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Human Integrin beta 2 Protein expressed in HEK-293 Cells - ABIN2713476
De Franceschi, Peuhu, Parsons, Rissanen, Vattulainen, Salmi, Ivaska, Pouwels: Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. in PLoS ONE 2015
actin engagement produces tension within the beta2 subunit to induce and stabilize an active integrin conformational state and that this requires intact talin and kindlin motifs.
on tumour-infiltrating T-lymphocytes, galectin prevents the formation of a functional secretory synapse by preventing optimal LFA-1 (show ITGAL Proteins) triggering
exploration of the underlying mechanism demonstrated that ICAM3 (show ICAM3 Proteins) not only binds to LFA-1 (show ITGAL Proteins) with its extracellular domain and structure protein ERM (show ETV5 Proteins) but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis).
vesicle-associated RhoB is a regulator of the Rab11 (show RAB11A Proteins)-mediated recycling of LFA-1 (show ITGAL Proteins) to the cell surface, an event that is necessary for T lymphocyte motility.
The ITGB2 variant rs2230531 was examined in an independent cohort of Tasmanian patients with hematologic malignancies (HM) to see if its presence correlated with chronic lymphocytic leukemia. The variant was found in several lymphoid and myeloid HMs (show CTSC Proteins), so if contributes to the risk of HM, it does so broadly across HM subtypes in this population.
Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a (show ITGA1 Proteins)/CD18) activation and binding with soluble/immobilized ICAM1 (show ICAM1 Proteins) (intercellular cell adhesion molecule 1 (show CADM1 Proteins)).
an integrated strategy of whole genome and transcriptome analysis enabled identification of LB-ITGB2-1 as HLA-B*15:01-restricted MiHAs encoded by an alternative transcript. The alternative ITGB2 transcript was shown to be expressed in leukemic cells of different origins.
Neutrophil rolling over E-selectin (show SELE Proteins) at precise shear stress transmits tension and catch-bond formation with L-selectin (show SELL Proteins) via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit
CD177 (show CD177 Proteins) signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration.
Extracellular ISG15 (show ISG15 Proteins) signals cytokine secretion through the LFA-1 (show ITGAL Proteins) integrin receptor (CD11a (show ITGAL Proteins)/CD18) in natural killer cells.
A modulatory role for the tumor beta2 subunit of the LFA-1 (show ITGAL Proteins) integrin in the metastatic progression of colorectal cancer to the liver by impaired activation of liver endothelium.
Data show CD18 is selectively required for T helper 2, but not T helper 1, homing and has a minimal influence on T-effector development.
Adhesive properties of the leukocyte integrin Mac-1 (show ITGAM Proteins) are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 (show ITGAM Proteins) modulates inflammatory gene expression in macrophages.
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
An intracellular pool of LFA-1 (show ITGAL Proteins) in naive CD8 (show CD8A Proteins)(+) T cells plays a key role in T cell activation and differentiation.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (show CA5A Proteins))1in membrane organization and beta2 integrin Lfa1 (show ITGAL Proteins) function in primary CD8 (show CD8A Proteins) T cells.
Coro1A (show CORO1A Proteins) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.
These results identify CD47 (show CD47 Proteins) as an important regulator of LFA-1 (show ITGAL Proteins) and VLA-4 integrin-adhesive functions in T cell proliferation.
Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (show SELL Proteins) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (show CA2 Proteins)+]i, diminished annexin V (show ANXA5 Proteins) expression on the cell surface, and decreased caspase 3 (show CASP3 Proteins) activity in lysates
The I-EGF (show EGF Proteins)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (show ORM1 Proteins) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (show POLG Proteins) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
CR3 (show ITGAM Proteins) plays a cardinal (show CARD8 Proteins) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (show ZP3 Proteins) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (show IRF6 Proteins) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.
Integrin CD11c (show ITGAX Proteins)/CD18 alpha-chain (show FCGRT Proteins) phosphorylation is functionally important.
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, complement receptor C3 beta-subunit
, complement receptor C3 subunit beta
, integrin beta chain, beta 2
, integrin beta-2
, leukocyte cell adhesion molecule CD18
, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
, Mac-1 beta
, lymphocyte function associated antigen 1
, macrophage antigen-1 beta
, CD18 subunit
, Leu-CAM receptor
, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
, integrin beta 2 subunit
, CD18 leukocyte adhesion molecule
, antigen CD18
, integrin beta-2 chain
, integrin beta 2
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)
, macrophage antigen 1 (mac-1) beta subunit)
, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
, Complement receptor C3 subunit beta
, Integrin beta-2
, integrin beta-2 subunit
, integrin subunit beta 2 S homeolog
, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)