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anti-Mouse (Murine) NFKBIB Antibodies:
anti-Human NFKBIB Antibodies:
anti-Rat (Rattus) NFKBIB Antibodies:
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Human Monoclonal NFKBIB Primary Antibody for ELISA, WB - ABIN969314
Chen, Vallee, Wu, Vu, Sondek, Ghosh: Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. in Molecular and cellular biology 2004
Show all 3 Pubmed References
IkappaBbeta has essential functions within the Rel-NFkappaB generation module, specifically for the RelA:RelA homodimer, which controls a subset of NFkappaB target genes.
these results mechanistically link the innate immune response mediated by IkappaBbeta/NF-kappaB to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.
Dengue virus protease interacts with both IkappaBalpha and IkappaBbeta cleaving them in a mouse hemorrhage model.
sustained NF-kappaB activity mediated by IkappaBbeta protects against hyperoxic lung injury through increased expression of antiapoptotic genes
Findings represent a necessary but not sufficient role of IkappaBbeta in preventing oxidant stress-induced cell death.
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
IkappaBbeta acts through p65:c-Rel dimers to maintain prolonged expression of TNF-alpha
data suggest that RelA is liberated during LPS-induced pulmonary inflammation by the regulated degradation of both IkappaB-alpha and IkappaB-beta
temporal control of NF-kappaB activation by the coordinated degradation and synthesis of IkappaB proteins
beta-TrCP1 contributes to, but is not absolutely required for, the degradation of I kappa B and beta-catenin
Direct administration of dominant negative I-kappa B or tyrosine 42-mutated I-kappa B proteins before induction of inflammatory arthritis attenuates in vivo activation of NF-kappa B and blocks joint swelling, osteoclast recruitment, and osteolysis.
IkappaBalpha and IkappaBbeta play unique injury context-specific roles in activating NF-kappaB-mediated proinflammatory responses
activation required for HSV-1 efficient replication
Results suggest that tight control of IkappaBbeta protein by p65 is necessary for the maintenance of cellular homeostasis.
In vivo degradation rate constants were measured for NF-kappaB-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
These results show that mitochondrial stress signaling uses an IkappaBbeta-initiated NFkappaB pathway that is distinct from the other known NFkappaB pathways.
The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib.
data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB.
our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway.
NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing.
IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis
Data show that increased nuclear factor-kappaB (NF-kB) activity in the amnion during labor is associated with an increase in the expression of NF-kBp65 and of the NF-kB binding proteins IkBa, IkBb-1 and IkBb-2.
VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif.
data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta
None of the NFKBIB SNPs are associated with pneumococcal susceptibility.
NF-kappaB, IkappaB-alpha, IkappaB-beta mRNA decreased significantly after weight loss.
increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization.
NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles.
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
, NF-kappa-B inhibitor beta
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
, TR-interacting protein 9
, thyroid receptor-interacting protein 9