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anti-Human Insulin Antibodies:
anti-Mouse (Murine) Insulin Antibodies:
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Buffalo (Bubalus) Polyclonal Insulin Primary Antibody for IEM, ICC - ABIN617877
Tay, Wong: Insulin-like immunoreactivity in the monkey spinal cord. in Acta anatomica 1992
Show all 44 Pubmed References
Human Monoclonal Insulin Primary Antibody for IHC (p) - ABIN3043651
Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats. in Experimental biology and medicine (Maywood, N.J.) 2009
Show all 20 Pubmed References
Cow (Bovine) Monoclonal Insulin Primary Antibody for CyTOF, FACS - ABIN4900790
Cucak, Grunnet, Rosendahl: Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. in Journal of leukocyte biology 2014
Show all 6 Pubmed References
Human Polyclonal Insulin Primary Antibody for EIA, FACS - ABIN372838
Madsen, Knauf, Gotfredsen, Pilling, Sjögren, Andersen, Andersen, de Boer, Manova, Barlas, Vundavalli, Nyborg, Knudsen, Moelck, Fagin: GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. in Endocrinology 2012
Show all 3 Pubmed References
Cow (Bovine) Monoclonal Insulin Primary Antibody for FACS - ABIN4898619
Kalis, Bolmeson, Esguerra, Gupta, Edlund, Tormo-Badia, Speidel, Holmberg, Mayans, Khoo, Wendt, Eliasson, Cilio: Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. in PLoS ONE 2012
Show all 3 Pubmed References
Human Polyclonal Insulin Primary Antibody for IHC, IHC (p) - ABIN4326017
Lindskog, Asplund, Engkvist, Uhlen, Korsgren, Ponten: Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets. in Discovery medicine 2010
Show all 2 Pubmed References
Human Monoclonal Insulin Primary Antibody for ELISA (Capture), ELISA - ABIN617624
Back, Scheuner, Han, Song, Ribick, Wang, Gildersleeve, Pennathur, Kaufman: Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. in Cell metabolism 2009
Show all 2 Pubmed References
Human Monoclonal Insulin Primary Antibody for ELISA (Capture), ELISA - ABIN617623
Kojima, Fujimiya, Matsumura, Nakahara, Hara, Chan: Extrapancreatic insulin-producing cells in multiple organs in diabetes. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 2 Pubmed References
Data suggest that higher plasma levels of ceramide with saturated fatty acid are associated with higher fasting levels of insulin and insulin resistance; in contrast, higher levels of sphingomyelin with saturated fatty acid are associated with lower fasting insulin and insulin resistance; this study was conduced in American Indians in AZ, OK, SD, and ND.
in latent autoimmune diabetes in adults, higher leptin (show LEP Antibodies) secretion may exert a direct effect on beta cell function leading to more insulin sensitivity
Identify a novel proinsulin-associated locus and demonstrate that whilst proinsulin levels are associated with carotid intima media thickness measures, proinsulin per se is unlikely to have a causative effect on cIMT.
Data suggest that both a KATP channel-dependent triggering pathway (that induces a [Ca2 (show CA2 Antibodies)+]i rise in beta-cells) and an amplifying pathway (that augments the effect of Ca2 (show CA2 Antibodies)+ on exocytosis) are crucial for control of insulin secretion in human islets; these studies used cultured pancreatic islets from multiorgan donors exposed to a variety of pharmacological agents.
In the present study, the protein inhibitor of activated STAT (show STAT1 Antibodies) Y (PIASy (show PIAS4 Antibodies)) was identified as a novel Isl1 (show ISL1 Antibodies)-interacting protein. Furthermore, PIASy (show PIAS4 Antibodies) and Isl1 (show ISL1 Antibodies) upregulate insulin gene expression and insulin secretion in a dose-dependent manner by activating the insulin promoter.
Muscle-related indices positively correlated with C-peptide, which showed endogenous insulin reserve
Data suggest that corticosterone and cortisol suppress voltage-dependent Ca2+ channel function and Ca2+ fluxes in beta-cells; however, insulin secretion, maximal ATP/ADP responses to glucose, and beta-cell identity/differentiation are all unaffected by these glucocorticoids.
In long-standing models, glucose is viewed as a primary stimulator of insulin secretion; recent models postulate that glucose activates a cell-surface receptor, namely the glucose-sensing receptor, on insulin-secreting cells. [REVIEW]
Data suggest that beta-cell insulin secretory granules, unlike neuronal synaptic vesicles, exhibit biphasic secretory mechanism that requires additional distinct features in exocytosis; beta-cell insulin exocytotic events appear to be mediated by Munc18/SNARE (show NAPA Antibodies) protein complexes distinct from those involved in predocking/fusion of insulin secretory granules with plasma membrane. [REVIEW]
Data suggest that glucose-stimulated insulin secretion involves interplay between metabolic and cationic events involving small G-proteins; activation of these signaling proteins promotes cytoskeletal remodeling, transport and docking of insulin granules on the plasma membrane for exocytotic secretion of insulin. [REVIEW]
Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (show ATP1A1 Antibodies) activity and SFK signaling.
PTPLAD1 (show PTPLAD1 Antibodies) and AMPK (show PRKAA1 Antibodies) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (show ATIC Antibodies) later accumulates in the Golgi/endosome fraction.
Pdx-1 (show PDX1 Antibodies), MafA (show MAFA Antibodies) and NeuroD1 (show NEUROD1 Antibodies) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin system, TNFalpha (show TNF Antibodies) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (show PPARG Antibodies), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (show IGF1 Antibodies) levels are less easily modified.
insulin increased GCLc (show GCLC Antibodies) promoter activity, which required a prerequisite increase or decrease in medium glucose
The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer.
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (show LEP Antibodies)-NPY (show NPY Antibodies) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (show VMP1 Antibodies)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (show FRAP1 Antibodies) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
insulin supports early initiation of the mesodermal factor Brachyury (show TBX1 Antibodies) and the signalling molecules Wnt3a (show WNT3A Antibodies) and Wnt4 (show WNT4 Antibodies) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
Data (including data from studies in knockout mice) suggest that Ins2 is involved in impaired nociception/diabetic neuropathy; here, mice heterozygous for mutant Ins2 exhibit (a) significant loss of intra-epidermal nerve fibers, (b) markedly reduced responsiveness to heat in dorsal root ganglion neurons, and (c) mostly unchanged function of cold-sensitive neurons; such mice become diabetic soon after weaning.
In the present study, the mRNA expression of the two mouse insulin genes Ins1 and Ins2 was investigated in MIN6 cells treated with different concentrations of melatonin, and insulin secretion was detected under the same conditions. Following the overexpression or silencing of MTNR1B (show MTNR1B Antibodies), the activities of components of the MAPK (show MAPK1 Antibodies) signaling pathway
These results suggest that PABP (show EBP Antibodies) interacts with HuD (show ELAVL4 Antibodies) in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP (show EBP Antibodies) is acted upon by PDI (show PDIA3 Antibodies) resulting in stimulation of insulin translation.
Data (including data from studies using knockout mice) suggest that Ins1 and Ins2 are required for pancreatic beta-cell maturation; thus, Ins1 and Ins2 are needed for normal beta-cell development and for maintenance of normal beta-cell function.
cTAGE5 (show CTAGE5 Antibodies) deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin (show Actbeta Antibodies) activity, rather than hormonal dysregulation.
report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (show SOX2 Antibodies)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (show GHRL Antibodies) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (show GHSR Antibodies) in the central nervous system and partly involved in carbohydrate-glycogen (show GYS2 Antibodies) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.