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Genotype rs767455 was associated with the susceptibility of ankylosing spondylitis(AS), G allele of rs767455 exhibited an association with the risk of developing AS. Only rs1061622 was significantly associated with long-term efficacy of etanercept. The results suggest that TNFRSF1A (show TNFRSF1A Proteins) and TNFRSF1B polymorphisms were associated with susceptibility, severity, and the long-term therapeutic efficacy of etanercept of AS patients.
Data suggest that maternal glycemic response during pregnancy is associated with lower DNA methylation (show HELLS Proteins) of 4 CpG sites within PDE4B (show PDE4B Proteins) gene in placenta (collected after normal-weight term birth); 3 additional CpG sites are differentially methylated relative to maternal glucose response within TNFRSF1B, LDLR (show LDLR Proteins), and BLM (show BLM Proteins) genes. (PDE4B (show PDE4B Proteins) = phosphodiesterase-4B; LDLR (show LDLR Proteins) = low density lipoprotein receptor (show LDLR Proteins); BLM (show BLM Proteins) = Bloom syndrome protein (show BLM Proteins))
serum level did not change after tonsillectomy alone but decreased significantly after steroid pulse therapy in patients with IgA nephropathy
Elevated serum TNFR2 may be a possible marker of COPD (show ARCN1 Proteins) in asymptomatic smokers and ex-smokers.
TNFR2 promoted Adriamycin resistance in breast cancer cells by regulating the DNA damage repair.
Serum TNFR2 is a biomarker for patients with chronic kidney disease.
Data indicate activators of tumor necrosis factor receptor 2 (TNFR2) and a potential role for this target in immunotherapy.
In this study, we identified a novel association between ANCA levels, TNFRSF1B genotype and decreased circulating TNFR2 levels, which may be reflective of the underlying biological mechanisms that determine clinical expression and/or response to certain therapies.
In Han Chinese population of Hunan province, TNFRSF1B+676 gene polymorphisms are not associated with the genetic risk of rheumatoid arthritis
Coadministration of either ATROSAB or EHD2 (show EHD2 Proteins)-scTNFR2 into the magnocellular nucleus basalis significantly protected cholinergic neurons and their cortical projections against cell death, and reverted the neurodegeneration-associated memory impairment in a passive avoidance paradigm. Simultaneous blocking of TNFR1 (show TNFRSF1A Proteins) and TNFR2 signaling, however, abrogated the therapeutic effect
These results show an unclear effect of considered T>C polymorphism on TNF-RII gene expression in bovine leukocytes and they suggest the involvement of BLV in modifying the TNF-RII expression in BLV-infected cows.
These results suggest that the endometrium might lower the TNF (show TNF Proteins) concentration in the blastocyst by (1) regulating TNF (show TNF Proteins) secretion into the uterine fluid and (2) inducing decreased TNF (show TNF Proteins) and TNFR2 mRNA transcription in the embryo.
These results suggest that TNF-alpha (show TNF Proteins) sources include immune cells, as well as large and small luteal cells, and that TNF-RI (show TNFRSF1A Proteins) and TNF-RII are present in the luteal cells of the bovine corpus luteum.
The expression and cellular localization of tumor necrosis factor-alpha (TNF (show TNF Proteins)) and its receptors (TNFRI (show TNFRSF1A Proteins) and TNFRII) mRNAs and proteins, were determined.[TNFRII]
Retinal ischemia results in increased expression of TNF-alpha (show TNF Proteins) and its receptors (TNF-R1 (show TNFRSF1A Proteins) and TNF-R2).
Porcine TNFR2 (1,125 bp, 375 amino acid residues), which contains specific amino acid region of transmembrane, indicated high identities with human and murine TNFR2
TNFR2 sensitizes macrophages for endogenous TNF (show TNF Proteins)-induced TNFR1 (show TNFRSF1A Proteins)-mediated necroptosis
study reports an important role for TNFR2 on low-affinity-primed secondary effector CD8 (show CD8A Proteins)+ T cells; results demonstrate the importance of TNF (show TNF Proteins) signaling in low-affinity, cross-reactive CD8 (show CD8A Proteins)+ T cell responses during heterologous immunity
TNF (show TNF Proteins) plays an inhibitory role in modulating myocardial SDF-1 (show CXCL12 Proteins) production and blockade of TNF (show TNF Proteins) signaling by ablation of TNFR1 (show TNFRSF1A Proteins) and TNFR2 genes increased SDF-1 (show CXCL12 Proteins) expression in the heart. These data expand on TNF (show TNF Proteins) signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 (show CXCL12 Proteins) and TNFR (show TNFRSF1A Proteins)-derived actions in hopes of advancing ischemic heart injury treatments.
Results suggest that elevated TNF (show TNF Proteins) in the heart, via TNFR1 (show TNFRSF1A Proteins) and TNFR2, restrains cardiomyocyte differentiation of resident cardiac stem cells and may enhance adrenergic activation, both effects that would reduce the effectiveness of endogenous cardiac repair and the response to exogenous stem cell therapy, while promoting adverse cardiac remodeling.
Report chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced by oral dibutyltin administration in TNFR1 (show TNFRSF1A Proteins)/R2 deficient mice.
These findings implicate TNF (show TNF Proteins)-receptor signaling cascades in the regulation of homeostatic plasticity of denervated networks and suggest an important role for TNFalpha (show TNF Proteins)-signaling in the course of neurological diseases accompanied by deafferentation.
TNF (show TNF Proteins) receptor 1 (TnfR1 (show TNFRSF1A Proteins)) signaling is believed to be a major mediator of the cytotoxicity of Tnf-a (show TNF Proteins) through activation of caspases.
our findings implicate TNFR2 in supporting myeloid-derived suppressor cells -mediated immune suppression and metastasis in the liver
TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice.
TNFR2 protects mice from colitis by inhibiting the expansion of colonic CD8 (show CD8A Proteins)(+) T cells.
Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8 (show CASP8 Proteins), caspase-2 (show CASP2 Proteins) and P53 (show TP53 Proteins)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Proteins).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
, p75 TNF receptor
, p80 TNF-alpha receptor
, soluble TNFR1B variant 1
, tumor necrosis factor beta receptor
, tumor necrosis factor binding protein 2
, tumor necrosis factor receptor 2
, tumor necrosis factor receptor superfamily member 1B
, tumor necrosis factor receptor type II
, tumor necrosis factor receptor-II
, tumor necrosis factor receptor superfamily, member 1B
, TNF receptor beta chain
, p75 TNFR