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The data identify an intricate mechanism of hepatitis C virus-dependent inhibition of Nrf2 (show GABPA Proteins)/ antioxidant response elements-mediated gene expression which counteracts serine 349-phosphorylated p62 (show GTF2H1 Proteins)-induced activation of Nrf2 (show GABPA Proteins).
Results identified SQSTM1, a regulator of apoptosis and autophagy, to be hyper-phosphorylated and associated with development of cisplatin resistance in high-grade serous ovarian cancer.
p62 immunoreactivity was detected in 11% of colorectal adenoma and 31% of the adenocarcinoma cases, and almost negligible in the normal epithelium. p62 promotes cell proliferation in colorectal carcinoma cells, was significantly associated with synchronous liver metastasis in the colorectal carcinoma cases, and was an independent adverse prognostic factor for overall survival in the colorectal cancer patients.
NEDD4 (show NEDD4 Proteins) is an autophagic E3 ubiquitin ligase (show MUL1 Proteins) that ubiquitylates SQSTM1, facilitating SQSTM1-mediated inclusion body autophagy.
SQSTM1/p62 senses the saturation of reactive oxygen species (ROS (show ROS1 Proteins))-buffering systems, and that this redox-sensitivity is important to increase autophagy, and thus ensure the survival of cells under oxidative stress conditions.
This study is the first to show a cytoplasmic function of claudin 1 (show CLDN7 Proteins) as an autophagy regulator and provides the evidence that claudin 1 (show CLDN7 Proteins)-mediated autophagy regulation is an integral part of the mechanism by which claudin 1 (show CLDN7 Proteins) regulates cancer progression.
The autophagy induced by 2-PCPA requires LC3 (show MAP1LC3A Proteins)-II processing machinery..2-PCPA treatment induces the change of global gene expression program, including a series of autophagy-related genes, such as SQSTM1/p62. Taken together, our data indicate that KDM1A/LSD1 (show KDM1A Proteins) inhibitors induce autophagy through affecting the expression of autophagy-related genes and in a BECN1 (show BECN1 Proteins)-independent manner
The results of this study reflect that Frontotemporal Dementia /SQSTM1 carriers show a right atrophy pattern in prefrontal-orbital-insular regions with relative preservation of the temporal lobes different from that observed in Sporadic Frontotemporal Dementia.
the L341V mutation limits the critical step of SQSTM1 recruitment to the phagophore
Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug.
p62 serves to prevent endoplasmic reticulum stress in mouse hypothalamus by maintaining protein folding capacity
The p62 (show GTF2H1 Proteins)-keap1 (show KEAP1 Proteins)-Nrf2 (show NFE2L2 Proteins) antioxidant pathway was primarily activated in the early stage of APAP hepatotoxicity.
analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 (show MAP1LC3A Proteins) using a combination of fluorescence microscopy-based biophysical approaches in living cells
ENC1 (show ENC1 Proteins) interacts with the phosphorylated p62 (show GTF2H1 Proteins) to impair autophagic degradation of mutant huntingtin (show HTT Proteins) protein aggregates.
this study proved that SYVN1 (show SYVN1 Proteins) enhances SERPINA1 (show SERPINA1 Proteins)(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1 (show SERPINA1 Proteins)(E342K)/ATZ cytotoxicity.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 and Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 (show MAP1LC3B Proteins) in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (show GTF2H1 Proteins) and down-regulates Lc3 (show MAP1LC3A Proteins)-II in neonatal liver. (p62/Sqstm1 = sequestosome 1; Lc3 (show MAP1LC3A Proteins)-II/Map1lc3 (show MAP1LC3B Proteins) = microtubule-associated protein (show SPAG5 Proteins) 1-light chain 3)
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
SQSTM1 dynamically associates with DNA damage foci (DDF) and regulates DNA repair.
Thyroid hormone (show PTH Proteins) promotes selective autophagy via induction of DAPK2 (show DAPK2 Proteins)-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
, sqstm1 protein
, EBI3-associated protein of 60 kDa
, EBI3-associated protein p60
, oxidative stress induced like
, phosphotyrosine independent ligand for the Lck SH2 domain p62
, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
, ubiquitin-binding protein p62
, oxidative stress induced
, PKC-zeta-interacting protein
, protein kinase C-zeta-interacting protein