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anti-Human PRKACA Antibodies:
anti-Rat (Rattus) PRKACA Antibodies:
anti-Mouse (Murine) PRKACA Antibodies:
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Human Polyclonal PRKACA Primary Antibody for ICC, IF - ABIN408069 : Enns, Morton, Mangalindan, McKnight, Schwartz, Kaeberlein, Kennedy, Rabinovitch, Ladiges: Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. in The journals of gerontology. Series A, Biological sciences and medical sciences 2009 (PubMed)
Human Polyclonal PRKACA Primary Antibody for ELISA, WB - ABIN562366 : Adachi, Kano, Saido, Murata: Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. in Genes to cells : devoted to molecular & cellular mechanisms 2009 (PubMed)
Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 (show ARPP19 Antibodies) by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A (show PPP2R4 Antibodies) disinhibition.
CTR (show CALCR Antibodies) activates AKAP2 (show AKAP2 Antibodies)-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 (show TJP1 Antibodies) and claudin 3 (show CLDN3 Antibodies).
These results indicate that Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC (show FAM126A Antibodies)) is similar to pure FL-HCC (show FAM126A Antibodies) at the genomic level and the DNAJB1 (show DNAJB1 Antibodies):PRKACA fusion can be used as a diagnostic tool for both pure and mFL-HCC (show FAM126A Antibodies)
PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are affected by a more severe phenotype and are identified at a younger age.
Somatic mutations in PRKACA, coding for the catalytic alpha subunit (show POLG Antibodies) of protein kinase A (PKA), have been recently identified as the most frequent genetic alteration in cortisol-secreting adrenocortical adenomas, which are responsible for adrenal Cushing's syndrome.
HIF1a (show HIF1A Antibodies) transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
cigarette smoke extracts activate the PKA, CREB (show CREB1 Antibodies), and IL-13Ralpha2 axis in lung endothelial cells.
Data indicate a subpopulation of the CaV1.2 (show CACNA1C Antibodies) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
we propose that the PKA-Smurf1 (show SMURF1 Antibodies)-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
The mutated PRKACA proteins lost their ability to bind to PRKAR1A (show PRKAR1A Antibodies), and thereby lead to constitutive activation of the PKA pathway. Together with previous reports of PRKAR1A (show PRKAR1A Antibodies) mutations in syndromic cardiac myxoma, our study demonstrates the importance of the PKA pathway in the tumourigenesis of cardiac myxoma.
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
structural basis of selectivity for protein kinase A in complex with Rho-kinase (show ROCK1 Antibodies) inhibitors by x-ray crystallography
Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.
ceramide as a potent physiological modulator of the Na(+)-ATPase (show DNAH8 Antibodies), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (show PRKCZ Antibodies)
we demonstrate that PKA, PKC (show FYN Antibodies) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (show GSK3a Antibodies) phosphorylation which subsequently controls cell motility.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB (show CREB1 Antibodies) signaling.
Generation of the Dnajb1 (show DNAJB1 Antibodies)-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (show SCP2 Antibodies)), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C Antibodies) and enhancement of its activity by the beta2-adrenergic receptor (show ADRB2 Antibodies) (beta2AR (show ADRB2 Antibodies))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (show NRG1 Antibodies) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
study identifies a new role of Dual-AKAP1 (show AKAP1 Antibodies) in regulating mitochondrial trafficking through Miro-2 (show RHOT2 Antibodies), and supports a model in which PINK1 (show PINK1 Antibodies) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (show SHH Antibodies) signaling through regulation of GLI3 (show GLI3 Antibodies) processing.
this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (show CSF1R Antibodies) DNA methylation (show HELLS Antibodies) resulting in macrophage maturation
support hypothesis that PRKACA activation is responsible for downstream protein tyrosine phosphorylation events in stallion sperm
Thus Ca(2 (show CA2 Antibodies)+)-cAMP/PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous action potential firing rate.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
PKA C-alpha , cAMP-dependent protein kinase catalytic subunit alpha , protein kinase A catalytic subunit , cAMP-dependent protein kinase catalytic subunit C alpha , protein kinase A , protein kinase, cAMP-dependent, catalytic, alpha , C-alpha subunit , sperm cAMP-dependent protein kinase catalytic subunit , protein kinase A alpha , prkaca , PKA catalytic subunit alpha
