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anti-Mouse (Murine) NFKBIA Antibodies:
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Human Monoclonal NFKBIA Primary Antibody for CyTOF, FACS - ABIN252471
Saccani, Pantano, Natoli: p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. in Nature immunology 2001
Show all 33 Pubmed References
Human Polyclonal NFKBIA Primary Antibody for IF (p), IHC (p) - ABIN674454
Jiang, Tian, Fu, Zhu, Hou: Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model of cerebral ischemia and reperfusion injury. in European journal of pharmacology 2010
Show all 12 Pubmed References
Cow (Bovine) Monoclonal NFKBIA Primary Antibody for IP, WB - ABIN252664
Shakibaei, Allaway, Nebrich, Mobasheri: Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. in Evidence-based complementary and alternative medicine : eCAM 2012
Show all 11 Pubmed References
Human Monoclonal NFKBIA Primary Antibody for ELISA - ABIN4224345
Saccani, Pantano, Natoli: Two waves of nuclear factor kappaB recruitment to target promoters. in The Journal of experimental medicine 2001
Show all 10 Pubmed References
Human Polyclonal NFKBIA Primary Antibody for IF (p), IHC (p) - ABIN710696
Yan, Wu, Li, Meng, Dai, Zheng, Fu: Cyanidin-3-O-glucoside Induces Apoptosis and Inhibits Migration of Tumor Necrosis Factor-?-Treated Rat Aortic Smooth Muscle Cells. in Cardiovascular toxicology 2015
Show all 7 Pubmed References
Human Monoclonal NFKBIA Primary Antibody for IP, WB - ABIN967353
Baldwin: The NF-kappa B and I kappa B proteins: new discoveries and insights. in Annual review of immunology 1996
Show all 6 Pubmed References
Human Monoclonal NFKBIA Primary Antibody for IP, WB - ABIN531958
Strozyk, Pöppelmann, Schwarz, Kulms: Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. in Oncogene 2006
Show all 6 Pubmed References
Human Monoclonal NFKBIA Primary Antibody for WB - ABIN2668625
Syeda, Grosjean, Houliston, Keogh, Carter, Paleolog, Wheeler-Jones: Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways. in The Journal of biological chemistry 2006
Show all 6 Pubmed References
Human Monoclonal NFKBIA Primary Antibody for IF, IP - ABIN968112
Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995
Show all 5 Pubmed References
Human Monoclonal NFKBIA Primary Antibody for IF, IP - ABIN968113
Cordle, Donald, Read, Hawiger: Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells. in The Journal of biological chemistry 1993
Show all 5 Pubmed References
Combined computational and biochemical studies indicated that the extent of NF-kappaB (show NFKB1 Antibodies)-responsive expression of Nfkbia, which encodes IkappaBalpha, inversely correlated with cross-talk. The Nfkbia promoter showed enhanced responsiveness to NF-kappaB (show NFKB1 Antibodies) activation in macrophages compared to that in fibroblasts
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB (show NFKB1 Antibodies)(p65 (show NFkBP65 Antibodies)), miR (show MLXIP Antibodies)-196b-3p, Meis2 (show MEIS2 Antibodies), and PPP3CC (show PPP3CC Antibodies) is formed during the emergence of castration-resistant prostate cancer.
Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
SM22alpha (show TAGLN Antibodies) is a phosphorylation-regulated (show PHAX Antibodies) suppressor of IKK (show CHUK Antibodies)-IkappaBalpha-NF-kappaB (show NFKB1 Antibodies) signaling cascades.
We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Antibodies), Nfkbia and Pdyn (show PDYN Antibodies), and different aspects of susceptibility to stress.
Specific and constitutive deletion of the inhibitor of NF-kappaB (show NFKB1 Antibodies) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection
GRK6 (show GRK6 Antibodies) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (show GRK6 Antibodies) suppresses TNF-alpha (show TNF Antibodies)-induced NF-kappaappaB signaling.
Results demonstrate novel roles of TNFRII (show TNFRSF1B Antibodies) in the regulation of Abeta (show APP Antibodies) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (show TNFRSF1B Antibodies) levels and elevating phosphorylated IkappaBalpha by SUMOylation.
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.
Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (show NFKB1 Antibodies) inhibitor beta (IkappaBbeta (show NFKBIB Antibodies)), cleaving them in a mouse hemorrhage model.
miR (show MLXIP Antibodies)-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB (show NFKB1 Antibodies) pathway and thus increased the radioresistance of breast cancer cells.
We showed that pristimerin suppressed tumor necrosis factor a (TNFalpha)-induced IkappaBa phosphorylation, translocation of p65, and expression of NFkappaB-dependent genes. Moreover, pristimerin decreased cell viability and clonogenic ability of Uveal melanoma (UM)cells. A synergistic effect was observed in the treatment of pristimerin combined with vinblastine, a frontline therapeutic agent, in UM.
Data collectively demonstrate the functional importance of IkappaBalpha-mediated stripping of NFkappaB from DNA in the kinetic control of NFkappaB signaling.
These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR (show MLXIP Antibodies)-146a rs2910164 and pre-miR (show MLXIP Antibodies)-499 rs3746444 may represent novel markers of AT susceptibility.
XPO1 (show XPO1 Antibodies) inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IkappaBalpha and overcomes acquired proteasome inhibitor resistance in human multiple myeloma.
Molecular docking analysis indicated that transcription factor NF-kappaB (show NFKB1 Antibodies) was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFalpha (show TNF Antibodies)-induced phosphorylation of upstream IkappaBalpha kinase in a time-dependent manner leading to the suppression of NF-kappaB (show NFKB1 Antibodies) activation and nuclear translocation
FBXO32 (show FBXO32 Antibodies) activates NF-kappaB (show NFKB1 Antibodies) through IkappaBalpha degradation in inflammatory and genotoxic stress
The results showed that NFKB1 (show NFKB1 Antibodies) and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB (show NFKB1 Antibodies) have been described.
Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (show NFKB1 Antibodies) (RelA (show NFkBP65 Antibodies)-p50 (show CD40 Antibodies)) heterodimer induced by DNA or IkappaBalpha binding.
IkappaB-alpha protein was stabilized by COMMD1 (show COMMD1 Antibodies), which attenuated NF-kappaB (show NFKB1 Antibodies) signaling during Toll (show TLR4 Antibodies)-like receptor ligand and tumor necrosis factor alpha (show TNF Antibodies) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
NFKBIA has a role as a marker of NF-kappaB (show NFKB1 Antibodies)/p65 (show SYT1 Antibodies) activation in the early embryo.
NF-kappaB (show NFKB1 Antibodies) has a role in increasing PDGF-B (show PDGFB Antibodies) transcription
AIP1 (show PDCD6IP Antibodies) is a novel transducer in TNF (show TNF Antibodies)-induced TRAF2 (show TRAF2 Antibodies)-dependent activation of ASK1 (show MAP3K5 Antibodies) that mediates a balance between JNK (show MAPK8 Antibodies) versus NF-kappaB (show NFKB1 Antibodies) signaling
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
NF-kappa-B inhibitor alpha
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light polyp gene enhancer in B-cell 1
, major histocompatibility complex enhancer-binding protein MAD3
, nuclear factor of kappa light chain gene enhancer in B-cells
, I kappa B-alpha
, NF-kappaB inhibitor alpha
, REL-associated protein pp40
, Rel-associated pp40
, IkappaB alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha