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Full name:: Sequestosome 1 Proteins (SQSTM1)

On www.antibodies-online.com are 11 Sequestosome 1 (SQSTM1) Proteins from 0 different suppliers available. A total of 414 SQSTM1 products are currently listed.

Synonyms:: A170, MGC79491, OSF-6, Osi, OSIL, p60, p62, p62B, PDB3, sb:cb621, sqstm1, STAP, zgc:85784, ZIP, ZIP3

list all proteins	Gene Name	GeneID	UniProt
Human SQSTM1	SQSTM1	8878	Q13501
Mouse SQSTM1	SQSTM1	18412	Q64337
Rat SQSTM1	SQSTM1	113894	O08623
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Human Sequestosome 1 (SQSTM1) interaction partners

The results suggest that p62 may be an effective predictor of prognosis and a potential target for therapy in osteosarcoma.
The model reveals a compensatory autophagic pathway, mediated by a SQSTM1/p62-dependent clearance of accumulated polyubiquitinated proteins. In addition to mediating the sequestration of ubiquitinated cargos into phagophores, the precursors to autophagosomes, SQSTM1 is also important for polyubiquitinated aggregate formation upon proteasomal inhibition.
ESI (show PI3 Proteins) induces protective autophagy of lung cancer cells through Nrf2 (show GABPA Proteins)-p62 (show GTF2H1 Proteins)-keap1 (show KEAP1 Proteins) feedback loop
IFN-gamma induces activated but insufficient autophagy and thus contributes to a degree to p62-dependent apoptosis of nasal epithelial cells in chronic rhinosinusitis with nasal polyps.
The underling mechanism of autophagy/p62 (show GTF2H1 Proteins)/Nrf2 (show GABPA Proteins) pathway discovered may provide a new direction for drug development.
Study show the proteasome autophagy mechanism is mediated by the p62/SQSTM1 adapter and requires its ubiquitin-associated domain. Independently, p62 (show GTF2H1 Proteins) serves also as a shuttling protein for ubiquitinated substrates, using its PB1 (show SMR3A Proteins) domain. This places p62 (show GTF2H1 Proteins) in a pivotal position where under certain conditions it binds to the proteasome as a protease, whereas in other conditions it recognizes the proteasome as a prey.
The study describes a previously uncharacterized cellular response induced by heme: the formation of p62/SQSTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-like induced structures (ALIS). This action is part of a response driven by the transcription factor NRF2 (show GABPA Proteins) to the excessive generation of reactive oxygen species induced by heme.
The data identify an intricate mechanism of hepatitis C virus-dependent inhibition of Nrf2 (show GABPA Proteins)/ antioxidant response elements-mediated gene expression which counteracts serine 349-phosphorylated p62 (show GTF2H1 Proteins)-induced activation of Nrf2 (show GABPA Proteins).
Results identified SQSTM1, a regulator of apoptosis and autophagy, to be hyper-phosphorylated and associated with development of cisplatin resistance in high-grade serous ovarian cancer.
p62 immunoreactivity was detected in 11% of colorectal adenoma and 31% of the adenocarcinoma cases, and almost negligible in the normal epithelium. p62 promotes cell proliferation in colorectal carcinoma cells, was significantly associated with synchronous liver metastasis in the colorectal carcinoma cases, and was an independent adverse prognostic factor for overall survival in the colorectal cancer patients.

Mouse (Murine) Sequestosome 1 (SQSTM1) interaction partners

p62 serves to prevent endoplasmic reticulum stress in mouse hypothalamus by maintaining protein folding capacity
The p62 (show GTF2H1 Proteins)-keap1 (show KEAP1 Proteins)-Nrf2 (show NFE2L2 Proteins) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (show MAP1LC3A Proteins) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 (show ENC1 Proteins) interacts with the phosphorylated p62 (show GTF2H1 Proteins) to impair autophagic degradation of mutant huntingtin (show HTT Proteins) protein aggregates.
this study proved that SYVN1 (show SYVN1 Proteins) enhances SERPINA1 (show SERPINA1 Proteins)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (show SERPINA1 Proteins)(E342K)/ATZ cytotoxicity.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 (show MAP1LC3B Proteins) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 Proteins) and down-regulates Lc3 (show MAP1LC3A Proteins)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 (show MAP1LC3B Proteins) = microtubule-associated protein (show SPAG5 Proteins) 1-light chain 3)
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (show PTH Proteins) promotes selective autophagy via induction of DAPK2 (show DAPK2 Proteins)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.

Zebrafish Sequestosome 1 (SQSTM1) interaction partners

Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.

SQSTM1 Protein Profile

Protein Summary

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SQSTM1

sequestosome 1 (SQSTM1)
sequestosome 1 (sqstm1)
sequestosome 1 (Sqstm1)
sequestosome 1 L homeolog (sqstm1.L)

A170 protein
MGC79491 protein
OSF-6 protein
Osi protein
OSIL protein
p60 protein
p62 protein
p62B protein
PDB3 protein
sb:cb621 protein
sqstm1 protein
STAP protein
zgc:85784 protein
ZIP protein
ZIP3 protein

Protein level used designations for Sequestosome 1 Proteins (SQSTM1)

sequestosome 1 , sequestosome-1 , sequestosome-1-like , sqstm1 protein , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , ubiquitin-binding protein p62 , STONE14 , oxidative stress induced , PKC-zeta-interacting protein , protein kinase C-zeta-interacting protein

GENE ID	SPECIES
462333	Pan troglodytes
705481	Macaca mulatta
770805	Gallus gallus
100135450	Ovis aries
100342157	Oryctolagus cuniculus
100385650	Callithrix jacchus
493277	Xenopus (Silurana) tropicalis
100067231	Equus caballus
8878	Homo sapiens
18412	Mus musculus
113894	Rattus norvegicus
406452	Danio rerio
379610	Xenopus laevis
338045	Bos taurus
481459	Canis lupus familiaris
100172461	Pongo abelii

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