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A dramatic decline in ephrinB2 (show EFNB2 Proteins) protein levels on the absence of flotillin-1 (show FLOT1 Proteins) expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease ADAM10.
significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs
Data show that ADAM10 and APLP2 (show APLP2 Proteins) are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins.
Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain.
N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity.
SNHG20 could function as an oncogenic long non-coding RNA by regulating miR (show MLXIP Proteins)-140-5p-ADAM10 axis and MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling pathway in cervical cancer.
restoration of ADAM10 expression partially reversed the effects of miR152 on cell proliferation and apoptosis in rheumatoid arthritisfibroblastlike synoviocytes.
Mechanisms underlying ADAM10 downregulation by miR (show MLXIP Proteins)-140-5p and suggests that dysfunctional regulation of ADAM10 expression is exacerbated by AD-related neurotoxic effects.
elevated expression of ADAM10 was associated with the pathogenesis and development of immune thrombocytopenia
Report overexpression of ADAM10 in oral squamous cell carcinomas, especially in OSCC with metastasis.
High ADAM10 expression is associated with meningococcal purpura fulminans.
The findings of the present study suggested that miR320a may function as a tumor suppressor in GC progression and potential therapeutic strategies for GC may be based on the miR320a/ADAM10 axis.
Insulin-like growth factor-1 (show IGF1 Proteins) activates different catalytic subunits p110 (show CUX1 Proteins) of PI3K (show PIK3CA Proteins) in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17 (show ADAM17 Proteins).
mechanistic experiments revealed that ADAM10-RNAi resulted in an increase in E-cadherin (show CDH1 Proteins) and a decrease in N-cadherin (show CDH2 Proteins) and vimentin (show VIM Proteins) expression. Our study implies that high expression of ADAM10 promotes the proliferation and migration of hypopharyngeal squamous cell carcinoma (HSCC). These findings may help to provide a method for treatment of HSCC
Notch (show NOTCH1 Proteins) is ligand activated and undergoes DTX4 (show DTX4 Proteins)-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing
Data show that tetraspanin15 (Tspan15 (show TSPAN15 Proteins)) is abundantly expressed in brain, where it specifically interacts with endogenous a disintegrin and metalloproteinase 10 (ADAM10).
ADAM10(DC)(-/-) mice are resistant to IgE-mediated anaphylaxis.
In the present study, we report that Nrxn3beta is processed by the metalloproteases ADAM10, ADAM17 (show ADAM17 Proteins), and by the intramembrane-cleaving protease gamma-secretase, producing secreted neurexin3beta (sNrxn3beta) and a single intracellular domain (Nrxn3beta-ICD). Thea (show ACOT11 Proteins) authors show that sNrxn3beta produced by the cells of the dentate gyrus increases the spine density of newborn neurons.
the synaptic localization of APP (show APP Proteins), ADAM10, and BACE1 (show BACE Proteins) in the mouse cerebral cortex, was examined.
Pharmacological inhibition of ADAM10 reduces sEphrin-B2 levels in bronchoalveolar lavage and prevents lung fibrosis in mice. Consistent with the mouse data, ADAM10-sEphrin-B2 signaling is upregulated in fibroblasts from human subjects with idiopathic pulmonary fibrosis.
Xenoestrogens biphenol-A and nonylphenol stimulate the release of EGFR (show EGFR Proteins)-ligands by differentially activating ADAM17 (show ADAM17 Proteins) or ADAM10.
study confirms the importance of ICOSL (show ICOSLG Proteins) shedding in ICOS (show ICOS Proteins)/ICOSL (show ICOSLG Proteins) function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL (show ICOSLG Proteins) levels
Tspan3 (show TSPAN3 Proteins) is a central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein (show APP Proteins).
these results show that ADAM10-Notch (show NOTCH1 Proteins) signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.
Findings provide evidence that ADAM10, and not ADAM17 (show ADAM17 Proteins), is indispensable for proper retinal development as a regulator of NOTCH (show NOTCH1 Proteins) signaling.
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
a disintegrin and metalloproteinase domain 10
, disintegrin and metalloproteinase domain-containing protein 10
, ADAM metallopeptidase domain 10
, ADAM10 metallopeptidase
, a disintegrin and metalloprotease domain 10a
, ADAM 10
, kuzbanian protein homolog
, a disintegrin and metalloprotease domain 10
, mammalian disintegrin-metalloprotease
, myelin-associated metalloproteinase
, a disintegrin and metalloprotease domain (ADAM) 10
, a disintegrin and metallopeptidase domain 10
, disintegrin and metalloproteinase domain-containing protein 10-like
, ADAM metallopeptidase domain 10b
, a disintegrin and metalloprotease domain 10b