IKKgamma, IKK[g], IKK[[gamma]], IP, IP1, IP2, IPD2, Kenny, Key, MGC97885, nemo, wu:fj33c07, ZC2HC9, zgc:113492

list all antibodies	Gene Name	GeneID	UniProt
	IKBKG	8517	Q9Y6K9
	IKBKG	16151	O88522
	IKBKG	309295	Q6TMG5
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Most Popular Reactivities for anti-IKBKG (IKBKG) Antibodies

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anti-Human IKBKG Antibodies:

anti-Mouse (Murine) IKBKG Antibodies:

anti-Rat (Rattus) IKBKG Antibodies:

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Relevant Pathways for anti-IKBKG Antibodies

Toll-Like Receptors Cascades

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Top referenced anti-IKBKG Antibodies

Human Monoclonal IKBKG Primary Antibody for SimWes, WB - ABIN252501 : Wunderlich, Luedde, Singer, Schmidt-Supprian, Baumgartl, Schirmacher, Pasparakis, Brüning: Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
Show all 7 Pubmed References
Human Monoclonal IKBKG Primary Antibody for ICS - ABIN1177069 : Carter, Pennington, Ungurait, Ballard: In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase. in The Journal of biological chemistry 2003 (PubMed)
Show all 6 Pubmed References
Human Monoclonal IKBKG Primary Antibody for FACS, WB - ABIN252492 : Harhaj, Sun: IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. in The Journal of biological chemistry 1999 (PubMed)
Show all 5 Pubmed References
Human Monoclonal IKBKG Primary Antibody for ELISA - ABIN4324315 : Han, Karabiyikoglu, Kelly, Sobel, Yenari: Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003 (PubMed)
Show all 5 Pubmed References
Human Polyclonal IKBKG Primary Antibody for ICC, ELISA - ABIN1002508 : Li, Kang, Friedman, Tarassishin, Ye, Kovalenko, Wallach, Horwitz: Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
Show all 4 Pubmed References
Human Monoclonal IKBKG Primary Antibody for WB - ABIN387828 : Mooster, Cancrini, Simonetti, Rossi, Di Matteo, Romiti, Di Cesare, Notarangelo, Geha, McDonald: Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. in The Journal of allergy and clinical immunology 2010 (PubMed)
Show all 6 Pubmed References
Human Polyclonal IKBKG Primary Antibody for ELISA, ICC - ABIN4324313 : Sadaka, Marloie-Provost, Soumelis, Benaroch: Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells. in Blood 2009 (PubMed)

More Antibodies against IKBKG Interaction Partners

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

Computational analysis identified two miR (show MLXIP Antibodies)-107 binding sites in the 3'UTR (show UTS2R Antibodies) of IKBKG suggesting that IKBKG expression is regulated by miR (show MLXIP Antibodies)-107.
Human IKKgamma does not interact with mammalian Atg8-family proteins.
Data suggest the angiopoietin-like 8 (ANGPTL8)/p62 (show GTF2H1 Antibodies)-IKKgamma axis as a negative feedback loop that regulates NF-kappaB (show NFKB1 Antibodies) activation, and extends the role of selective autophagy in fine-tuned inflammatory responses.
this study demonstrates immunodeficiency in two female patients with Incontinentia Pigmenti with heterozygous NEMO mutation diagnosed by lipopolysaccharide unresponsiveness
GSK-3beta is critically important for ordered NF-kappaB (show NFKB1 Antibodies) signalling through modulation of NEMO phosphorylation.
HOTAIR operates the action of IKKalpha (show CHUK Antibodies), IKKbeta (show IKBKB Antibodies), IKKgamma in liver cancer stem cells
the present study found that loss of the NEMO-SHARPIN (show SHARPIN Antibodies) interaction impaired recruitment of truncated NEMO forms into punctuate structures that are transiently formed on cell stimulation and thus led to a defect in linear ubiquitination
NEMO was critically involved in the cGAS-STING pathway.
Results show that NEMO's expression is regulated by ASAP3 (show ASAP3 Antibodies) which it interacts directly with it reducing its poly-ubiquitinylation.
E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

NEMO deficiency hampered activation of IKK (show CHUK Antibodies) complex in osteoclast precursors, causing arrest of osteoclastogenesis and apoptosis. Interestingly, inhibiting apoptosis by genetic ablation of TNFr1 (show TNFRSF1A Antibodies) significantly increased cell survival, but failed to rescue osteoclastogenesis or reverse osteopetrosis (show CSF1 Antibodies).
NEMO was critically involved in the cGAS-STING pathway.
This study provides evidence for a protective function of canonical IKK (show CHUK Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling in the arenchymal compartment during pancreatitis. In the absence of the regulatory IKK (show CHUK Antibodies) subunit NEMO, a combination of a fibrogenic gene signature, enhanced acinar-ductal metaplasia and a lack of regeneration contribute to the exacerbation of pancreatitis.
E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression.
robust caspase (show CASP3 Antibodies) activation in NEMO-deficient cells is concomitant with RIPK3 (show RIPK3 Antibodies) recruitment to the apoptosis-mediating complex.
lymphocyte-specific deletion of IKK2 (show IKBKB Antibodies) or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
Whereas Parkin (show PARK2 Antibodies) has been reported to positively regulate the expression of OPA1 (show MED12 Antibodies) through NEMO, herein we found that PARK2 (show PARK2 Antibodies) overexpression did not modify the expression of OPA1 (show MED12 Antibodies).
prevents colon inflammation by NF-kappaB (show NFKB1 Antibodies)-independent functions
Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.
SENP1 (show SENP1 Antibodies) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (show NFKB1 Antibodies) activity, cytokine production and pancreatic inflammation.

Fruit Fly (Drosophila melanogaster) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

Drosophila Kenny is a selective autophagy receptor that mediates the degradation of the IkappaB kinase (show CHUK Antibodies) complex. Selective autophagic degradation of the IkappaB kinase (show CHUK Antibodies) complex prevents constitutive activation of the immune deficiency pathway in response to commensal microbiota. We show that autophagy-deficient flies have a systemic innate immune response that promotes a hyperplasia phenotype in the midgut.

Pig (Porcine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

Porcine deltacoronavirus nsp5 (show SPECC1 Antibodies), the 3C-like protease, inhibits interferon-beta (show IFNB1 Antibodies) production through the cleavage of NEMO.
Nsp4 interfered with the NF-kappaB (show NFKB1 Antibodies) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (show IFNB1 Antibodies) production.
Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.

IKBKG Antigen Profile

Antigen Summary

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Alternative names and synonyms associated with IKBKG

inhibitor of nuclear factor kappa B kinase subunit gamma (IKBKG) antibody
inhibitor of kappaB kinase gamma (Ikbkg) antibody
inhibitor of nuclear factor kappa B kinase subunit gamma (Ikbkg) antibody
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (ikbkg) antibody
inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog (ikbkg.L) antibody
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG) antibody
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG_1) antibody
inhibitor of nuclear factor kappa B kinase subunit gamma (ikbkg) antibody
kenny (key) antibody

1110037D23Rik antibody
AI848108 antibody
AI851264 antibody
AMCBX1 antibody
AW124339 antibody
CG16910 antibody
dIKK antibody
dIKK-gamma antibody
Dmel\\CG16910 antibody
DmIKK-gamma antibody
dmIKKgamma antibody
FIP-3 antibody
FIP3 antibody
Fip3p antibody
fj33c07 antibody
IKBKG antibody
IKBKG_1 antibody
IKBKG_2 antibody
IKK antibody
IKK-gamma antibody
IKKg antibody
IKKgamma antibody
IKK[g] antibody
IKK[[gamma]] antibody
IP antibody
IP1 antibody
IP2 antibody
IPD2 antibody
Kenny antibody
Key antibody
MGC97885 antibody
nemo antibody
wu:fj33c07 antibody
ZC2HC9 antibody
zgc:113492 antibody

Protein level used designations for IKBKG

, , , , , , , , , , , , , , , , , , , , , , , , , I-kappa-B kinase subunit gamma IKKAP1 IKKG IkB kinase gamma subunit NF-kappa-B essential modifier NF-kappa-B essential modulator NFkappaB essential modulator ikB kinase subunit gamma ikB kinase-associated protein 1 incontinentia pigmenti inhibitor of nuclear factor kappa-B kinase subunit gamma IKK-gamma inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma mFIP-3 I-kappa-B kinase gamma NEMO NF-kappa B essential modulator inhibitor of kappaB kinase gamma ikky inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2 NF-kappa-B essential modulator-like CG16910-PA CG16910-PB key-PA key-PB

GENE ID	SPECIES
8517	Homo sapiens
16151	Mus musculus
281855	Bos taurus
309295	Rattus norvegicus
541530	Danio rerio
701237	Macaca mulatta
735069	Xenopus laevis
743415	Pan troglodytes
100137553	Papio anubis
100145270	Xenopus (Silurana) tropicalis
100328905	Oryctolagus cuniculus
100470223	Ailuropoda melanoleuca
37967	Drosophila melanogaster
612576	Canis lupus familiaris
100127355	Sus scrofa
100722308	Cavia porcellus
100058432	Equus caballus

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Show all anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Antibodies with Pubmed References