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Human TNFSF13B ELISA Kit for Sandwich ELISA - ABIN365023
Cheng, Yan, Zhao, Huang, Lian, Wei: The effect of BLyS on the activity of peripheral B lymphocytes mediated by BLyS receptors in patients with systemic lupus erythematosus. in Scandinavian journal of clinical and laboratory investigation 2013
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Rat (Rattus) TNFSF13B ELISA Kit for Sandwich ELISA - ABIN432279
Reese, Wilson, Huang, Redfield, Zhong, Djamali: Calcineurin Inhibitor Minimization With Ixazomib, an Investigational Proteasome Inhibitor, for the Prevention of Antibody Mediated Rejection in a Preclinical Model. in Transplantation 2015
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Mouse (Murine) TNFSF13B ELISA Kit for Sandwich ELISA - ABIN367653
Zhang, Li, Song, Liu, Wang, Chang, Wu, Chen, Zhao, Zhang, Zhou, Wei: Comparative efficacy of TACI-Ig with TNF-alpha inhibitor and methotrexate in DBA/1 mice with collagen-induced arthritis. in European journal of pharmacology 2013
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Human TNFSF13B ELISA Kit for Sandwich ELISA - ABIN921083
Schiemann, Gommerman, Vora, Cachero, Shulga-Morskaya, Dobles, Frew, Scott: An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. in Science (New York, N.Y.) 2001
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Human TNFSF13B ELISA Kit for Sandwich ELISA - ABIN417213
Augusto, Bonfa, Pereira, Bueno, Leon, Viana, Pasoto: Metabolic syndrome in Sjögren's syndrome patients: a relevant concern for clinical monitoring. in Clinical rheumatology 2016
Equine adipose-derived stem cell (ASC (show PYCARD ELISA Kits)) expresses BAFF (TNFSF13B) and its receptors, which may be associated with the differentiation process of ASC (show PYCARD ELISA Kits) towards adipocyte.
results showed that serum BAFF in nasal type, extranodal NK/T cell lymphoma patients was significantly higher than that in control group and negatively correlated with patients' survival.
BAFF has a role in inducing IL35 (show EBI3 ELISA Kits) production by regulatory B cells in lupus
Inhibition of ADAM10 (show ADAM10 ELISA Kits) augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 (show ADAM17 ELISA Kits) increases BAFFR (show TNFRSF13C ELISA Kits) expression levels
Data presented show that B-cell activating factor (BAFF) plays a central role in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies and suggest a therapeutic potential for BAFF blockade in limiting autoimmune processes associated with smoking.
Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand (show CAMLG ELISA Kits) interactor (TACI (show TNFRSF13B ELISA Kits)) and B cell maturation antigen (BCMA (show TNFRSF17 ELISA Kits)) do not change
The BAFF promoter increased in response to TNF-alpha (show TNF ELISA Kits) treatment or overexpression of HIF-1alpha (show HIF1A ELISA Kits). However, TNF-alpha (show TNF ELISA Kits)-induced BAFF expression and promoter activity decreased after treatment with the ERK (show EPHB2 ELISA Kits) inhibitor PD98059.
This study indicates that orbital fibroblasts from Graves' orbitopathy can express BAFF and mediate the intraorbital survival of B cells via BAFF mechanism.
Inhibition of B cell plasmablast differentiation by reduction of Aiolos (show IKZF3 ELISA Kits) and Ikaros (show IKZF1 ELISA Kits) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos (show IKZF3 ELISA Kits) may prime CD27 (show CD27 ELISA Kits)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.
BCMA (show TNFRSF17 ELISA Kits) has other contributors for ligands binding except DxL motif. The affinity of BCMA (show TNFRSF17 ELISA Kits) for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
study demonstrated a high prevalence of endogenous antibodies to BAFF in a multi-ethnic Asian systemic lupus erythematosus (SLE) cohort; while levels of serum BAFF correlated positively with disease activity, levels of anti-BAFF antibody were correlated negatively with levels of its target cytokine, anti-dsDNA antibody and clinical disease activity
This study suggests that BAFF selects IL-10 (show IL10 ELISA Kits)(-)B cells over IL-10 (show IL10 ELISA Kits)(+) regulatory B cells via BAFF receptors in inflammatory responses
BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli.
this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI (show TNFRSF13B ELISA Kits)-dependent B cell activation (show BLNK ELISA Kits)
B cell-activating factor (BAFF) upregulates CD28 (show CD28 ELISA Kits)/B7 and CD40 (show CD40 ELISA Kits)/CD154 (show CD40LG ELISA Kits) expression, and promotes the interactions between T and B cells in a BAFF receptor (show TNFRSF13C ELISA Kits)-dependent manner.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI (show TNFRSF13B ELISA Kits)-dependent activation of transitional B cells
neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production.
The enhanced thermogenic program was confirmed by higher protein levels of UCP1 (show UCP1 ELISA Kits) and irisin (show FNDC5 ELISA Kits) in female BAFF-/- than in WT mice.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF (show TNF ELISA Kits)) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Increased B-cell activating factor (BAFF) induced B cell differentiation into germinal center (GC) B (show NPR2 ELISA Kits) cells within the autoimmune target tissue.
study reports the molecular cloning, expression and bioactivity of the porcine homologue of human BAFF
This study demonstrated expression of BAFF on cultured monocyte-derived dendritic cells, which was further enhanced by interferon-alpha (show IFNA ELISA Kits) or interferon-gamma (show IFNG ELISA Kits) treatment.
Although BAFF expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (show GUSB ELISA Kits)-associated lymphoid tissue.
BAFF and its receptors during B-cell activation (show BLNK ELISA Kits) and autoantibody production in rabbits derived from selective breeding to develop a reproducible rabbit model of Systemic Lupus Erythematosus, were investigated.
Cloning and expression analysis of B-cell activating factor (BAFF) provide the basis for investigation of its role in regulating rabbit B-lymphocyte (show AKAP17A ELISA Kits) development and immune responses.
BAFF was detected in developing appendix of young rabbits by immunohistochemical staining suggesting that BAFF plays a role during the period following birth when rabbit B-cell development is occurring.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
tumor necrosis factor ligand superfamily member 13B
, tumor necrosis factor (ligand) superfamily, member 13b
, B-cell activating factor
, B-lymphocyte stimulator
, TNF- and APOL-related leukocyte expressed ligand 1
, ApoL related ligand TALL-1
, B-cell-activating factor
, Delta4 BAFF
, TNF and ApoL-related leukocyte expressed ligand 1
, TNF homolog that activates apoptosis
, delta BAFF
, dendritic cell-derived TNF-like molecule
, tumor necrosis factor (ligand) superfamily, member 20
, tumor necrosis factor-like protein ZTNF4
, b cell-activating factor
, tumor necrosis factor superfamily member 13b